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Disease relevance of Vasectomy


High impact information on Vasectomy

  • Vasectomy and cholesterol [6].
  • In the series there were 17 women aged 39 to 45 years who were otherwise apparently healthy and had had a natural menopause, hysterectomy, or tubal ligation or whose spouse had had a vasectomy [7].
  • Since a high proportion of normal individuals develop antibodies against Sp17 following vasectomy, Sp17 is likely to be a highly immunogenic protein in vivo [8].
  • Systemic biochemical indexes of sympathetic nerve functionplasma catecholamine concentrations and serum dopamine-beta-hydroxylase activitywere correlated with regional indexesnorepinephrine concentration activities of norepinephrine biosynthetic enzymes in the vas deferensānd with blood pressures and pulse rates of 57 men at the time of vasectomy [9].
  • Risk factors were previous exposure to protamine, diabetes, history of receiving protamine-containing insulin, and possibly vasectomy [10].

Chemical compound and disease context of Vasectomy


Biological context of Vasectomy


Anatomical context of Vasectomy


Associations of Vasectomy with chemical compounds

  • Plasma concentrations of testosterone (T), follicle stimulating hormone (FSH), and luteinizing hormone (LH) and percent binding of T to plasma protein (TB) were studied in 16 normal fertile men and in 81 men who had undergone vasectomy from 1 to 5 yr earlier [25].
  • In men who underwent vasectomy 20 years or more ago testosterone was higher than in corresponding controls [26].
  • Irrigation during vasectomy: a comparison between sterile water and the spermicide euflavine [27].
  • Two paired randomized trials testing topical anesthesia with a eutetic mixture of local anesthetics (EMLA cream*) in vasectomy were performed [28].
  • RESULTS: Men who underwent vasectomy 10 to 19 years previously had higher dihydrotestosterone levels than age matched controls [26].

Gene context of Vasectomy

  • In this study to define the boundaries of antigenic regions and epitope recognition pattern, recombinant deletion mutants spanning the entire protein coding sequence and a human NASP cDNA sublibrary were screened with vasectomy patients' sera [29].
  • The concentration of Tf was positively correlated with that of S-Tf-R both in cases with spermatozoa present (r = 0.66, P < 0.001), and in cases with azoospermia of testicular origin (r = 0.51, P < 0.05) but not in vasectomy cases [30].
  • These findings demonstrate that SMCP is a sperm autoantigen, recognized following vasectomy, and an isoantigen, recognized by antibodies generated through isologous immunization with sperm [31].
  • Similarly, HE2 transcriptional and translational products normally expressed in the caput epididymidis were not affected by vasectomy [32].
  • Activin A was also present in seminal plasma in normal men but was undetectable following vasectomy, thus deriving from the testis [33].

