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Gene Review

Cadm1  -  cell adhesion molecule 1

Mus musculus

Synonyms: 2900073G06Rik, 3100001I08Rik, AI987920, Bl2, Cell adhesion molecule 1, ...
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High impact information on Cadm1

  • Expression profiling of the testes revealed that Tslc1 null mice showed increases in the expression levels of genes involved in apoptosis, adhesion, and the cytoskeleton [1].
  • In adult mice, Tslc1 null round spermatids showed evidence of normal differentiation (an acrosomal cap and F-actin polarization indistinguishable from that of wild-type spermatids); however, the surviving spermatozoa were immature, malformed, found at very low levels in the epididymis, and rarely motile [1].
  • Analysis of the first wave of spermatogenesis in Tslc1 null mice showed a delay in maturation by day 22 and degeneration of round spermatids by day 28 [1].
  • In the Tslc1(+/+) mice, TSLC1/IGSF4 expression was observed in the spermatogenic cells from the intermediate spermatogonia to the early pachytene spermatocytes and from spermatids at step 7 or later [2].
  • In 11-week-old adult Tslc1(-/-) mice, the weight of a testis was 88% that in Tslc1(+/+) mice, and the number of sperm in the semen was approximately 0.01% that in Tslc1(+/+) mice [2].

Biological context of Cadm1

  • We propose that Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system [3].
  • Transfection of B6(tg/tg) CMCs with normal MITF cDNA elevated their SgIGSF expression to normal levels [4].
  • From a cDNA library of B6(+/+) CMCs, we subtracted messenger RNAs expressed by B6(mi/mi) CMCs and found a clone encoding SgIGSF, a recently identified member of the immunoglobulin superfamily [4].
  • Because synaptic cell adhesion molecule (SynCAM), alternatively named spermatogenic Ig superfamily (SgIGSF), is expressed on both nerves and mast cells and because it binds homophilically, this molecule may be a candidate [5].
  • The Tslc1 cDNA contains a single open reading frame of 1335 bp encoding a putative protein of 445 amino acids, and its expression was detected in all tissues examined [6].

Anatomical context of Cadm1


Associations of Cadm1 with chemical compounds

  • When the nerves were specifically activated by scorpion venom, one-quarter of the attached IC-2 cells mobilized Ca(2+) after a few dozen seconds, and ectopic SgIGSF/SynCAM doubled this proportion [5].

Other interactions of Cadm1


Analytical, diagnostic and therapeutic context of Cadm1


  1. Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. van der Weyden, L., Arends, M.J., Chausiaux, O.E., Ellis, P.J., Lange, U.C., Surani, M.A., Affara, N., Murakami, Y., Adams, D.J., Bradley, A. Mol. Cell. Biol. (2006) [Pubmed]
  2. Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Yamada, D., Yoshida, M., Williams, Y.N., Fukami, T., Kikuchi, S., Masuda, M., Maruyama, T., Ohta, T., Nakae, D., Maekawa, A., Kitamura, T., Murakami, Y. Mol. Cell. Biol. (2006) [Pubmed]
  3. Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule. Galibert, L., Diemer, G.S., Liu, Z., Johnson, R.S., Smith, J.L., Walzer, T., Comeau, M.R., Rauch, C.T., Wolfson, M.F., Sorensen, R.A., Van der Vuurst de Vries, A.R., Branstetter, D.G., Koelling, R.M., Scholler, J., Fanslow, W.C., Baum, P.R., Derry, J.M., Yan, W. J. Biol. Chem. (2005) [Pubmed]
  4. SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Ito, A., Jippo, T., Wakayama, T., Morii, E., Koma, Y., Onda, H., Nojima, H., Iseki, S., Kitamura, Y. Blood (2003) [Pubmed]
  5. The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. Furuno, T., Ito, A., Koma, Y., Watabe, K., Yokozaki, H., Bienenstock, J., Nakanishi, M., Kitamura, Y. J. Immunol. (2005) [Pubmed]
  6. Identification of the Tslc1 gene, a mouse orthologue of the human tumor suppressor TSLC1 gene. Fukami, T., Satoh, H., Fujita, E., Maruyama, T., Fukuhara, H., Kuramochi, M., Takamoto, S., Momoi, T., Murakami, Y. Gene (2002) [Pubmed]
  7. Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. Shingai, T., Ikeda, W., Kakunaga, S., Morimoto, K., Takekuni, K., Itoh, S., Satoh, K., Takeuchi, M., Imai, T., Monden, M., Takai, Y. J. Biol. Chem. (2003) [Pubmed]
  8. Cloning of a soluble isoform of the SgIGSF adhesion molecule that binds the extracellular domain of the membrane-bound isoform. Koma, Y., Ito, A., Wakayama, T., Watabe, K., Okada, M., Tsubota, N., Iseki, S., Kitamura, Y. Oncogene (2004) [Pubmed]
  9. Cloning and characterization of a novel mouse immunoglobulin superfamily gene expressed in early spermatogenic cells. Wakayama, T., Ohashi, K., Mizuno, K., Iseki, S. Mol. Reprod. Dev. (2001) [Pubmed]
  10. The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. Boles, K.S., Barchet, W., Diacovo, T., Cella, M., Colonna, M. Blood (2005) [Pubmed]
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