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PIPOX  -  pipecolic acid oxidase

Homo sapiens

Synonyms: L-pipecolate oxidase, L-pipecolic acid oxidase, LPIPOX, PSO, Peroxisomal sarcosine oxidase
 
 
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Disease relevance of PIPOX

  • Both purified sarcosine oxidase and a recombinant fusion protein synthesized in Escherichia coli contain a covalently bound flavin, metabolize sarcosine, L-pipecolic acid, and L-proline, and cross-react with antibodies raised against L-pipecolic acid oxidase from monkey liver [1].
  • Patients with psoriasis (PSO; n=23), a TH(1)-mediated inflammatory (autoimmune) skin disease and healthy controls (n=25) were exposed to a standardized laboratory stressor (TSST) which mainly consists of a free speech and a mental arithmetic task in front of an audience [2].
  • PATIENTS AND METHODS: A prospective cross-sectional and matched study of 1356 adult outpatients to compare the health-related quality of life (HRQL) profile in chronic urticaria (466 CU), psoriasis (464 PSO) and atopic dermatitis (426 AD), using the VQ-Dermato, a multidimensional instrument in French validated for CSDs [3].
  • Samples were obtained when abnormal nails were found: distal and lateral subungual onychomycosis (DLSO), white superficial, proximal subungual (PSO), endonyx, and total dystrophic (TDO) [4].
  • PSO, a rare pattern in immunocompetent subjects, was exclusively found in the lupus group [4].
 

Psychiatry related information on PIPOX

  • The 'physical discomfort' dimension was more degraded in AD and CU than in PSO (P < 0.001), and 'leisure activities' more in PSO than in CU (P < 0.001). 'Self-perception' and 'treatment-induced restrictions' dimensions were much less affected in CU than in PSO and AD (P < 0.001) [3].
 

High impact information on PIPOX

  • L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases [5].
  • L-Pipecolic acid oxidase activity is deficient in patients with peroxisome biogenesis disorders (PBDs) [5].
  • The cDNA was cloned with the use of a reverse genetics approach based on the amino acid sequence obtained from purified L-pipecolic acid oxidase from monkey [5].
  • However, PSO patients showed elevated epinephrine (F(3,102)=4.7; p<0.005) and norepinephrine (F(3,135)=2.7; p<0.05) levels in response to the stress test when compared to the controls [2].
  • Analysis of cortisol and ACTH levels after the stress test yielded no significant differences between PSO subjects and controls indicating no altered HPA axis function in this patient group [2].
 

Biological context of PIPOX

 

Anatomical context of PIPOX

 

Associations of PIPOX with chemical compounds

 

Other interactions of PIPOX

 

Analytical, diagnostic and therapeutic context of PIPOX

References

  1. Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase. Reuber, B.E., Karl, C., Reimann, S.A., Mihalik, S.J., Dodt, G. J. Biol. Chem. (1997) [Pubmed]
  2. Endocrine stress responses in TH1-mediated chronic inflammatory skin disease (psoriasis vulgaris)--do they parallel stress-induced endocrine changes in TH2-mediated inflammatory dermatoses (atopic dermatitis)? Buske-Kirschbaum, A., Ebrecht, M., Kern, S., Hellhammer, D.H. Psychoneuroendocrinology (2006) [Pubmed]
  3. Comparative study of the impact of chronic urticaria, psoriasis and atopic dermatitis on the quality of life. Grob, J.J., Revuz, J., Ortonne, J.P., Auquier, P., Lorette, G. Br. J. Dermatol. (2005) [Pubmed]
  4. Onychomycosis in systemic lupus erythematosus: a case control study. Tlacuilo-Parra, A., Guevara-Gutierrez, E., Mayorga, J., Garcia-De La Torre, I., Salazar-Paramo, M. J. Rheumatol. (2003) [Pubmed]
  5. L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases. Dodt, G., Kim, D.G., Reimann, S.A., Reuber, B.E., McCabe, K., Gould, S.J., Mihalik, S.J. Biochem. J. (2000) [Pubmed]
  6. Gonadotropin effects on chromosomal normality of hamster preimplantation embryos. Sengoku, K., Dukelow, R.W. Biol. Reprod. (1988) [Pubmed]
  7. Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae. Brendel, M., Bonatto, D., Strauss, M., Revers, L.F., Pungartnik, C., Saffi, J., Henriques, J.A. Mutat. Res. (2003) [Pubmed]
  8. Molecular cloning and expression of human L-pipecolate oxidase. IJlst, L., de Kromme, I., Oostheim, W., Wanders, R.J. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  9. Identification of L-pipecolate oxidase in human liver and its deficiency in the Zellweger syndrome. Wanders, R.J., Romeyn, G.J., van Roermund, C.W., Schutgens, R.B., van den Bosch, H., Tager, J.M. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  10. Assay for L-pipecolate oxidase activity in human liver: detection of enzyme deficiency in hyperpipecolic acidaemia. Rao, V.V., Chang, Y.F. Biochim. Biophys. Acta (1992) [Pubmed]
  11. The human L-pipecolic acid oxidase is similar to bacterial monomeric sarcosine oxidases rather than D-amino acid oxidases. Dodt, G., Kim, D., Reimann, S., McCabe, K., Gould, S.J., Mihalik, S.J. Cell Biochem. Biophys. (2000) [Pubmed]
  12. Lysine biosynthesis in Rhodotorula glutinis: properties of pipecolic acid oxidase. Kinzel, J.J., Bhattacharjee, J.K. J. Bacteriol. (1982) [Pubmed]
  13. L-pipecolate oxidase: a distinct peroxisomal enzyme in man. Wanders, R.J., Romeyn, G.J., Schutgens, R.B., Tager, J.M. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  14. Adrenoleukodystrophy and other peroxisomal disorders that affect the nervous system, including new observations on L-pipecolic acid oxidase in primates. Moser, H.W., Mihalik, S.J., Watkins, P.A. Brain Dev. (1989) [Pubmed]
 
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