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Chemical Compound Review

josamycin     [(2S,3S,4R,6R)-6- [(2R,3S,4R,5R,6R)-6-[[(2R...

Synonyms: Josacine, Josamicina, Josamycine, Josamycinum, Kitasamycin A3, ...
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Disease relevance of EN 141


High impact information on EN 141


Chemical compound and disease context of EN 141


Biological context of EN 141


Anatomical context of EN 141


Associations of EN 141 with other chemical compounds


Gene context of EN 141

  • Addition of RXM (but not JM) at 5.0 and 7.5 microg x mL(-1) significantly suppressed the production of MMP-2 and -9 from NPF induced by TNF-alpha stimulation [27].
  • Josamycin did not show definite time-dependent decreases in IC(50) for CYP 3A4, suggesting that josamycin is neither a quasi-irrversible nor an irreversible inhibitor of CYP3A4 [28].
  • In addition, R compensated the negative effect of josamycin (100 micrograms/ml) on PMN adhesion and on CD18 and CD35 expression [29].
  • In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae [30].
  • Simultaneous determination of the antibiotic levels was performed on the BAL supernatant and the serum and the results compared to those obtained by incubating alveolar macrophages and blood polymorphonuclears at 2 and 8 mg/l. Josamycin concentration was measured using a high pressure liquid chromatography method [21].

Analytical, diagnostic and therapeutic context of EN 141

  • Josamycin pulmonary penetration determined by broncho-alveolar lavage in man [21].
  • A simple, selective and sensitive high-performance liquid chromatographic (HPLC) method has been developed for the measurement of josamycin residues in four porcine tissues (i.e., muscle, liver, kidney and fat) [31].
  • The voltammetric behaviour of josamycin (a macrolide antibiotic) has been studied using direct current (DC(t)) alternating current (AC(t)) and differential pulse polarography (DPP) [32].
  • In hematological examination, the platelet count was significantly (P<0.01) lower in the male groups given 0.02% or more of josamycin and in the 2.5% female group as compared with the control group values in a dose-dependent manner [33].
  • Effects of troleandomycin and josamycin on thyroid hormone and steroid serum levels, liver function tests and microsomal monooxygenases in healthy volunteers: a double blind placebo-controlled study [34].


