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MeSH Review

Aortic Valve Stenosis

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Disease relevance of Aortic Valve Stenosis


Psychiatry related information on Aortic Valve Stenosis


High impact information on Aortic Valve Stenosis


Chemical compound and disease context of Aortic Valve Stenosis

  • We tested this assumption by examining the influence of short- and long-term changes in load on compliance and filling dynamics using nitroprusside to decrease load in 11 patients with severe aortic stenosis (AS) and ergonovine to increase load in nine normal subjects [11].
  • The effect of 0.1 mg/kg intravenous verapamil on left ventricular relaxation and diastolic mechanics was studied in 10 patients with hypertrophic cardiomyopathy and 13 patients with aortic stenosis [12].
  • Tachycardia induced by atrial pacing provoked myocardial lactate production in half of the patients with aortic stenosis but in none of the patients with aortic insufficiency [13].
  • BACKGROUND: We tested the hypotheses that long-term administration of the angiotensin-converting enzyme (ACE) inhibitor fosinopril will regress hypertrophy, modify the transition to heart failure, and prolong survival in rats with chronic left ventricular (LV) pressure overload due to ascending aortic stenosis [2].
  • However, the time constant T decreased significantly from 79 to 60 msec (p less than .001) in patients with hypertrophic cardiomyopathy but increased significantly from 53 to 68 msec (p less than .025) in those with aortic stenosis [12].

