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Gene Review

POLA1  -  polymerase (DNA directed), alpha 1,...

Homo sapiens

Synonyms: DNA polymerase alpha catalytic subunit, DNA polymerase alpha catalytic subunit p180, NSX, POLA, p180
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Disease relevance of POLA1


High impact information on POLA1


Biological context of POLA1


Associations of POLA1 with chemical compounds

  • Associations of age, smoking habits and diabetes with plasma vitamin C of elderly of the POLA study [12].

Other interactions of POLA1


Analytical, diagnostic and therapeutic context of POLA1

  • The amplification by PCR of 12 markers located between POLA and DXS704 using genomic DNA from 192 MR males led to the identification, in a 9 year old mentally retarded boy, of a microdeletion which extends from DXS1202 to DXS1065 [14].
  • DESIGN AND SUBJECTS: We conducted a cross-sectional study on 1113 men and 1419 women aged 60 y or more, participating in the POLA Study. RESULTS: The prevalence of diabetes was two-fold higher in men than in women (19.1% and 9.3%, respectively) [3].
  • DESIGN: The "Pathologies Oculaires Liées à l'Age" (POLA) Study, a population-based prospective cohort study [15].


  1. Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study. Delcourt, C., Carrière, I., Delage, M., Barberger-Gateau, P., Schalch, W. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  2. Risk factors for cortical, nuclear, and posterior subcapsular cataracts: the POLA study. Pathologies Oculaires Liées à l'Age. Delcourt, C., Cristol, J.P., Tessier, F., Léger, C.L., Michel, F., Papoz, L. Am. J. Epidemiol. (2000) [Pubmed]
  3. Relationships between physical activity, obesity and diabetes mellitus in a French elderly population: the POLA study. Pathologies Oculaires lieés á l' Age. Defay, R., Delcourt, C., Ranvier, M., Lacroux, A., Papoz, L. Int. J. Obes. Relat. Metab. Disord. (2001) [Pubmed]
  4. An electrooculographic study of internuclear ophthalmoplegia. Kirkham, T.H., Katsarkas, A. Ann. Neurol. (1977) [Pubmed]
  5. Physical association of the human base-excision repair enzyme uracil DNA glycosylase with the 70,000-dalton catalytic subunit of DNA polymerase alpha. Seal, G., Sirover, M.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Associations of cataract with antioxidant enzymes and other risk factors: the French Age-Related Eye Diseases (POLA) Prospective Study. Delcourt, C., Carrière, I., Delage, M., Descomps, B., Cristol, J.P., Papoz, L. Ophthalmology (2003) [Pubmed]
  7. Identification of YAC and cosmid clones encompassing the ZFX-POLA region using irradiation hybrid cell lines. Francis, F., Benham, F., See, C.G., Fox, M., Ishikawa-Brush, Y., Monaco, A.P., Weiss, B., Rappold, G., Hamvas, R.M., Lehrach, H. Genomics (1994) [Pubmed]
  8. Physical mapping of loci in the distal half of the short arm of the human X chromosome: implications for the spreading of X-chromosome inactivation. Wang, J.C., Passage, M.B., Ellison, J., Becker, M.A., Yen, P.H., Shapiro, L.J., Mohandas, T.K. Somat. Cell Mol. Genet. (1992) [Pubmed]
  9. Evolution of the genus Leishmania revealed by comparison of DNA and RNA polymerase gene sequences. Croan, D.G., Morrison, D.A., Ellis, J.T. Mol. Biochem. Parasitol. (1997) [Pubmed]
  10. A DNA polymerase alpha catalytic subunit is purified independently from the tissues at meiotic prometaphase I of a basidiomycete, Coprinus cinereus. Sawado, T., Sakaguchi, K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  11. Dissociation of DNA polymerase alpha-primase complex during meiosis in Coprinus cinereus. Namekawa, S., Hamada, F., Sawado, T., Ishii, S., Nara, T., Ishizaki, T., Ohuchi, T., Arai, T., Sakaguchi, K. Eur. J. Biochem. (2003) [Pubmed]
  12. Associations of age, smoking habits and diabetes with plasma vitamin C of elderly of the POLA study. Birlouez-Aragon, I., Delcourt, C., Tessier, F., Papoz, L. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (2001) [Pubmed]
  13. Associations of antioxidant enzymes with cataract and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liées à l'Age. Delcourt, C., Cristol, J.P., Léger, C.L., Descomps, B., Papoz, L. Ophthalmology (1999) [Pubmed]
  14. Identification by STS PCR screening of a microdeletion in Xp21.3-22.1 associated with non-specific mental retardation. Billuart, P., Vinet, M.C., des Portes, V., Llense, S., Richard, L., Moutard, M.L., Recan, D., Brüls, T., Bienvenu, T., Kahn, A., Beldjord, C., Chelly, J. Hum. Mol. Genet. (1996) [Pubmed]
  15. The three-year incidence of age-related macular degeneration: the "Pathologies Oculaires Liées à l'Age" (POLA) prospective study. Delcourt, C., Lacroux, A., Carrière, I. Am. J. Ophthalmol. (2005) [Pubmed]
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