Analytical, diagnostic and therapeutic context of Vasectomy


  1. Antisperm antibodies in mouse vasectomy sera react with embryonal teratocarcinoma. Anderson, D.J., Adams, P.H., Hamilton, M.S., Alexander, N.J. J. Immunol. (1983) [Pubmed]
  2. Noncardiac surgery in Eisenmenger syndrome. Ammash, N.M., Connolly, H.M., Abel, M.D., Warnes, C.A. J. Am. Coll. Cardiol. (1999) [Pubmed]
  3. Erectile dysfunction and andropause symptoms in infertile men. O'Brien, J.H., Lazarou, S., Deane, L., Jarvi, K., Zini, A. J. Urol. (2005) [Pubmed]
  4. Angiotensin II dependent testicular fibrosis and effects on spermatogenesis after vasectomy in the rat. Shiraishi, K., Yoshida, K., Fujimiya, T., Naito, K. J. Urol. (2003) [Pubmed]
  5. Short-term chloral hydrate administration and cancer in humans. Haselkorn, T., Whittemore, A.S., Udaltsova, N., Friedman, G.D. Drug safety : an international journal of medical toxicology and drug experience. (2006) [Pubmed]
  6. Vasectomy and cholesterol. Verheugt, F.W., Tijssen, J.G., Boerma, G.J., Maksimovic, P., Miranda, S.I. N. Engl. J. Med. (1981) [Pubmed]
  7. Noncontraceptive estrogens and nonfatal myocardial infarction. Jick, H., Dinan, B., Rothman, K.J. JAMA (1978) [Pubmed]
  8. Sperm protein 17 is a novel cancer-testis antigen in multiple myeloma. Lim, S.H., Wang, Z., Chiriva-Internati, M., Xue, Y. Blood (2001) [Pubmed]
  9. Increased plasma catecholamine concentrations and vas deferens norepinephrine biosynthesis in men with elevated blood pressure. DeQuattro, V., Miura, Y., Lurvey, A., Cosgrove, M., Mendez, R. Circ. Res. (1975) [Pubmed]
  10. A prospective study of the risk of an immediate adverse reaction to protamine sulfate during cardiopulmonary bypass surgery. Weiler, J.M., Gellhaus, M.A., Carter, J.G., Meng, R.L., Benson, P.M., Hottel, R.A., Schillig, K.B., Vegh, A.B., Clarke, W.R. J. Allergy Clin. Immunol. (1990) [Pubmed]
  11. Prostatic cancer, coital rates, vasectomy and testosterone. James, W.H. Journal of biosocial science. (1994) [Pubmed]
  12. Immediate sterility after vasectomy with the use of 0.1% ethacridine lactate. Kamat, D.S., Bharucha, E.K., Sankholkar, P.C. Journal of postgraduate medicine. (1978) [Pubmed]
  13. Combined local-propofol anesthesia with noninvasive positive pressure ventilation in a vasectomy patient with sleep apnea syndrome. Iwama, H., Suzuki, M. Journal of clinical anesthesia. (2003) [Pubmed]
  14. Uridine, xanthine, and urate contents in human seminal plasma. Ronquist, G., Niklasson, F. Arch. Androl. (1984) [Pubmed]
  15. The valve of prednisone in the prevention of scarring after vasovasostomy. Urquhart-Hay, D. The Australian and New Zealand journal of surgery. (1980) [Pubmed]
  16. Status of spermatogenesis and sperm parameters in langur monkeys following long-term vas occlusion with styrene maleic anhydride. Mishra, P.K., Manivannan, B., Pathak, N., Sriram, S., Bhande, S.S., Panneerdoss, S., Lohiya, N.K. J. Androl. (2003) [Pubmed]
  17. Autoimmunity to sperm antigens in vasectomized men. Samuel, T., Kolk, A.H., Rümke, P., Van Lis, J.M. Clin. Exp. Immunol. (1975) [Pubmed]
  18. Effects of abdominal location and epididymal or vasal obstructions either individually or in association on ipsilateral and contralateral testes. A histologic and dna flow cytometric analyses. Türken, A., Okur, D.H., Gedikoğlu, G., Tanyel, F.C. Eur. Urol. (2001) [Pubmed]
  19. Policy considerations for the introduction and promotion of the lactational amenorrhea method: advantages and disadvantages of LAM. Kennedy, K.I., Kotelchuck, M. Journal of human lactation : official journal of International Lactation Consultant Association. (1998) [Pubmed]
  20. Effect of vasectomy on gene expression in the epididymis of cynomolgus monkey. Doiron, K., Légaré, C., Saez, F., Sullivan, R. Biol. Reprod. (2003) [Pubmed]
  21. Differences in the antigen pattern recognized by antisperm antibodies in patients with infertility and vasectomy. Bohring, C., Krause, W. J. Urol. (2001) [Pubmed]
  22. The effects of vasectomy and exercise on cholesterol levels in rat aortas. Westerfield, R.C. Atherosclerosis (1983) [Pubmed]
  23. Human antisperm monoclonal antibodies constructed postvasectomy. Herr, J.C., Fowler, J.E., Howards, S.S., Sigman, M., Sutherland, W.M., Koons, D.J. Biol. Reprod. (1985) [Pubmed]
  24. Activation of mitogen activated protein kinases and apoptosis of germ cells after vasectomy in the rat. Shiraishi, K., Yoshida, K., Fujimiya, T., Naito, K. J. Urol. (2002) [Pubmed]
  25. Long-term effects of vasectomy on pituitary-gonadal function in man. Varma, M.M., Varma, R.R., Johanson, A.J., Kowarski, A., Migeon, C.J. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  26. Early and late long-term effects of vasectomy on serum testosterone, dihydrotestosterone, luteinizing hormone and follicle-stimulating hormone levels. Mo, Z.N., Huang, X., Zhang, S.C., Yang, J.R. J. Urol. (1995) [Pubmed]
  27. Irrigation during vasectomy: a comparison between sterile water and the spermicide euflavine. Gandrup, P., Berthelsen, J.G., Nielsen, O.S. J. Urol. (1982) [Pubmed]
  28. Topical anesthesia with eutetic mixture of local anesthetics cream in vasectomy: 2 randomized trials. Honnens de Lichtenberg, M., Krogh, J., Rye, B., Miskowiak, J. J. Urol. (1992) [Pubmed]
  29. Analysis of the autoimmune epitopes on human testicular NASP using recombinant and synthetic peptides. Batova, I.N., Richardson, R.T., Widgren, E.E., O'Rand, M.G. Clin. Exp. Immunol. (2000) [Pubmed]
  30. The possible meaning of transferrin and its soluble receptors in seminal plasma as markers of the seminiferous epithelium. Zalata, A., Hafez, T., Schoonjans, F., Comhaire, F. Hum. Reprod. (1996) [Pubmed]
  31. Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats. Herr, J.C., Thomas, D., Bush, L.A., Coonrod, S., Khole, V., Howards, S.S., Flickinger, C.J. Biol. Reprod. (1999) [Pubmed]
  32. Vasectomy influences expression of HE1 but not HE2 and HE5 genes in human epididymis. Légaré, C., Verville, N., Sullivan, R. J. Androl. (2004) [Pubmed]
  33. Follistatin and activin A production by the male reproductive tract. Anderson, R.A., Evans, L.W., Irvine, D.S., McIntyre, M.A., Groome, N.P., Riley, S.C. Hum. Reprod. (1998) [Pubmed]
  34. Should vasectomy reversal be performed in men with older female partners? Deck, A.J., Berger, R.E. J. Urol. (2000) [Pubmed]
  35. The relation between antisperm antibodies and testicular alterations after vasectomy and vasovasostomy in Lewis rats. Herr, J.C., Flickinger, C.J., Howards, S.S., Yarbro, S., Spell, D.R., Caloras, D., Gallien, T.N. Biol. Reprod. (1987) [Pubmed]
  36. Vasovasostomy in rabbits after vasectomy or vas occlusion by tantalum clip. Lohiya, N.K., Tiwari, S.N. J. Reprod. Fertil. (1984) [Pubmed]
  37. Structural changes in the human vas deferens after tantalum clip occlusion and conventional vasectomy. Kothari, L.K., Gupta, A.S. Fertil. Steril. (1978) [Pubmed]
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