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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HOOK1  -  hook microtubule-tethering protein 1

Homo sapiens

Synonyms: HK1, Protein Hook homolog 1, h-hook1, hHK1
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Disease relevance of HOOK1

  • Therefore, the human HOOK1 gene could serve as a candidate gene for male infertility due to teratozoospermia or decapitation defects [1].
  • Unlika in parental or single-genotype siblings, in which TPA promotion-elicited papillomas remained benign, TPA promotion elicited autonomous papillomas in HK1 less than, with dotras/alpha mice and exhibited a novel susceptibility to malignant conversion [2].
  • On Spearman correlation analysis an isotype from HK1 demonstrated a significant increased adherence to BECs and CSH during HIV disease progression whereas no such correlation was noted for the remaining isotypes studied [3].

High impact information on HOOK1

  • Our previous studies demonstrated that HK-1, by promoting proliferation, survival, and possibly maturation of B-cell precursors, plays an important role in B lymphopoiesis [4].
  • Here we present data showing that HK-1 also influences T-cell development at a similar stage of differentiation [4].
  • A channel recently cloned from human ventricular myocardium (Kv1.4, HK1) produces a rapidly inactivating K+ current, which has phenotypic similarities to the 4-aminopyridine-sensitive component of ITO [5].
  • Human keratin 1 (HK1) expression is associated with the loss of mitotic activity in epidermal keratinocytes and restricted to an intermediate stage of terminal differentiation [6].
  • Through a comparison with other mouse models, the characteristics of the HK1-Shh transgenic mice suggest that the precise timing and site of Shh expression are key in dictating the resultant skin and tumour phenotype [7].

Biological context of HOOK1

  • Partial methylation was observed in 1 NPC cell line HK1 showing dramatic decreased in TIG1 expression [8].
  • Regional mapping of the locus for hexokinase-1 (HK1) to 10p11 equals to q23 by gene dosage in human fibroblasts [9].
  • The results showed that the IC50 of NPC/HK1 cells for TNP-470 was 3.8 times higher than that of HDMEC [10].
  • This further supports the observation that cell death in PDT-treated NPC/HK1 tumors was by necrosis [11].
  • Similarly, there was up-regulation of MMP1 mRNA expression in hypericin-PDT-treated NPC/HK1-tumors [12].

Anatomical context of HOOK1

  • PPT-C, the gene encoding the novel tachykinin peptide hemokinin-1 (HK-1), was present in trace amounts in the uteri from both pregnant and nonpregnant women [13].
  • The colorimetric MTT assay was used to evaluate the IC50 values of NPC/HK1 cells and human dermal microvascular endothelial cells (HDMEC) for TNP-470 [10].
  • These results are in agreement with the evidence derived from another similar patient and strongly support the idea of gene dosage effect of HK1 in the erythrocytes of 10p trisomics [14].

Associations of HOOK1 with chemical compounds

  • Flow cytometry experiments revealed that quercetin-induced apoptosis during the first 24 h followed by necrosis in both HK1 and CNE2 [15].
  • When cetuximab was combined with cisplatin or paclitaxel in the HK1 and HONE-1 cell lines, an additive enhancement of cytotoxic drug activity was demonstrated [16].

Analytical, diagnostic and therapeutic context of HOOK1


  1. The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse. Mendoza-Lujambio, I., Burfeind, P., Dixkens, C., Meinhardt, A., Hoyer-Fender, S., Engel, W., Neesen, J. Hum. Mol. Genet. (2002) [Pubmed]
  2. Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation. Wang, X.J., Greenhalgh, D.A., Roop, D.R. Mol. Carcinog. (2000) [Pubmed]
  3. Adhesion and cell-surface-hydrophobicity of sequentially isolated genetic isotypes of Candida albicans in an HIV-infected Southern Chinese cohort. Samaranayake, Y.H., Samaranayake, L.P., Yau, J.Y., Ellepola, A.N., Anil, S., Yeung, K.W. Mycoses (2003) [Pubmed]
  4. T-cell developmental blockage by tachykinin antagonists and the role of hemokinin 1 in T lymphopoiesis. Zhang, Y., Paige, C.J. Blood (2003) [Pubmed]
  5. Modulation of an inactivating human cardiac K+ channel by protein kinase C. Murray, K.T., Fahrig, S.A., Deal, K.K., Po, S.S., Hu, N.N., Snyders, D.J., Tamkun, M.M., Bennett, P.B. Circ. Res. (1994) [Pubmed]
  6. Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element. Lu, B., Rothnagel, J.A., Longley, M.A., Tsai, S.Y., Roop, D.R. J. Biol. Chem. (1994) [Pubmed]
  7. Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis. Ellis, T., Smyth, I., Riley, E., Bowles, J., Adolphe, C., Rothnagel, J.A., Wicking, C., Wainwright, B.J. Dev. Biol. (2003) [Pubmed]
  8. Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma. Kwong, J., Lo, K.W., Chow, L.S., Chan, F.L., To, K.F., Huang, D.P. Int. J. Cancer (2005) [Pubmed]
  9. Regional mapping of the locus for hexokinase-1 (HK1) to 10p11 equals to q23 by gene dosage in human fibroblasts. Gitelman, B.J., Simpson, N.E. Hum. Genet. (1982) [Pubmed]
  10. Anti-tumor effect of angiogenesis inhibitor TNP-470 on the human nasopharyngeal carcinoma cell line NPC/HK1. Qian, C.N., Min, H.Q., Lin, H.L., Feng, G.K., Ye, Y.L., Wang, L.G., Kuang, Z.J. Oncology (1999) [Pubmed]
  11. Hypericin-mediated photodynamic therapy induces lipid peroxidation and necrosis in nasopharyngeal cancer. Du, H.Y., Olivo, M., Tan, B.K., Bay, B.H. Int. J. Oncol. (2003) [Pubmed]
  12. Modulation of Matrix metalloproteinase-1 in nasopharyngeal cancer cells by photoactivation of hypericin. Du, H., Olivo, M., Mahendran, R., Bay, B.H. Int. J. Oncol. (2004) [Pubmed]
  13. Tachykinins and tachykinin receptors in human uterus. Patak, E., Candenas, M.L., Pennefather, J.N., Ziccone, S., Lilley, A., Martín, J.D., Flores, C., Mantecón, A.G., Story, M.E., Pinto, F.M. Br. J. Pharmacol. (2003) [Pubmed]
  14. Evidence of gene dosage effect for HK 1 in the red cells of a patient with trisomy 10pter leads to p13. Dallapiccola, B., Serena Lungarotti, M., Magnani, M., Dacha, M. Ann. Genet. (1981) [Pubmed]
  15. Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions. Ong, C.S., Tran, E., Nguyen, T.T., Ong, C.K., Lee, S.K., Lee, J.J., Ng, C.P., Leong, C., Huynh, H. Oncol. Rep. (2004) [Pubmed]
  16. Antitumor effect and enhancement of cytotoxic drug activity by cetuximab in nasopharyngeal carcinoma cells. Sung, F.L., Poon, T.C., Hui, E.P., Ma, B.B., Liong, E., To, K.F., Huang, D.P., Chan, A.T. In Vivo (2005) [Pubmed]
  17. Characterization of human genomic yeast artificial chromosome inserts containing hexokinase 1 coding information on chromosome 10. Gelb, B.D., Worley, K.C., Griffin, L.D., Adams, V., Chinault, A.C., McCabe, E.R. Biochem. Med. Metab. Biol. (1992) [Pubmed]
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