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Gene Review

LALBA  -  lactalbumin, alpha-

Ovis aries

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High impact information on LALBA

  • The effect on milk production in mice with all endogenous alpha-lactalbumin genes removed and in mice in which the murine genes were then replaced with human homologues is described. alpha-Lactalbumin, and consequently lactose, is essential for normal milk formation, and the human gene is expressed more efficiently than the murine gene [1].
  • Titration of the Ca2+-free binding proteins with 45Ca2+ in a flow-dialysis cell, and of Ca2+-free alpha-lactalbumin used as a control, demonstrated the binding stoichiometry and indicated that Ca2+ ions were bound to the mucosal proteins in dilute buffer at pH 7.5 with a Kd of the order of 10 nM [2].
  • Evidence that prolactin stimulates alpha-lactalbumin production in mannary tissues from premenarcheal rhesus monkeys [3].
  • The amounts of ingested proteins in lambs fed colostrum were much higher than in those fed the milk diet, and their abomasal emptying was faster. alpha-Lactalbumin was highly degraded by abomasal and intestinal proteases, whereas beta-lactoglobulin and in particular the immunoglobulins were less sensitive [4].
  • Sequence of the goat alpha-lactalbumin-encoding gene: comparison with the bovine gene and evidence of related sequences in the goat genome [5].

Biological context of LALBA


Anatomical context of LALBA

  • DNA extracted from 25 hamster-sheep hybrid cell lines was subjected, after Southern blotting, to hybridization with CASB, CASK, LALBA, IGF-1 and AMH cDNA probes [8].
  • The specificity and specific activity of the antibody were monitored by western blotting and demonstrated the presence of highly specific antibodies to ovine alpha-lactalbumin in the treated egg yolk [9].
  • Previous in situ hybridization studies from our laboratory have shown that expression of certain milk protein genes, e.g. alpha-lactalbumin, is very high in most parts of the mammary glands of sheep and cattle, while in other areas containing an abundance of fat globules it is virtually zero (Molenaar et al., 1992) [10].
  • Localisation patterns of the transcription factor Stat5b in the udders from pregnant, lactating and involuting ewes were compared with the expression patterns of two major milk protein genes alpha-lactalbumin and alphaS1 casein [11].
  • Bovine serum albumin (BSA), either untreated or defatted, was found to be better than polyvinylpyrrolidone, ovalbumin, or alpha-lactalbumin, both at stimulating and maintaining motility levels and at reducing the tendency of the washed spermatozoa to stick to glass [12].

Associations of LALBA with chemical compounds


Enzymatic interactions of LALBA


Other interactions of LALBA


Analytical, diagnostic and therapeutic context of LALBA


  1. Production of proteins in the milk of transgenic livestock: problems, solutions, and successes. Colman, A. Am. J. Clin. Nutr. (1996) [Pubmed]
  2. A simple procedure for purifying mammalian duodenal Ca2+-binding proteins on a 100 mg scale and an investigation of the stoichiometry of their high-affinity binding of Ca2+ ions. Bryant, D.T., Andrews, P. Biochem. J. (1983) [Pubmed]
  3. Evidence that prolactin stimulates alpha-lactalbumin production in mannary tissues from premenarcheal rhesus monkeys. Kleinberg, D.L., Todd, J., Niemann, W. Endocrinology (1979) [Pubmed]
  4. Colostrum protein digestion in newborn lambs. Yvon, M., Levieux, D., Valluy, M.C., Pélissier, J.P., Mirand, P.P. J. Nutr. (1993) [Pubmed]
  5. Sequence of the goat alpha-lactalbumin-encoding gene: comparison with the bovine gene and evidence of related sequences in the goat genome. Vilotte, J.L., Soulier, S., Printz, C., Mercier, J.C. Gene (1991) [Pubmed]
  6. Complete nucleotide sequence of ovine alpha-lactalbumin mRNA. Gaye, P., Hue-Delahaie, D., Mercier, J.C., Soulier, S., Vilotte, J.L., Furet, J.P. Biochimie (1987) [Pubmed]
  7. Synthesis and evolution of concentration of beta-lactoglobulin and alpha-lactalbumin from cow and sheep colostrum and milk throughout early lactation. Perez, M.D., Sanchez, L., Aranda, P., Ena, J.M., Oria, R., Calvo, M. Cell. Mol. Biol. (1990) [Pubmed]
  8. Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH). Ghali, M.I., Saidi-Mehtar, N., Guerin, G. Anim. Genet. (1991) [Pubmed]
  9. The use of caprylic acid for the extraction of the immunoglobulin fraction from egg yolk of chickens immunised with ovine alpha-lactalbumin. McLaren, R.D., Prosser, C.G., Grieve, R.C., Borissenko, M. J. Immunol. Methods (1994) [Pubmed]
  10. Expression of the butyrophilin gene, a milk fat globule membrane protein, is associated with the expression of the alpha S1casein gene. Molenaar, A.J., Davis, S.R., Jack, L.J., Wilkins, R.J. Histochem. J. (1995) [Pubmed]
  11. Nuclear localisation of the transcription factor Stat5b is associated with ovine milk protein gene expression during lactation but not during late pregnancy or forced weaning. Molenaar, A.J., Wheeler, T.T., Grigor, M.R. Histochem. J. (2000) [Pubmed]
  12. Bovine serum albumin, sperm motility, and the "dilution effect'. Harrison, R.A., Dott, H.M., Foster, G.C. J. Exp. Zool. (1982) [Pubmed]
  13. Isolation and identification of some major water-soluble peptides in Feta cheese. Michaelidou, A., Alichanidis, E., Urlaub, H., Polychroniadou, A., Zerfiridis, G.K. J. Dairy Sci. (1998) [Pubmed]
  14. Proteolytic degradation of ewe milk proteins during fermentation of yoghurts and storage. El-Zahar, K., Chobert, J.M., Sitohy, M., Dalgalarrondo, M., Haertlé, T. Die Nahrung. (2003) [Pubmed]
  15. Effects of purified bovine whey factors on cellular immune functions in ruminants. Wong, C.W., Seow, H.F., Husband, A.J., Regester, G.O., Watson, D.L. Vet. Immunol. Immunopathol. (1997) [Pubmed]
  16. Expression of alpha-lactalbumin, alpha-S1-casein, and lactoferrin genes is heterogeneous in sheep and cattle mammary tissue. Molenaar, A.J., Davis, S.R., Wilkins, R.J. J. Histochem. Cytochem. (1992) [Pubmed]
  17. Human colostral cells. I. Separation and characterization. Crago, S.S., Prince, S.J., Pretlow, T.G., McGhee, J.R., Mestecky, J. Clin. Exp. Immunol. (1979) [Pubmed]
  18. Two dimensional electrophoresis and immunoblotting for the study of ovine whey protein polymorphism. López-Gálvez, G., Juárez, M., Ramos, M. J. Dairy Res. (1995) [Pubmed]
  19. Characteristics of ruminant mammary epithelial cells grown in primary culture in serum-free medium. Winder, S.J., Turvey, A., Forsyth, I.A. J. Dairy Res. (1992) [Pubmed]
  20. Purification and physicochemical characterization of ovine beta-lactoglobulin and alpha-lactalbumin. El-Zahar, K., Sitohy, M., Dalgalarrondo, M., Choiset, Y., Métro, F., Haertlé, T., Chobert, J.M. Die Nahrung. (2004) [Pubmed]
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