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Gene Review

MtnA  -  Metallothionein A

Drosophila melanogaster

Synonyms: BcDNA:GH18460, CG9470, Dmel\CG9470, DrosMtn, MT-1, ...
 
 
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Disease relevance of MtnA

 

High impact information on MtnA

 

Biological context of MtnA

 

Anatomical context of MtnA

 

Associations of MtnA with chemical compounds

  • Such a metal preference is also observed at the protein level as the stoichiometric, spectrometric and spectroscopic features of the copper and cadmium complexes with MtnA and MtnB correlate well with a greater stability of copper-MtnA and cadmium-MtnB [1].
  • Mercury, silver, and zinc induced metallothionein to a lesser extent [14].
  • Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster [7].
  • Poly(A) signals of both mammalian (SV40) and Drosophila (Mtn) origin efficiently directed stable RNA synthesis in S2 cells, and, as in mammalian cells, the SV40 late poly(A) signal was more efficient than the SV40 early poly(A) signal [15].
 

Regulatory relationships of MtnA

  • We have produced polyclonal antibodies to a recombinant dpp protein made in bacteria and used a metallothionein promoter to express a dpp cDNA in Drosophila S2 cells [16].
  • A cloned Drosophila muscarinic acetylcholine receptor (mAChR) has been stably expressed in a Drosophila cell line (S2) under the control of an inducible Drosophila metallothionein promoter [17].
 

Other interactions of MtnA

 

Analytical, diagnostic and therapeutic context of MtnA

References

  1. The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification. Egli, D., Domènech, J., Selvaraj, A., Balamurugan, K., Hua, H., Capdevila, M., Georgiev, O., Schaffner, W., Atrian, S. Genes Cells (2006) [Pubmed]
  2. Copper treatment increases recombinant baculovirus production and polyhedrin and p10 expression. Lanier, L.M., Storm, K., Shafaie, A., Volkman, L.E. BioTechniques (1997) [Pubmed]
  3. A Drosophila metallothionein promoter is inducible in mosquito cells. Kovach, M.J., Carlson, J.O., Beaty, B.J. Insect Mol. Biol. (1992) [Pubmed]
  4. Purification and characterization of hepatitis B virus surface antigen particles produced in Drosophila Schneider-2 cells. Deml, L., Schirmbeck, R., Reimann, J., Wolf, H., Wagner, R. J. Virol. Methods (1999) [Pubmed]
  5. Coactivator cross-talk specifies transcriptional output. Marr, M.T., Isogai, Y., Wright, K.J., Tjian, R. Genes Dev. (2006) [Pubmed]
  6. Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Selvaraj, A., Balamurugan, K., Yepiskoposyan, H., Zhou, H., Egli, D., Georgiev, O., Thiele, D.J., Schaffner, W. Genes Dev. (2005) [Pubmed]
  7. Male-specific lethal 2, a dosage compensation gene of Drosophila, undergoes sex-specific regulation and encodes a protein with a RING finger and a metallothionein-like cysteine cluster. Zhou, S., Yang, Y., Scott, M.J., Pannuti, A., Fehr, K.C., Eisen, A., Koonin, E.V., Fouts, D.L., Wrightsman, R., Manning, J.E. EMBO J. (1995) [Pubmed]
  8. Metallothionein genes in Drosophila melanogaster constitute a dual system. Mokdad, R., Debec, A., Wegnez, M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  9. Advantages of a P-element construct containing MtnA sequences for the identification of patterning and cell determination genes in Drosophila melanogaster. Faucheux, M., Netter, S., Bloyer, S., Moussa, M., Boissonneau, E., Lemeunier, F., Wegnez, M., Théodore, L. Mol. Genet. Genomics (2001) [Pubmed]
  10. Molecular evolution of Drosophila metallothionein genes. Lange, B.W., Langley, C.H., Stephan, W. Genetics (1990) [Pubmed]
  11. Molecular and cytogenetic characterization of a metallothionein gene of Drosophila. Maroni, G., Otto, E., Lastowski-Perry, D. Genetics (1986) [Pubmed]
  12. Metallothionein Mto gene of Drosophila melanogaster: structure and regulation. Silar, P., Théodore, L., Mokdad, R., Erraïss, N.E., Cadic, A., Wegnez, M. J. Mol. Biol. (1990) [Pubmed]
  13. A DNA segment controlling metal-regulated expression of the Drosophila melanogaster metallothionein gene Mtn. Otto, E., Allen, J.M., Young, J.E., Palmiter, R.D., Maroni, G. Mol. Cell. Biol. (1987) [Pubmed]
  14. Nucleotide sequence and expression of a Drosophila metallothionein. Lastowski-Perry, D., Otto, E., Maroni, G. J. Biol. Chem. (1985) [Pubmed]
  15. Comparison of several promoters and polyadenylation signals for use in heterologous gene expression in cultured Drosophila cells. Angelichio, M.L., Beck, J.A., Johansen, H., Ivey-Hoyle, M. Nucleic Acids Res. (1991) [Pubmed]
  16. Biochemical characterization of the Drosophila dpp protein, a member of the transforming growth factor beta family of growth factors. Panganiban, G.E., Rashka, K.E., Neitzel, M.D., Hoffmann, F.M. Mol. Cell. Biol. (1990) [Pubmed]
  17. Functional expression of a cloned Drosophila muscarinic acetylcholine receptor in a stable Drosophila cell line. Millar, N.S., Baylis, H.A., Reaper, C., Bunting, R., Mason, W.T., Sattelle, D.B. J. Exp. Biol. (1995) [Pubmed]
  18. A family knockout of all four Drosophila metallothioneins reveals a central role in copper homeostasis and detoxification. Egli, D., Yepiskoposyan, H., Selvaraj, A., Balamurugan, K., Rajaram, R., Simons, A., Multhaup, G., Mettler, S., Vardanyan, A., Georgiev, O., Schaffner, W. Mol. Cell. Biol. (2006) [Pubmed]
  19. Ceramide generation by the Reaper protein is not blocked by the caspase inhibitor, p35. Bose, R., Chen, P., Loconti, A., Grüllich, C., Abrams, J.M., Kolesnick, R.N. J. Biol. Chem. (1998) [Pubmed]
  20. A baculovirus superinfection system: efficient vehicle for gene transfer into Drosophila S2 cells. Lee, D.F., Chen, C.C., Hsu, T.A., Juang, J.L. J. Virol. (2000) [Pubmed]
  21. Expression of metallothionein genes during the post-embryonic development of Drosophila melanogaster. Durliat, M., Bonneton, F., Boissonneau, E., André, M., Wegnez, M. Biometals (1995) [Pubmed]
  22. Metallothionein gene duplications and metal tolerance in natural populations of Drosophila melanogaster. Maroni, G., Wise, J., Young, J.E., Otto, E. Genetics (1987) [Pubmed]
  23. Primary structure of a cadmium-induced metallothionein from the insect Orchesella cincta (Collembola). Hensbergen, P.J., Donker, M.H., Van Velzen, M.J., Roelofs, D., Van Der Schors, R.C., Hunziker, E., Van Straalen, N.M. Eur. J. Biochem. (1999) [Pubmed]
  24. Two metal-binding peptides from the insect Orchesella cincta (Collembola) as a result of metallothionein cleavage. Hensbergen, P.J., Donker, M.H., Hunziker, P.E., van der Schors, R.C., van Straalen, N.M. Insect Biochem. Mol. Biol. (2001) [Pubmed]
 
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