Gene Review:
CYP4B1 - cytochrome P450, family 4, subfamily B,...
Homo sapiens
Synonyms:
CYPIVB1, Cytochrome P450 4B1, Cytochrome P450-HP, P-450HP
- Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. Lo-Guidice, J.M., Allorge, D., Cauffiez, C., Chevalier, D., Lafitte, J.J., Lhermitte, M., Broly, F. Pharmacogenetics (2002)
- New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. Rainov, N.G., Dobberstein, K.U., Sena-Esteves, M., Herrlinger, U., Kramm, C.M., Philpot, R.M., Hilton, J., Chiocca, E.A., Breakefield, X.O. Hum. Gene Ther. (1998)
- Sites of covalent attachment of CYP4 enzymes to heme: evidence for microheterogeneity of P450 heme orientation. Baer, B.R., Schuman, J.T., Campbell, A.P., Cheesman, M.J., Nakano, M., Moguilevsky, N., Kunze, K.L., Rettie, A.E. Biochemistry (2005)
- Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. Czerwinski, M., McLemore, T.L., Gelboin, H.V., Gonzalez, F.J. Cancer Res. (1994)
- Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism. Czerwinski, M., McLemore, T.L., Philpot, R.M., Nhamburo, P.T., Korzekwa, K., Gelboin, H.V., Gonzalez, F.J. Cancer Res. (1991)
- Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity. Hakkola, J., Pelkonen, O., Pasanen, M., Raunio, H. Crit. Rev. Toxicol. (1998)
- Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma. Mohr, L., Rainov, N.G., Mohr, U.G., Wands, J.R. Cancer Gene Ther. (2000)
- Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells. Liu, S., Stromberg, A., Tai, H.H., Moscow, J.A. Mol. Cancer Res. (2004)
- Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors. Chen, L., Hardwick, J.P. Arch. Biochem. Biophys. (1993)
- Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. Furukawa, M., Nishimura, M., Ogino, D., Chiba, R., Ikai, I., Ueda, N., Naito, S., Kuribayashi, S., Moustafa, M.A., Uchida, T., Sawada, H., Kamataki, T., Funae, Y., Fukumoto, M. Cancer Sci. (2004)
- Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate. Zheng, Y.M., Baer, B.R., Kneller, M.B., Henne, K.R., Kunze, K.L., Rettie, A.E. Biochemistry (2003)
- CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism. Baer, B.R., Rettie, A.E. Drug Metab. Rev. (2006)
- The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. Windmill, K.F., McKinnon, R.A., Zhu, X., Gaedigk, A., Grant, D.M., McManus, M.E. Mutat. Res. (1997)
- Expression of cytochrome P450 enzymes CYP1A1, CYP1B1, CYP2E1 and CYP4B1 in cultured transitional cells from specimens of the human urinary tract and from urinary sediments. Roos, P.H., Belik, R., Föllmann, W., Degen, G.H., Knopf, H.J., Bolt, H.M., Golka, K. Arch. Toxicol. (2006)
- Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues. McKinnon, R.A., Burgess, W.M., Gonzalez, F.J., Gasser, R., McManus, M.E. Pharmacogenetics (1994)
- CYP4B1 is a possible risk factor for bladder cancer in humans. Imaoka, S., Yoneda, Y., Sugimoto, T., Hiroi, T., Yamamoto, K., Nakatani, T., Funae, Y. Biochem. Biophys. Res. Commun. (2000)
- Covalent linkage of prosthetic heme to CYP4 family P450 enzymes. Henne, K.R., Kunze, K.L., Zheng, Y.M., Christmas, P., Soberman, R.J., Rettie, A.E. Biochemistry (2001)
- Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate. Baer, B.R., Rettie, A.E., Henne, K.R. Chem. Res. Toxicol. (2005)
- Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1. Zheng, Y.M., Fisher, M.B., Yokotani, N., Fujii-Kuriyama, Y., Rettie, A.E. Biochemistry (1998)
- A transgenic mouse expressing human CYP4B1 in the liver. Imaoka, S., Hayashi, K., Hiroi, T., Yabusaki, Y., Kamataki, T., Funae, Y. Biochem. Biophys. Res. Commun. (2001)
- Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR. Finnström, N., Bjelfman, C., Söderström, T.G., Smith, G., Egevad, L., Norlén, B.J., Wolf, C.R., Rane, A. Eur. J. Clin. Invest. (2001)
- Molecular mechanisms regulating human CYP4B1 lung-selective expression. Poch, M.T., Cutler, N.S., Yost, G.S., Hines, R.N. Drug Metab. Dispos. (2005)