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Gene Review

LUZP4  -  leucine zipper protein 4

Homo sapiens

Synonyms: CT-28, CT-8, CT28, Cancer/testis antigen 28, HOM-TES-85, ...
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Disease relevance of LUZP4

  • We describe here the definition and characterization of antigen CT-8/HOM-TES-85 encoded by a previously unknown gene and identified by serological expression screening using antibodies from a seminoma patient [1].
  • RESULTS: Out of 39 residual masses found by CT 8 relapses could be proven [2].
  • Of 27 patients with a post-chemotherapy 3 cm. or larger mass on CT 8 (30%) had residual tumor (seminoma in 6 and teratoma in 2), whereas necrotic tissue was found in the other 28 patients having a mass smaller than 3 cm [3].
  • We report the development of a three-color fluorescence in situ hybridization (FISH) assay (CT8) to detect mouse sperm carrying structural and numerical chromosomal abnormalities [4].
  • In our case patient, such a giant wooden foreign body was detected neither in the emergency department nor during radiologic investigations (conventional radiograms and standard CT) until the patient underwent multidetector CT 8 days after the related accident [5].

High impact information on LUZP4

  • CT-8/HOM-TES-85 gene is tightly silenced in normal tissues except for testis [1].
  • The aberrant expression of CT-8/HOM-TES-85 in human neoplasms might therefore be involved in cancer associated alterations of transcriptional or post-transcriptional processes and thus may disclose new mechanisms involved in the manifestation of the cancer phenotype [1].
  • The CT8 sperm FISH assay is a promising method for detecting structural chromosome aberrations in mouse sperm with widespread applications in genetics, physiology, and genetic toxicology [4].
  • The CT8 assay was used to measure the frequencies of sperm carrying certain structural aberrations involving chromosome 2 (del2ter, dup2ter, del2cen, dup2cen), disomy 2, disomy 8, and sperm diploidy [4].
  • We validated the CT8 assay by comparing the frequencies of abnormal segregants in sperm of T(2;14) translocation carriers detected by this assay against those detected by chromosome painting cytogenetic analysis of meiosis II spermatocytes [4].

Chemical compound and disease context of LUZP4

  • In particular, a strain (CT28) isolated from a patient with nongonococcal urethritis long treated with erythromycin revealed a MIC greater than 100 micrograms/ml for this antibiotic [6].

Biological context of LUZP4


Anatomical context of LUZP4

  • When compared to a sensitive strain, strain CT28 showed a six-fold reduction in intracellular macrolide influx and accumulation and a reduction in antibiotic binding to ribosomes [6].
  • Head CT 8 hours 50 minutes after injury showed infarctions in the brain stem, cerebellum, and occipital lobes [9].

Associations of LUZP4 with chemical compounds


Analytical, diagnostic and therapeutic context of LUZP4

  • We present a patient in whom clinically unsuspected bilateral pelvic urinomas were diagnosed on a baseline CT 8 weeks after radical hysterectomy [12].


  1. A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing. Türeci, O., Sahin, U., Koslowski, M., Buss, B., Bell, C., Ballweber, P., Zwick, C., Eberle, T., Zuber, M., Villena-Heinsen, C., Seitz, G., Pfreundschuh, M. Oncogene (2002) [Pubmed]
  2. 18FDG-PET following treatment as valid predictor for disease-free survival in Hodgkin's lymphoma. de Wit, M., Bohuslavizki, K.H., Buchert, R., Bumann, D., Clausen, M., Hossfeld, D.K. Ann. Oncol. (2001) [Pubmed]
  3. Surgery for a post-chemotherapy residual mass in seminoma. Herr, H.W., Sheinfeld, J., Puc, H.S., Heelan, R., Bajorin, D.F., Mencel, P., Bosl, G.J., Motzer, R.J. J. Urol. (1997) [Pubmed]
  4. A new FISH assay to simultaneously detect structural and numerical chromosomal abnormalities in mouse sperm. Hill, F.S., Marchetti, F., Liechty, M., Bishop, J., Hozier, J., Wyrobek, A.J. Mol. Reprod. Dev. (2003) [Pubmed]
  5. Detection of a giant wooden foreign body with multidetector computed tomography and multiplanar reconstruction imaging. Kantarci, M., Ogul, H., Karasen, R.M. The American journal of emergency medicine (2007) [Pubmed]
  6. Mechanisms of macrolide resistance in Ureaplasma urealyticum: a study on collection and clinical strains. Palù, G., Valisena, S., Barile, M.F., Meloni, G.A. Eur. J. Epidemiol. (1989) [Pubmed]
  7. Singlet oxygen (1O(2)) disrupts platelet aggregates. Stief, T.W., Feek, U., Ramaswamy, A., Kretschmer, V., Renz, H., Fareed, J. Thromb. Res. (2001) [Pubmed]
  8. Spontaneous internal desynchronization of locomotor activity and body temperature rhythms from plasma melatonin rhythm in rats exposed to constant dim light. Aguzzi, J., Bullock, N.M., Tosini, G. Journal of circadian rhythms [electronic resource]. (2006) [Pubmed]
  9. Traumatic basilar artery occlusion caused by a fracture of the clivus--case report. Sato, S., Iida, H., Hirayama, H., Endo, M., Ohwada, T., Fujii, K. Neurol. Med. Chir. (Tokyo) (2001) [Pubmed]
  10. Carbachol phase shifts the circadian rhythm of locomotor activity in the Djungarian hamster. Wee, B.E., Turek, F.W. Brain Res. (1989) [Pubmed]
  11. MDMA alters the response of the circadian clock to a photic and non-photic stimulus. Colbron, S., Jones, M., Biello, S.M. Brain Res. (2002) [Pubmed]
  12. Bilateral pelvic urinomas following ureteral injury from surgery: lymphocele look-alikes on computed tomography. Gayer, G., Halperin, R., Vasserman, M., Siegel, Y. Emergency radiology. (2005) [Pubmed]
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