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Gene Review

Cltc  -  clathrin, heavy chain (Hc)

Rattus norvegicus

Synonyms: Clathrin heavy chain 1
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Disease relevance of Cltc


High impact information on Cltc

  • This Triton X-100-insoluble membrane subfraction contains only 5% of the total plasma membrane protein and yet contains all of the clathrin heavy chain associated with plasma membrane, as detected by immunoblotting with a monoclonal antibody [2].
  • Immunofluorescence microscopy has been used to demonstrate that X22, a monoclonal antibody specific for clathrin heavy chain, localizes in repetitive bands that appear soon after the fusion of skeletal myoblasts into multinucleate fibers [3].
  • (4) Immunoblot analysis of myotube lysates reveals a single band with an electrophoretic mobility identical to the 180,000-Da clathrin heavy chain [3].
  • In the experiments reported here we have analyzed whether genes recently identified as kainate-induced in the rat dentate gyrus and coding for secretogranin II, clathrin heavy chain and heat shock cognate protein 70 can be characterized by a secondary, i.e. possibly inducible transcription factor-dependent mode of activation [4].
  • Comparison by two-dimensional mapping of the 220 kDa in brain clathrin with the clathrin heavy chain (180 kDa) polypeptide showed they were different proteins, but the 220 kDa polypeptide present in rat liver tight junctions was highly similar to the 220 kDa present in bovine brain clathrin preparations.(ABSTRACT TRUNCATED AT 250 WORDS)[5]

Biological context of Cltc


Anatomical context of Cltc

  • These studies show that the clathrin heavy chain is a primary site of the clathrin cage receptive to intracellular interactions and furthermore suggest that the clathrin heavy chain consists of domains of biochemical specificity which may selectively affect the activities of coated vesicles [7].
  • On immunocytochemical analysis of PC12 cells with an anti-clathrin heavy chain antibody, enhanced staining of the clathrin heavy chain was observed concomitantly with neurite outgrowth initiated by ZLLLal, but not by NGF [8].

Other interactions of Cltc


Analytical, diagnostic and therapeutic context of Cltc


  1. Role of clathrin in the regulated secretory pathway of pancreatic beta-cells. Molinete, M., Dupuis, S., Brodsky, F.M., Halban, P.A. J. Cell. Sci. (2001) [Pubmed]
  2. A highly phosphorylated subpopulation of insulin-like growth factor II/mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction. Corvera, S., Folander, K., Clairmont, K.B., Czech, M.P. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  3. Localization of anti-clathrin antibody in the sarcomere and sensitivity of myofibril structure to chloroquine suggest a role for clathrin in myofibril assembly. Kaufman, S.J., Bielser, D., Foster, R.F. Exp. Cell Res. (1990) [Pubmed]
  4. Kainate-evoked secondary gene expression in the rat hippocampus. Konopka, D., Nowicka, D., Filipkowski, R.K., Kaczmarek, L. Neurosci. Lett. (1995) [Pubmed]
  5. A 220 kDa polypeptide, immunolocalized to epithelial tight junctions, is associated with brain clathrin preparations. Enrich, C., Jones, G.R., Bordas, J., Evans, W.H. Eur. J. Cell Biol. (1989) [Pubmed]
  6. Clathrin is required for the function of the mitotic spindle. Royle, S.J., Bright, N.A., Lagnado, L. Nature (2005) [Pubmed]
  7. Evidence for the interaction of alpha-actinin and calmodulin with the clathrin heavy chain. Merisko, E.M. Eur. J. Cell Biol. (1985) [Pubmed]
  8. Possible involvement of clathrin in neuritogenesis induced by a protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12 cells. Saito, Y., Tsubuki, S., Ito, H., Ohmi-Imajo, S., Kawashima, S. J. Biochem. (1992) [Pubmed]
  9. Clathrin heavy chain: molecular cloning and complete primary structure. Kirchhausen, T., Harrison, S.C., Chow, E.P., Mattaliano, R.J., Ramachandran, K.L., Smart, J., Brosius, J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  10. A monoclonal antibody to the heavy chain of clathrin. Louvard, D., Morris, C., Warren, G., Stanley, K., Winkler, F., Reggio, H. EMBO J. (1983) [Pubmed]
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