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Gene Review

PDGFB  -  platelet-derived growth factor beta...

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Disease relevance of PDGFB


High impact information on PDGFB


Biological context of PDGFB

  • Down-regulation of PDGF-B gene expression by small interfering RNAs completely inhibited the PEDF-induced DNA synthesis in pericytes [9].
  • However, transfection of ECs with hybrid promoter constructs containing the SV40 sequence promoter downstream of the SSRE or the -153 PDGF-B promoter sequence bearing a mutation in the SSRE demonstrated that the SSRE was not necessary for inducible reporter gene expression in ECs exposed to cyclic strain [10].
  • Antisense oligodeoxyribonucleotides complementary to mRNA encoding a receptor for AGE were found to reverse both the PDGF-B upregulation and the AGE-induced DNA synthesis [3].

Anatomical context of PDGFB


Associations of PDGFB with chemical compounds


Other interactions of PDGFB


  1. Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment. Seo, M.S., Okamoto, N., Vinores, M.A., Vinores, S.A., Hackett, S.F., Yamada, H., Yamada, E., Derevjanik, N.L., LaRochelle, W., Zack, D.J., Campochiaro, P.A. Am. J. Pathol. (2000) [Pubmed]
  2. FGF2-Targeted adenovirus encoding platelet-derived growth factor-B enhances de novo tissue formation. Chandler, L.A., Doukas, J., Gonzalez, A.M., Hoganson, D.K., Gu, D.L., Ma, C., Nesbit, M., Crombleholme, T.M., Herlyn, M., Sosnowski, B.A., Pierce, G.F. Mol. Ther. (2000) [Pubmed]
  3. Advanced glycation endproducts-receptor interactions stimulate the growth of human pancreatic cancer cells through the induction of platelet-derived growth factor-B. Yamamoto, Y., Yamagishi, S., Hsu, C.C., Yamamoto, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  4. Simian sarcoma virus transformation of normal rat kidney fibroblasts is associated with markedly increased basic fibroblast growth factor expression. Milner, P.G. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  5. Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress. Khachigian, L.M., Resnick, N., Gimbrone, M.A., Collins, T. J. Clin. Invest. (1995) [Pubmed]
  6. Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. Malek, A.M., Gibbons, G.H., Dzau, V.J., Izumo, S. J. Clin. Invest. (1993) [Pubmed]
  7. 8-Methoxypsoralen and longwave ultraviolet irradiation are a novel antiproliferative combination for vascular smooth muscle. March, K.L., Patton, B.L., Wilensky, R.L., Hathaway, D.R. Circulation (1993) [Pubmed]
  8. Induction of platelet-derived growth factor B-chain expression by transforming growth factor-beta involves transactivation by Smads. Taylor, L.M., Khachigian, L.M. J. Biol. Chem. (2000) [Pubmed]
  9. Pigment epithelium-derived factor (PEDF) promotes growth of pericytes through autocrine production of platelet-derived growth factor-B. Yamagishi, S., Nakamura, K., Takenaka, K., Matsui, T., Jinnouchi, Y., Imaizumi, T. Microvasc. Res. (2005) [Pubmed]
  10. Regulation of PDGF-B in endothelial cells exposed to cyclic strain. Sumpio, B.E., Du, W., Galagher, G., Wang, X., Khachigian, L.M., Collins, T., Gimbrone, M.A., Resnick, N. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  11. Synergistic effect of growth factors on cell outgrowth from explants of rabbit anterior cruciate and medial collateral ligaments. Lee, J., Green, M.H., Amiel, D. J. Orthop. Res. (1995) [Pubmed]
  12. Culture of large vessel endothelial cells on floating collagen gels promotes a phenotype characteristic of endothelium in vivo. Beck, L.H., Goodwin, A.M., D'Amore, P.A. Differentiation (2004) [Pubmed]
  13. Endothelial gene regulation by laminar shear stress. Resnick, N., Yahav, H., Khachigian, L.M., Collins, T., Anderson, K.R., Dewey, F.C., Gimbrone, M.A. Adv. Exp. Med. Biol. (1997) [Pubmed]
  14. Angiotensin II stimulates platelet-derived growth factor-B gene expression in cultured retinal pericytes through intracellular reactive oxygen species generation. Amano, S., Yamagishi, S., Inagaki, Y., Okamoto, T. International journal of tissue reactions. (2003) [Pubmed]
  15. Direct assignment of disulfide bonds by Edman degradation of selected peptide fragments. Haniu, M., Acklin, C., Kenney, W.C., Rohde, M.F. Int. J. Pept. Protein Res. (1994) [Pubmed]
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