Gene Review:
HESX1 - HESX homeobox 1
Homo sapiens
Synonyms:
ANF, CPHD5, HANF, Homeobox expressed in ES cells 1, Homeobox protein ANF, ...
Wajnrajch,
Knoepfelmacher,
Haley,
Monti,
Asteria,
Yu,
Dattani,
Cameron,
Cohen,
Robinson,
Mantovani,
Beddington,
Arnhold,
Hurst,
Martinez-Barbera,
Dattani,
Carvalho,
Peverelli,
Forrest,
Hindmarsh,
Bosari,
Gupta,
Marui,
Warner,
Wales,
Stewart,
Robinson,
Radovick,
Vatti,
Dunger,
Orrico,
Woods,
Melo,
Thomas,
Alberti,
Tyrell,
Brown,
Hurley,
Leite,
Phelps,
Jurkiewicz,
Beddington,
Thomas,
Spada,
Brickman,
Pellegrini,
Mendrick,
Sagar,
Brickman,
Mendon??a,
Dattani,
Zappella,
McNay,
Woods,
Botero,
Brickman,
Beddington,
McNay,
Parks,
Zacharin,
Cohen,
Galli,
Stanhope,
Hayek,
Warne,
Beck-Peccoz,
Venturi,
Bondioni,
Clements,
Mookadam,
- Heritable disorders of pituitary development. Parks, J.S., Brown, M.R., Hurley, D.L., Phelps, C.J., Wajnrajch, M.P. J. Clin. Endocrinol. Metab. (1999)
- Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. Cohen, R.N., Cohen, L.E., Botero, D., Yu, C., Sagar, A., Jurkiewicz, M., Radovick, S. J. Clin. Endocrinol. Metab. (2003)
- Molecular effects of novel mutations in Hesx1/HESX1 associated with human pituitary disorders. Brickman, J.M., Clements, M., Tyrell, R., McNay, D., Woods, K., Warner, J., Stewart, A., Beddington, R.S., Dattani, M. Development (2001)
- HESX1 expression in human normal pituitaries and pituitary adenomas. Mantovani, G., Asteria, C., Pellegrini, C., Bosari, S., Alberti, L., Bondioni, S., Peverelli, E., Spada, A., Beck-Peccoz, P. Mol. Cell. Endocrinol. (2006)
- Alu-element insertion in the homeodomain of HESX1 and aplasia of the anterior pituitary. Sobrier, M.L., Netchine, I., Heinrichs, C., Thibaud, N., Vié-Luton, M.P., Van Vliet, G., Amselem, S. Hum. Mutat. (2005)
- HESX1 mutations are an uncommon cause of septooptic dysplasia and hypopituitarism. McNay, D.E., Turton, J.P., Kelberman, D., Woods, K.S., Brauner, R., Papadimitriou, A., Keller, E., Keller, A., Haufs, N., Krude, H., Shalet, S.M., Dattani, M.T. J. Clin. Endocrinol. Metab. (2007)
- Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Dattani, M.T., Martinez-Barbera, J.P., Thomas, P.Q., Brickman, J.M., Gupta, R., Mårtensson, I.L., Toresson, H., Fox, M., Wales, J.K., Hindmarsh, P.C., Krauss, S., Beddington, R.S., Robinson, I.C. Nat. Genet. (1998)
- A homozygous mutation in HESX1 is associated with evolving hypopituitarism due to impaired repressor-corepressor interaction. Carvalho, L.R., Woods, K.S., Mendonca, B.B., Marcal, N., Zamparini, A.L., Stifani, S., Brickman, J.M., Arnhold, I.J., Dattani, M.T. J. Clin. Invest. (2003)
- Mutation analysis of POUF-1, PROP-1 and HESX-1 show low frequency of mutations in children with sporadic forms of combined pituitary hormone deficiency and septo-optic dysplasia. Rainbow, L.A., Rees, S.A., Shaikh, M.G., Shaw, N.J., Cole, T., Barrett, T.G., Kirk, J.M. Clin. Endocrinol. (Oxf) (2005)
- Sporadic heterozygous frameshift mutation of HESX1 causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese patient. Tajima, T., Hattorri, T., Nakajima, T., Okuhara, K., Sato, K., Abe, S., Nakae, J., Fujieda, K. J. Clin. Endocrinol. Metab. (2003)
- Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia. Thomas, P.Q., Dattani, M.T., Brickman, J.M., McNay, D., Warne, G., Zacharin, M., Cameron, F., Hurst, J., Woods, K., Dunger, D., Stanhope, R., Forrest, S., Robinson, I.C., Beddington, R.S. Hum. Mol. Genet. (2001)
- Molecular genetics of septo-optic dysplasia. Dattani, M.L., Martinez-Barbera, J., Thomas, P.Q., Brickman, J.M., Gupta, R., Wales, J.K., Hindmarsh, P.C., Beddington, R.S., Robinson, I.C. Horm. Res. (2000)
- Septo-optic dysplasia with digital anomalies associated with maternal multidrug abuse during pregnancy. Orrico, A., Galli, L., Zappella, M., Monti, L., Vatti, G.P., Venturi, C., Hayek, G. Eur. J. Neurol. (2002)
- Comparison of external radiation therapy vs radical prostatectomy in lymph node positive prostate cancer patients. Kuefer, R., Volkmer, B.G., Loeffler, M., Shen, R.L., Kempf, L., Merseburger, A.S., Gschwend, J.E., Hautmann, R.E., Sandler, H.M., Rubin, M.A. Prostate Cancer Prostatic Dis. (2004)
- Rare cause of right heart failure: contained rupture of a sinus of Valsalva aneurysm associated intraventricular septal aneurysm. Mookadam, F., Haley, J., Mendrick, E. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology. (2005)
- Scanning electron microscopy of surface irregularities and thrombogenesis of polyurethane and polyethylene coronary catheters. Bourassa, M.G., Cantin, M., Sandborn, E.B., Pederson, E. Circulation (1976)
- Assessment of relative tumor burden in patients with clinical T1c prostate cancer treated with either external beam or radical prostatectomy. Hintz, B.L., Murphy, J.S., Kaswick, J.A., Bellman, G.C., Ruel, C.J., Kagan, A.R. Am. J. Clin. Oncol. (1999)
- Adrenocorticotrope deficiency with clinical evidence for late onset in combined pituitary hormone deficiency caused by a homozygous 301-302delAG mutation of the PROP1 gene. Lamesch, C., Neumann, S., Pfäffle, R., Kiess, W., Paschke, R. Pituitary (2002)
- Autosomal-dominant isolated growth hormone deficiency (IGHD type II) with normal GH-1 gene. Fintini, D., Salvatori, R., Salemi, S., Otten, B., Ubertini, G., Cambiaso, P., Mullis, P.E. Horm. Res. (2006)
- Hormonal, pituitary magnetic resonance, LHX4 and HESX1 evaluation in patients with hypopituitarism and ectopic posterior pituitary lobe. Melo, M.E., Marui, S., Carvalho, L.R., Arnhold, I.J., Leite, C.C., Mendon??a, B.B., Knoepfelmacher, M. Clin. Endocrinol. (Oxf) (2007)
- Molecular staging of surgical margins after radical prostatectomy by detection of telomerase activity. Straub, B., Müller, M., Krause, H., Goessl, C., Schrader, M., Heicappell, R., Miller, K. Prostate (2001)
- Quantitative real-time rt-PCR for detection of circulating prostate-specific antigen mRNA using sequence-specific oligonucleotide hybridization probes in prostate cancer patients. Straub, B., Müller, M., Krause, H., Schrader, M., Miller, K. Oncology (2003)
- The impact of R53C mutation on the three-dimensional structure, stability, and DNA-binding properties of the human Hesx-1 homeodomain. de la Mata, I., Garcia, J.L., González, C., Menéndez, M., Cañada, J., Jiménez-Barbero, J., Asensio, J.L. Chembiochem (2002)