  1. Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis. Furneri, P.M., Rappazzo, G., Musumarra, M.P., Di Pietro, P., Catania, L.S., Roccasalva, L.S. Antimicrob. Agents Chemother. (2001) [Pubmed]
  2. Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides. Misyurina, O.Y., Chipitsyna, E.V., Finashutina, Y.P., Lazarev, V.N., Akopian, T.A., Savicheva, A.M., Govorun, V.M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  3. In vitro activity of YM133, a new semisynthesized macrolide. Terasawa, T., Watanabe, M., Okubo, T., Mitsuhashi, S. Antimicrob. Agents Chemother. (1991) [Pubmed]
  4. In vitro activity of josamycin against aerobic gram-positive cocci and anaerobes. Westerman, E.L., Williams, T.W., Moreland, N. Antimicrob. Agents Chemother. (1976) [Pubmed]
  5. In vitro susceptibilities of 27 rickettsiae to 13 antimicrobials. Rolain, J.M., Maurin, M., Vestris, G., Raoult, D. Antimicrob. Agents Chemother. (1998) [Pubmed]
  6. Kinetics of macrolide action: the josamycin and erythromycin cases. Lovmar, M., Tenson, T., Ehrenberg, M. J. Biol. Chem. (2004) [Pubmed]
  7. In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. Shimizu, T., Shimizu, S., Hattori, R., Gabazza, E.C., Majima, Y. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  8. Heterogeneity of macrolide-lincosamide-streptogramin B resistance phenotypes in enterococci. Min, Y.H., Jeong, J.H., Choi, Y.J., Yun, H.J., Lee, K., Shim, M.J., Kwak, J.H., Choi, E.C. Antimicrob. Agents Chemother. (2003) [Pubmed]
  9. Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. Kohyama, T., Takizawa, H., Kawasaki, S., Akiyama, N., Sato, M., Ito, K. Antimicrob. Agents Chemother. (1999) [Pubmed]
  10. Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. Morikawa, K., Oseko, F., Morikawa, S., Iwamoto, K. Antimicrob. Agents Chemother. (1994) [Pubmed]
  11. In vitro evaluation of josamycin, spiramycin, and erythromycin against Rickettsia rickettsii and R. conorii. Raoult, D., Roussellier, P., Tamalet, J. Antimicrob. Agents Chemother. (1988) [Pubmed]
  12. In vitro activity and clinical efficacy of clindamycin in the treatment of infections due to anaerobic bacteria. Levison, M.E., Santoro, J., Bran, J.L., Ries, K., Rubin, W. J. Infect. Dis. (1977) [Pubmed]
  13. Predominance of resistant oral streptococci in saliva and the effect of a single course of josamycin or erythromycin. Maskell, J.P., Sefton, A.M., Cannell, H., Kerawala, C., Seymour, A., Sun, Z.M., Williams, J.D. J. Antimicrob. Chemother. (1990) [Pubmed]
  14. Emergence of a 23S rRNA mutation in Mycoplasma hominis associated with a loss of the intrinsic resistance to erythromycin and azithromycin. Pereyre, S., Renaudin, H., Charron, A., Bébéar, C., Bébéar, C.M. J. Antimicrob. Chemother. (2006) [Pubmed]
  15. A new quadruple therapy for Helicobacter pylori using tripotassium dicitrato bismuthate, furazolidone, josamycin and famotidine. Liu, W.Z., Xiao, S.D., Hu, P.J., Lu, H., Cui, Y., Tytgat, G.N. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  16. Comparative efficacy and tolerance of erythromycin and josamycin in the prevention of bacteraemia following dental extraction. Sefton, A.M., Maskell, J.P., Kerawala, C., Cannell, H., Seymour, A., Sun, Z.M., Williams, J.D. J. Antimicrob. Chemother. (1990) [Pubmed]
  17. Effects of josamycin on polymorphonuclear leucocyte chemotaxis. Eyraud, A., Lombard, J.Y., Descotes, J., Laschi-Loquerie, A., Tachon, P., Veysseyre, C., Evreux, J.C. J. Antimicrob. Chemother. (1986) [Pubmed]
  18. In-vivo and in-vitro interference of antibiotics with antigen-specific antibody responses: effect of josamycin. Villa, M.L., Valenti, F., Scaglione, F., Falchi, M., Fraschini, F. J. Antimicrob. Chemother. (1989) [Pubmed]
  19. Comparison of the side effects and gastrointestinal motility observed after administration of erythromycin and josamycin to dogs. Qin, X.Y., Pilot, M.A., Thompson, H.H., Maskell, J.P. J. Antimicrob. Chemother. (1986) [Pubmed]
  20. Synergistic interaction of josamycin with human neutrophils bactericidal function in vitro. Labro, M.T., Babin-Chevaye, C. J. Antimicrob. Chemother. (1989) [Pubmed]
  21. Josamycin pulmonary penetration determined by broncho-alveolar lavage in man. Panteix, G., Harf, R., de Montclos, H., Verdier, M.F., Gaspar, A., Leclercq, M. J. Antimicrob. Chemother. (1988) [Pubmed]
  22. Modification of phagocytosis and cytokine production in peritoneal and splenic murine cells by erythromycin A, azithromycin and josamycin. Ortega, E., Escobar, M.A., Gaforio, J.J., Algarra, I., Alvarez De Cienfuegos, G. J. Antimicrob. Chemother. (2004) [Pubmed]
  23. Application of liquid chromatography-ion trap mass spectrometry to the characterization of the 16-membered ring macrolide josamycin propionate. Govaerts, C., Chepkwony, H.K., Van Schepdael, A., Adams, E., Roets, E., Hoogmartens, J. Journal of mass spectrometry : JMS. (2004) [Pubmed]
  24. Immunochemical similarity of P-450 HFLa, a form of cytochrome P-450 in human fetal livers, to a form of rat liver cytochrome P-450 inducible by macrolide antibiotics. Kitada, M., Igoshi, N., Kamataki, T., Itahashi, K., Imaoka, S., Komori, M., Funae, Y., Rikihisa, T., Kanakubo, Y. Arch. Biochem. Biophys. (1988) [Pubmed]
  25. Simultaneous determination of five macrolide antibiotics in meat by high-performance liquid chromatography. Horie, M., Saito, K., Ishii, R., Yoshida, T., Haramaki, Y., Nakazawa, H. Journal of chromatography. A. (1998) [Pubmed]
  26. Antimicrobial susceptibility of Streptococcus pyogenes and Streptococcus pneumoniae: surveillance from 1993 to 2004 in Central Italy. Montagnani, F., Stolzuoli, L., Zanchi, A., Cresti, S., Cellesi, C. Journal of chemotherapy (Florence, Italy) (2006) [Pubmed]
  27. Suppression of matrix metalloproteinase production from nasal fibroblasts by macrolide antibiotics in vitro. Kanai, K., Asano, K., Hisamitsu, T., Suzaki, H. Eur. Respir. J. (2004) [Pubmed]
  28. Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors. Naritomi, Y., Teramura, Y., Terashita, S., Kagayama, A. Drug Metab. Pharmacokinet. (2004) [Pubmed]
  29. In vitro stimulation of polymorphonuclear cell adhesion by ribomunyl and antibiotic + ribomunyl combinations: effects on CD18, CD35 and CD16 expression. Hbabi, L., Roques, C., Michel, G., Perruchet, A.M., Benoist, H. Int. J. Immunopharmacol. (1993) [Pubmed]
  30. In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae. Biddle, J.W., Thornsberry, C. Antimicrob. Agents Chemother. (1979) [Pubmed]
  31. Determination of josamycin residues in porcine tissues using high-performance liquid chromatography with pre-column derivatization and spectrofluorimetric detection. Leroy, P., Decolin, D., Nicolas, A., Archimbault, P. The Analyst. (1994) [Pubmed]
  32. Voltammetric determination of josamycin (a macrolide antibiotic) in dosage forms and spiked human urine. Belal, F., Al-Majed, A., Ibrahim, K.E., Khalil, N.Y. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  33. A chronic toxicity study of josamycin in F344 rats. Kasahara, K., Nishikawa, A., Furukawa, F., Ikezaki, S., Tanakamaru, Z., Lee, I.S., Imazawa, T., Hirose, M. Food Chem. Toxicol. (2002) [Pubmed]
  34. Effects of troleandomycin and josamycin on thyroid hormone and steroid serum levels, liver function tests and microsomal monooxygenases in healthy volunteers: a double blind placebo-controlled study. Uzzan, B., Nicolas, P., Perret, G., Vassy, R., Tod, M., Petitjean, O. Fundamental & clinical pharmacology. (1991) [Pubmed]
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