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Gene Review

Ttpa  -  tocopherol (alpha) transfer protein

Mus musculus

Synonyms: Alpha-TTP, Alpha-tocopherol transfer protein, alpha TTP, alpha-TTP
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Disease relevance of Ttpa


High impact information on Ttpa


Biological context of Ttpa


Anatomical context of Ttpa


Associations of Ttpa with chemical compounds

  • In the Ttpa(-/-) mice, low total alpha-tocopherol concentrations were found in plasma (5.4%) and most other tissues (2-20%), but liver concentrations were 39% of those of Ttpa(+/+) mice [8].
  • Deletion of the TTP gene (Ttpa) in mice results in systemic deficiency of alpha-T and neurological dysfunctions described in patients with mutated Ttpa [3].
  • Lipopolysaccharide (LPS) injected intraperitoneally induced increases in lung and liver HO-1 and iNOS, as well as plasma NO(x) in Ttpa(+/+) mice [7].
  • The intraperitoneal administration of MPTP to mice induced a decrease in the striatal levels of dopamine (DA) 3 days after the administration in both alpha-TTP((+/-)) and wild-type mice; these mice were fed an alphaT-deficient diet for 3 weeks before the MPTP administration [9].

Other interactions of Ttpa

  • We therefore analyzed the embryonic expression of apoB, MTP, and alpha-tocopherol transfer protein (alpha-TTP), which have been associated with the assembly and secretion of apoB-containing lipoproteins in the adult liver, at different developmental time points [10].
  • Our results suggest that oxidative stress in the labyrinth region of the placenta is protected by vitamin E during development and that in addition to the hepatic alpha-TTP, which governs plasma alpha-tocopherol level, the uterine alpha-TTP may also play an important role in supplying this vitamin [5].

Analytical, diagnostic and therapeutic context of Ttpa


  1. Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress. Yokota, T., Igarashi, K., Uchihara, T., Jishage, K., Tomita, H., Inaba, A., Li, Y., Arita, M., Suzuki, H., Mizusawa, H., Arai, H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Terasawa, Y., Ladha, Z., Leonard, S.W., Morrow, J.D., Newland, D., Sanan, D., Packer, L., Traber, M.G., Farese, R.V. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein. Gohil, K., Schock, B.C., Chakraborty, A.A., Terasawa, Y., Raber, J., Farese, R.V., Packer, L., Cross, C.E., Traber, M.G. Free Radic. Biol. Med. (2003) [Pubmed]
  4. Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse. Nishida, Y., Yokota, T., Takahashi, T., Uchihara, T., Jishage, K., Mizusawa, H. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  5. Alpha-tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice. Jishage , K., Arita, M., Igarashi, K., Iwata, T., Watanabe, M., Ogawa, M., Ueda, O., Kamada, N., Inoue, K., Arai, H., Suzuki, H. J. Biol. Chem. (2001) [Pubmed]
  6. Vitamin E is essential for mouse placentation but not for embryonic development itself. Jishage, K., Tachibe, T., Ito, T., Shibata, N., Suzuki, S., Mori, T., Hani, T., Arai, H., Suzuki, H. Biol. Reprod. (2005) [Pubmed]
  7. Enhanced inflammatory responses in alpha-tocopherol transfer protein null mice. Schock, B.C., Van der Vliet, A., Corbacho, A.M., Leonard, S.W., Finkelstein, E., Valacchi, G., Obermueller-Jevic, U., Cross, C.E., Traber, M.G. Arch. Biochem. Biophys. (2004) [Pubmed]
  8. Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice. Leonard, S.W., Terasawa, Y., Farese, R.V., Traber, M.G. Am. J. Clin. Nutr. (2002) [Pubmed]
  9. gamma-Tocopherol attenuates MPTP-induced dopamine loss more efficiently than alpha-tocopherol in mouse brain. Itoh, N., Masuo, Y., Yoshida, Y., Cynshi, O., Jishage, K., Niki, E. Neurosci. Lett. (2006) [Pubmed]
  10. Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development. Terasawa, Y., Cases, S.J., Wong, J.S., Jamil, H., Jothi, S., Traber, M.G., Packer, L., Gordon, D.A., Hamilton, R.L., Farese, R.V. J. Lipid Res. (1999) [Pubmed]
  11. Alpha-tocopherol transfer protein is specifically localized at the implantation site of pregnant mouse uterus. Kaempf-Rotzoll, D.E., Igarashi, K., Aoki, J., Jishage, K., Suzuki, H., Tamai, H., Linderkamp, O., Arai, H. Biol. Reprod. (2002) [Pubmed]
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