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Gene Review

Becn1  -  beclin 1, autophagy related

Mus musculus

Synonyms: 4921513J16Rik, 5430417M23Rik, Atg6, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein
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Disease relevance of Becn1

  • Here we show that heterozygous disruption of beclin 1 increases the frequency of spontaneous malignancies and accelerates the development of hepatitis B virus-induced premalignant lesions [1].
  • The beclin 1 autophagy gene is monoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer [1].
  • The brains of mice infected with SIN/beclin had fewer Sindbis virus RNA-positive cells, fewer apoptotic cells, and lower viral titers than the brains of mice infected with SIN/beclinDeltaBcl-2BD or SIN/beclinstop [2].
  • Closed head injury induces upregulation of Beclin 1 at the cortical site of injury [3].
  • These findings show that Beclin 1 may play a role in brain responses to head trauma [3].

High impact information on Becn1


Biological context of Becn1


Anatomical context of Becn1


Physical interactions of Becn1

  • MyD88 and Trif co-immunoprecipitate with Beclin 1, a key factor in autophagosome formation [9].

Regulatory relationships of Becn1


Other interactions of Becn1


Analytical, diagnostic and therapeutic context of Becn1

  • Double staining of Beclin 1 and TUNEL indicate that most of the injured cells that exhibit double staining are neurons and not astrocytes [3].
  • Induction of autophagy and cardiac injury during the reperfusion phase was significantly attenuated in beclin 1(+/-) mice [11].


  1. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.L., Mizushima, N., Ohsumi, Y., Cattoretti, G., Levine, B. J. Clin. Invest. (2003) [Pubmed]
  2. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. Liang, X.H., Kleeman, L.K., Jiang, H.H., Gordon, G., Goldman, J.E., Berry, G., Herman, B., Levine, B. J. Virol. (1998) [Pubmed]
  3. Closed head injury induces upregulation of Beclin 1 at the cortical site of injury. Diskin, T., Tal-Or, P., Erlich, S., Mizrachy, L., Alexandrovich, A., Shohami, E., Pinkas-Kramarski, R. J. Neurotrauma (2005) [Pubmed]
  4. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X.H., Mizushima, N., Packer, M., Schneider, M.D., Levine, B. Cell (2005) [Pubmed]
  5. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Gutierrez, M.G., Master, S.S., Singh, S.B., Taylor, G.A., Colombo, M.I., Deretic, V. Cell (2004) [Pubmed]
  6. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Yue, Z., Jin, S., Yang, C., Levine, A.J., Heintz, N. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death. Li, C., Capan, E., Zhao, Y., Zhao, J., Stolz, D., Watkins, S.C., Jin, S., Lu, B. J. Immunol. (2006) [Pubmed]
  8. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B., Yuan, J. J. Biol. Chem. (2006) [Pubmed]
  9. MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. Shi, C.S., Kehrl, J.H. J. Biol. Chem. (2008) [Pubmed]
  10. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Yu, L., Alva, A., Su, H., Dutt, P., Freundt, E., Welsh, S., Baehrecke, E.H., Lenardo, M.J. Science (2004) [Pubmed]
  11. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., Sadoshima, J. Circ. Res. (2007) [Pubmed]
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