Disease relevance of POLA1

• Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study [1].
• Risk factors for cortical, nuclear, and posterior subcapsular cataracts: the POLA study. Pathologies Oculaires Liées à l'Age [2].
• Relationships between physical activity, obesity and diabetes mellitus in a French elderly population: the POLA study. Pathologies Oculaires lieés á l' Age [3].
• The findings appear to confirm the theoretical analysis of the eye movement disorder in internuclear ophthalmoplegia provided by Pola and Robinson as modified by recent experimental work in primates [4].

High impact information on POLA1

• Our monoclonal antibody had no effect on homogeneous human uracil DNA glycosylase activity but severely inhibited the activity of the homogeneous human DNA polymerase alpha catalytic subunit [5].
• PURPOSE: To assess the associations of plasma lutein and zeaxanthin and other carotenoids with the risk of age-related maculopathy (ARM) and cataract in the population-based Pathologies Oculaires Liées à l'Age (POLA) Study. METHODS: Retinal photographs were graded according to the international classification [1].
• PARTICIPANTS: At baseline, the Age-Related Eye Diseases (Pathologies Oculaires Liées à l'Age, POLA) Study included 2584 residents of Sète (southern France) aged 60 years or older [6].
• Associations of cataract with antioxidant enzymes and other risk factors: the French Age-Related Eye Diseases (POLA) Prospective Study [6].
• Identification of YAC and cosmid clones encompassing the ZFX-POLA region using irradiation hybrid cell lines [7].

Biological context of POLA1

• Previous studies have shown that STS and ZFX escape X-inactivation whereas POLA undergoes inactivation [8].
• In this experiment, sequences of the gene encoding the DNA polymerase alpha catalytic polypeptide (POLA) were analysed phylogenetically in combination with those encoding the RNA polymerase II largest subunit gene (RPOIILS) to infer a comprehensive phylogeny of Leishmania [9].
• A DNA polymerase alpha catalytic subunit is purified independently from the tissues at meiotic prometaphase I of a basidiomycete, Coprinus cinereus [10].
• To study DNA polymerase alpha during meiosis, we cloned cDNAs for the C. cinereus DNA polymerase alpha catalytic subunit (p140) and C. cinereus primase small subunit (p48) [11].

Associations of POLA1 with chemical compounds

• Associations of age, smoking habits and diabetes with plasma vitamin C of elderly of the POLA study [12].

Other interactions of POLA1

• Five YACs from the 12-YAC cluster had been previously recognized by DNA polymerase alpha (POLA) [7].
• Associations of antioxidant enzymes with cataract and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liées à l'Age [13].

Analytical, diagnostic and therapeutic context of POLA1

• The amplification by PCR of 12 markers located between POLA and DXS704 using genomic DNA from 192 MR males led to the identification, in a 9 year old mentally retarded boy, of a microdeletion which extends from DXS1202 to DXS1065 [14].
• DESIGN AND SUBJECTS: We conducted a cross-sectional study on 1113 men and 1419 women aged 60 y or more, participating in the POLA Study. RESULTS: The prevalence of diabetes was two-fold higher in men than in women (19.1% and 9.3%, respectively) [3].
• DESIGN: The "Pathologies Oculaires Liées à l'Age" (POLA) Study, a population-based prospective cohort study [15].

References