Biological context of Aortic Valve Stenosis


Anatomical context of Aortic Valve Stenosis


Gene context of Aortic Valve Stenosis


Analytical, diagnostic and therapeutic context of Aortic Valve Stenosis


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  2. Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis. Weinberg, E.O., Schoen, F.J., George, D., Kagaya, Y., Douglas, P.S., Litwin, S.E., Schunkert, H., Benedict, C.R., Lorell, B.H. Circulation (1994) [Pubmed]
  3. Intracardiac conduction intervals in children with congenital heart disease: comparison of His bundle studies in 41 normal children and 307 patients with congenital cardiac defects. Levin, A.R., Haft, J.I., Engle, M.A., Ehlers, K.H., Klein, A.A. Circulation (1977) [Pubmed]
  4. Arrhythmias in patients with valvar aortic stenosis, valvar pulmonary stenosis, and ventricular septal defect. Results of 24-hour ECG monitoring. Wolfe, R.R., Driscoll, D.J., Gersony, W.M., Hayes, C.J., Keane, J.F., Kidd, L., O'Fallon, W.M., Pieroni, D.R., Weidman, W.H. Circulation (1993) [Pubmed]
  5. Bacterial endocarditis in patients with aortic stenosis, pulmonary stenosis, or ventricular septal defect. Gersony, W.M., Hayes, C.J., Driscoll, D.J., Keane, J.F., Kidd, L., O'Fallon, W.M., Pieroni, D.R., Wolfe, R.R., Weidman, W.H. Circulation (1993) [Pubmed]
  6. Williams syndrome. Report of a case. Cobo, J., Argüelles, J., Vijande, M., Ibaseta, G. Oral Surg. Oral Med. Oral Pathol. (1992) [Pubmed]
  7. Acquired aortic stenosis in systemic lupus erythematosus. Pritzker, M.R., Ernst, J.D., Caudill, C., Wilson, C.S., Weaver, W.F., Edwards, J.E. Ann. Intern. Med. (1980) [Pubmed]
  8. Beta2-adrenergic receptor overexpression exacerbates development of heart failure after aortic stenosis. Schlüter, K.D. Circulation (2001) [Pubmed]
  9. Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis. Weinberg, E.O., Lee, M.A., Weigner, M., Lindpaintner, K., Bishop, S.P., Benedict, C.R., Ho, K.K., Douglas, P.S., Chafizadeh, E., Lorell, B.H. Circulation (1997) [Pubmed]
  10. Reduced epicardial coronary vasodilator capacity in patients with left ventricular hypertrophy. Vassalli, G., Kaufmann, P., Villari, B., Jakob, M., Boj, H., Kiowski, W., Hess, O.M. Circulation (1995) [Pubmed]
  11. Relation of left ventricular filling dynamics to alterations in load and compliance in patients with and without pressure-overload hypertrophy. Wisenbaugh, T., Harlamert, E., DeMaria, A.N. Circulation (1990) [Pubmed]
  12. Does verapamil improve left ventricular relaxation in patients with myocardial hypertrophy? Hess, O.M., Murakami, T., Krayenbuehl, H.P. Circulation (1986) [Pubmed]
  13. Determinants of left ventricular hypertrophy and oxygen supply in chronic aortic valve disease. Trenouth, R.S., Phelps, N.C., Neill, W.A. Circulation (1976) [Pubmed]
  14. Coronary atherosclerosis is associated with left ventricular dysfunction and dilatation in aortic stenosis. Vekshtein, V.I., Alexander, R.W., Yeung, A.C., Plappert, T., Sutton, M.G., Ganz, P., Selwyn, A.P., Bittl, J.A. Circulation (1990) [Pubmed]
  15. Comparison of echocardiographic methods for assessment of left ventricular shortening and wall stress. Douglas, P.S., Reichek, N., Plappert, T., Muhammad, A., St John Sutton, M.G. J. Am. Coll. Cardiol. (1987) [Pubmed]
  16. The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis. Ortlepp, J.R., Schmitz, F., Mevissen, V., Weiss, S., Huster, J., Dronskowski, R., Langebartels, G., Autschbach, R., Zerres, K., Weber, C., Hanrath, P., Hoffmann, R. Eur. Heart J. (2004) [Pubmed]
  17. Endothelium dependent relaxation in two different models of chronic heart failure and the effect of ibopamine. Buikema, H., van Gilst, W.H., van Veldhuisen, D.J., de Smet, B.J., Scholtens, E., Lie, K.I., Wesseling, H. Cardiovasc. Res. (1993) [Pubmed]
  18. The acute hemodynamic effects of ethacrynic acid and furosemide in patients with chronic postcapillary pulmonary hypertension. Austin, S.M., Schreiner, B.F., Kramer, D.H., Shah, P.M., Yu, P.N. Circulation (1976) [Pubmed]
  19. Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin. Ding, B., Price, R.L., Borg, T.K., Weinberg, E.O., Halloran, P.F., Lorell, B.H. Circ. Res. (1999) [Pubmed]
  20. Progression of aortic stenosis in 394 patients: relation to changes in myocardial and mitral valve dysfunction. Brener, S.J., Duffy, C.I., Thomas, J.D., Stewart, W.J. J. Am. Coll. Cardiol. (1995) [Pubmed]
  21. Reversed shunting across the ductus arteriosus or atrial septum in utero heralds severe congenital heart disease. Berning, R.A., Silverman, N.H., Villegas, M., Sahn, D.J., Martin, G.R., Rice, M.J. J. Am. Coll. Cardiol. (1996) [Pubmed]
  22. Double-inlet single left ventricle: echocardiographic anatomy with emphasis on the morphology of the atrioventricular valves and ventricular septal defect. Bevilacqua, M., Sanders, S.P., Van Praagh, S., Colan, S.D., Parness, I. J. Am. Coll. Cardiol. (1991) [Pubmed]
  23. Shear stress and von Willebrand factor in health and disease. Tsai, H.M. Semin. Thromb. Hemost. (2003) [Pubmed]
  24. Effects of aortic stenosis on renal renin, angiotensin receptor, endothelin and NOS gene expression in rats. Kammerl, M.C., Grimm, D., Kromer, E.P., Jabusch, H.C., Reif, R., Morhard, S., Endemann, D., Fischereder, M., Riegger, G.A., Krämer, B.K. American journal of nephrology. (2002) [Pubmed]
  25. Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Kaden, J.J., Bickelhaupt, S., Grobholz, R., Vahl, C.F., Hagl, S., Brueckmann, M., Haase, K.K., Dempfle, C.E., Borggrefe, M. J. Heart Valve Dis. (2004) [Pubmed]
  26. Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosis. Kaden, J.J., Vocke, D.C., Fischer, C.S., Grobholz, R., Brueckmann, M., Vahl, C.F., Hagl, S., Haase, K.K., Dempfle, C.E., Borggrefe, M. Zeitschrift für Kardiologie. (2004) [Pubmed]
  27. Upregulation of myocardial estrogen receptors in human aortic stenosis. Nordmeyer, J., Eder, S., Mahmoodzadeh, S., Martus, P., Fielitz, J., Bass, J., Bethke, N., Zurbrügg, H.R., Pregla, R., Hetzer, R., Regitz-Zagrosek, V. Circulation (2004) [Pubmed]
  28. Hypertrophic cardiomyopathy. Evaluation by gated cardiac blood pool scanning. Pohost, G.M., Vignola, P.A., McKusick, K.E., Block, P.C., Myers, G.S., Walker, H.J., Copen, D.L., Dinsmore, R.E. Circulation (1977) [Pubmed]
  29. Second natural history study of congenital heart defects. Results of treatment of patients with aortic valvar stenosis. Keane, J.F., Driscoll, D.J., Gersony, W.M., Hayes, C.J., Kidd, L., O'Fallon, W.M., Pieroni, D.R., Wolfe, R.R., Weidman, W.H. Circulation (1993) [Pubmed]
  30. Flow dependence of valve area in aortic stenosis: relation to valve morphology. Shively, B.K., Charlton, G.A., Crawford, M.H., Chaney, R.K. J. Am. Coll. Cardiol. (1998) [Pubmed]
  31. Systolic ejection murmurs in the era of modern cardiology: what do we really know? Murgo, J.P. J. Am. Coll. Cardiol. (1998) [Pubmed]
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