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Gene Review

SMCP  -  sperm mitochondria-associated cysteine...

Homo sapiens

Synonyms: HSMCSGEN1, MCS, MCSP, Sperm mitochondrial-associated cysteine-rich protein
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Disease relevance of SMCP

  • Early detection of SMCP associated with cleft lip and close follow-up permits the prevention of ear problems and the proper management of VPI should it develop [1].
  • For this reason it is important that better information about the symptoms and signs of SMCP is given to doctors, dentists and speech therapists, who refer these patients to the cleft palate clinic [2].
  • Aortic stenosis has been modelled in an in vitro, pulsatile mock circulatory system (MCS) using a porcine valvular prosthesis, and studied with a laser Doppler anemometer (LDA) [3].

Psychiatry related information on SMCP

  • METHODS: This paper compares algorithms developed in the USA and the UK for the calculation of the Physical and Mental Health Summary scores (PCS and MCS) for the SF-36 health status measure [4].

High impact information on SMCP


Biological context of SMCP

  • Similarities in chromosomal location, molecular function, intron-exon structure, and protein organization argue that SMCP originated from an EDC gene and acquired spermatogenic cell-specific transcriptional and translational regulation and a novel cellular function in sperm motility [5].
  • Nucleotide sequence analysis of the human and mouse MCS cDNAs reveals that the 5'- and 3 '-untranslated sequences are more conserved (71%) than the coding sequences (59%) [7].
  • Northern blot and in situ hybridization experiments demonstrate that the expression of the human MCS gene is restricted to haploid spermatids [7].
  • Four mini-Tn10 derivatives bearing the nptII, cat, aacC1 and tet genes along with MCS of the pBluescriptII plasmid were constructed [8].
  • The relatively small size and the presence of the mutant ATS Tn10 transposase gene, fused to Ptac promoter, as well as the versatile MCS of the pBluescriptII plasmid make these vectors a reliable tool for insertion mutagenesis and chromosomal insertion of the cloned DNA fragments [8].

Anatomical context of SMCP

  • The latter were obtained from either atherosclerotic plaques (SMCP) or from media segments (SMCM) of human coronary arteries [9].
  • The results show an interesting difference in the behavior of large conductance Ca(2+)-activated K+ channel in SMCP compared to SMCM with a significantly higher channel activity in human smooth muscle cells obtained from coronary atherosclerotic plaque material [10].
  • In this study, a rat testis cDNA expression library was screened with polyclonal antibodies obtained from rats immunized with isologous spermatozoa to identify and sequence a full-length clone encoding rat sperm mitochondria-associated cysteine-rich protein (SMCP) [6].
  • The mitochondrial capsule selenoprotein (MCS) (HGMW-approved symbol MCSP) is one of three proteins that are important for the maintenance and stabilization of the crescent structure of the sperm mitochondria [7].
  • MCS is a new blood cell separator that combines discontinuous flow features with a new computerized operating system and can be used to harvest either full units of apheresis PC (SDP protocol) or half units of PC together with one to two units of plasma (PLP protocol) [11].

Associations of SMCP with chemical compounds

  • Standard interface plates provide each container with power and data lines, gas supply (controlled CO2, O2 and water vapour concentration; ethylene removal), and--for MCS only--connectors to water reservoirs [12].
  • In the present study, to determine the expression pattern of MCS mRNA in the hamster testis, northern blot and in situ hybridization analyses using digoxigenin-labeled riboprobes for the hamster MCS were performed in the testes of 10-week-old golden hamsters [13].

Analytical, diagnostic and therapeutic context of SMCP

  • These findings demonstrate that SMCP is a sperm autoantigen, recognized following vasectomy, and an isoantigen, recognized by antibodies generated through isologous immunization with sperm [6].
  • Rabbit antiserum produced to rec-SMCP recognized rec-SMCP on Western blots and precisely immunolocalized SMCP to the mid-piece of rat sperm [6].
  • Using the patch-clamp technique, insulin (100 microU/ml) caused a significant increase in BKCa open-state probability in SMCP and HUVEC, whereas no significant changes were observed in SMCM [9].
  • Based on these findings, either a radical dissection and retropositioning of the velar muscles (submucous cleft palate [SMCP repair]) or a Hynes pharyngoplasty (posterior pharyngeal wall augmentation pharyngoplasty) was performed [14].
  • According to the northern blot analysis, hamster MCS was detected as a single transcript of about 1 kb in the testis [13].


  1. The association of submucous cleft palate and clefting of the primary palate. Kono, D., Young, L., Holtmann, B. The Cleft palate journal. (1981) [Pubmed]
  2. Submucous cleft palate. Abyholm, F.E. Scandinavian journal of plastic and reconstructive surgery. (1976) [Pubmed]
  3. Experimental fluid dynamics of aortic stenosis in a model of the human aorta. Yearwood, T.L., Misbach, G.A., Chandran, K.B. Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft für Medizinische Physik and the European Federation of Organisations for Medical Physics. (1989) [Pubmed]
  4. Comparison of UK and US methods for weighting and scoring the SF-36 summary measures. Jenkinson, C. Journal of public health medicine. (1999) [Pubmed]
  5. Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene. Hawthorne, S.K., Goodarzi, G., Bagarova, J., Gallant, K.E., Busanelli, R.R., Olend, W.J., Kleene, K.C. Genomics (2006) [Pubmed]
  6. Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats. Herr, J.C., Thomas, D., Bush, L.A., Coonrod, S., Khole, V., Howards, S.S., Flickinger, C.J. Biol. Reprod. (1999) [Pubmed]
  7. Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP). Aho, H., Schwemmer, M., Tessman, D., Murphy, D., Mattei, G., Engel, W., Adham, I.M. Genomics (1996) [Pubmed]
  8. Mini-Tn10 transposon derivatives for insertion mutagenesis and gene delivery into the chromosome of gram-negative bacteria. Alexeyev, M.F., Shokolenko, I.N. Gene (1995) [Pubmed]
  9. Modulation of Ca2+-activated K+ channels in human vascular cells by insulin and basic fibroblast growth factor. Wiecha, J., Reineker, K., Reitmayer, M., Voisard, R., Hannekum, A., Mattfeldt, T., Waltenberger, J., Hombach, V. Growth Horm. IGF Res. (1998) [Pubmed]
  10. Ca(2+)-activated K+ channels in human smooth muscle cells of coronary atherosclerotic plaques and coronary media segments. Wiecha, J., Schläger, B., Voisard, R., Hannekum, A., Mattfeldt, T., Hombach, V. Basic Res. Cardiol. (1997) [Pubmed]
  11. Evaluation of platelets collected by a new portable apheresis device. Szymanski, I.O., Ciavarella, D., Rososhansky, S., Napychank, P.A., Snyder, E.M. Journal of clinical apheresis. (1993) [Pubmed]
  12. Spaceflight opportunities on the ISS for plant research--the ESA perspective. Brinckmann, E. Advances in space research : the official journal of the Committee on Space Research (COSPAR). (1999) [Pubmed]
  13. Expression pattern of mitochondrial capsule selenoprotein mRNA in the hamster testis. Nam, S.Y., Maeda, S., Fujisawa, M., Kurohmaru, M., Hayashi, Y. J. Vet. Med. Sci. (1998) [Pubmed]
  14. Surgical management of velopharyngeal incompetence in velocardiofacial syndrome. Mehendale, F.V., Birch, M.J., Birkett, L., Sell, D., Sommerlad, B.C. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (2004) [Pubmed]
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