Gene Review:
GLRX2 - glutaredoxin 2
Homo sapiens
Synonyms:
CGI-133, GRX2, Glutaredoxin-2, mitochondrial, bA101E13.1
- Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor. Lillig, C.H., Berndt, C., Vergnolle, O., Lönn, M.E., Hudemann, C., Bill, E., Holmgren, A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide. Lillig, C.H., Lönn, M.E., Enoksson, M., Fernandes, A.P., Holmgren, A. Proc. Natl. Acad. Sci. U. S. A. (2004)
- Reversible Sequestration of Active Site Cysteines in a 2Fe-2S-bridged Dimer Provides a Mechanism for Glutaredoxin 2 Regulation in Human Mitochondria. Johansson, C., Kavanagh, K.L., Gileadi, O., Oppermann, U. J. Biol. Chem. (2007)
- Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. Gladyshev, V.N., Liu, A., Novoselov, S.V., Krysan, K., Sun, Q.A., Kryukov, V.M., Kryukov, G.V., Lou, M.F. J. Biol. Chem. (2001)
- Expression pattern of human glutaredoxin 2 isoforms: identification and characterization of two testis/cancer cell-specific isoforms. Lönn, M.E., Hudemann, C., Berndt, C., Cherkasov, V., Capani, F., Holmgren, A., Lillig, C.H. Antioxid. Redox. Signal. (2008)
- Identification, expression pattern, and characterization of mouse glutaredoxin 2 isoforms. Hudemann, C., Lönn, M.E., Godoy, J.R., Zahedi Avval, F., Capani, F., Holmgren, A., Lillig, C.H. Antioxid. Redox. Signal. (2009)
- Mitochondrial thioltransferase (glutaredoxin 2) has GSH-dependent and thioredoxin reductase-dependent peroxidase activities in vitro and in lens epithelial cells. Fernando, M.R., Lechner, J.M., L??fgren, S., Gladyshev, V.N., Lou, M.F. FASEB J. (2006)
- Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. Peltoniemi, M., Kaarteenaho-Wiik, R., Säily, M., Sormunen, R., Pääkkö, P., Holmgren, A., Soini, Y., Kinnula, V.L. Hum. Pathol. (2004)
- Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. Lundberg, M., Johansson, C., Chandra, J., Enoksson, M., Jacobsson, G., Ljung, J., Johansson, M., Holmgren, A. J. Biol. Chem. (2001)
- Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase. Johansson, C., Lillig, C.H., Holmgren, A. J. Biol. Chem. (2004)
- Solution structure of Escherichia coli glutaredoxin-2 shows similarity to mammalian glutathione-S-transferases. Xia, B., Vlamis-Gardikas, A., Holmgren, A., Wright, P.E., Dyson, H.J. J. Mol. Biol. (2001)
- Human glutaredoxin 2 affinity tag for recombinant peptide and protein purification. Lundberg, M., Holmgren, A., Johansson, M. Protein Expr. Purif. (2006)