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Gene Review

PSMB10  -  proteasome (prosome, macropain) subunit,...

Homo sapiens

Synonyms: LMP10, Low molecular mass protein 10, MECL1, MGC1665, Macropain subunit MECl-1, ...
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Disease relevance of PSMB10

  • Infection with lymphocytic choriomeningitis virus (LCMV) elicited a markedly reduced cytotoxic T cell (CTL) response to the LCMV epitopes GP276-286/Db and NP205-212/Kb in MECL-1-/- mice [1].
  • Invasion by Salmonella typhimurium induces increased expression of the LMP, MECL, and PA28 proteasome genes and changes in the peptide repertoire of HLA-B27 [2].
  • However, LMP-10 showed a significant selective downmodulation in the metastases as well [3].

High impact information on PSMB10

  • A subset of the proteasome beta-subunits (LMP2, LMP7, and MECL-1) and one of the accessory complexes, PA28, are upregulated by gamma-interferon and affect the generation of peptides to promote more efficient antigen recognition [4].
  • When processed from their precursors, three pairs of the 10 homologous, but distinct, beta-type subunits of eukaryotic proteasomes, that is, X/LMP7, Y/LMP2, and Z/MECL1, have an NH2-terminal threonine residue, assumed to be part of a catalytic center [5].
  • Molecular cloning of a cDNA encoding one subunit designated as Z, downregulated by IFN-gamma, showed that it is a novel proteasomal subunit with high homology to MECL1, which is markedly induced by IFN-gamma [5].
  • LMP2 is required for MECL-1 incorporation at the level of proteasome precursor formation that guarantees the concerted incorporation of two IFN-gamma-inducible proteasome subunits encoded inside and outside the MHC [6].
  • Combined deficiencies of these gene products were common, and marked deficiency of LMP10 was found in five of the nine cell lines with deficits [7].

Biological context of PSMB10


Anatomical context of PSMB10


Associations of PSMB10 with chemical compounds


Regulatory relationships of PSMB10


Other interactions of PSMB10

  • Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit [15].
  • During an immune response to pathogens, the proinflammatory cytokine interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha are released, which induce the proteasome subunits LMP2, LMP7, and MECL-1 [16].
  • No association with vitiligo was found for the MECL1 gene, which encodes a third immunoproteasome subunit and is unlinked to the MHC class II region [17].
  • The human MECL1 promoter contains two interferon-stimulated response elements (ISREs), generally known to bind members of the interferon regulatory factor (IRF) family [13].

Analytical, diagnostic and therapeutic context of PSMB10

  • Immunoprecipitation of proteasomes and analysis on two-dimensional gels revealed that during maturation the inducible proteasome subunits LMP2, LMP7, and MECL-1 are up-regulated and that the neosynthesis of proteasomes is switched exclusively to the production of immunoproteasomes containing these subunits [18].
  • The relative expression of six proteosome subunits (existing subunits X, Y, and Z and immunoproteosome subunits LMP7, LMP2, and MECL1) in 54 RCCs was investigated using RT-PCR analysis and was compared with clinicopathological measures, including patient outcome [19].


  1. An altered T cell repertoire in MECL-1-deficient mice. Basler, M., Moebius, J., Elenich, L., Groettrup, M., Monaco, J.J. J. Immunol. (2006) [Pubmed]
  2. Invasion by Salmonella typhimurium induces increased expression of the LMP, MECL, and PA28 proteasome genes and changes in the peptide repertoire of HLA-B27. Maksymowych, W.P., Ikawa, T., Yamaguchi, A., Ikeda, M., McDonald, D., Laouar, L., Lahesmaa, R., Tamura, N., Khuong, A., Yu, D.T., Kane, K.P. Infect. Immun. (1998) [Pubmed]
  3. Expression of HLA class I antigen and proteasome subunits LMP-2 and LMP-10 in primary vs. metastatic breast carcinoma lesions. Gobbi, G., Mirandola, P., Micheloni, C., Solenghi, E., Sponzilli, I., Artico, M., Soda, G., Zanelli, G., Pelusi, G., Fiorini, T., Cocco, L., Vitale, M. Int. J. Oncol. (2004) [Pubmed]
  4. Mechanisms of MHC class I--restricted antigen processing. Pamer, E., Cresswell, P. Annu. Rev. Immunol. (1998) [Pubmed]
  5. Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. Hisamatsu, H., Shimbara, N., Saito, Y., Kristensen, P., Hendil, K.B., Fujiwara, T., Takahashi, E., Tanahashi, N., Tamura, T., Ichihara, A., Tanaka, K. J. Exp. Med. (1996) [Pubmed]
  6. The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome. Groettrup, M., Standera, S., Stohwasser, R., Kloetzel, P.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Down-regulation of the transporter for antigen presentation, proteasome subunits, and class I major histocompatibility complex in tumor cell lines. Johnsen, A., France, J., Sy, M.S., Harding, C.V. Cancer Res. (1998) [Pubmed]
  8. DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene. Cruz, M., Elenich, L.A., Smolarek, T.A., Menon, A.G., Monaco, J.J. Genomics (1997) [Pubmed]
  9. Genomic organization, localization and polymorphism of porcine PSMB10, a gene encoding the third beta-type proteasome subunit of 26S proteasome complex. Wu, X., Yang, S.L., Yerle, M., Zhu, Z.M., Wang, H.L., Wang, H., Li, K. J. Anim. Breed. Genet. (2006) [Pubmed]
  10. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Meng, L., Mohan, R., Kwok, B.H., Elofsson, M., Sin, N., Crews, C.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. Phenotype-dependent differences in proteasome subunit composition and cleavage specificity in B cell lines. Frisan, T., Levitsky, V., Polack, A., Masucci, M.G. J. Immunol. (1998) [Pubmed]
  12. Constitutive and interferon-gamma-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 1. Foss, G.S., Larsen, F., Solheim, J., Prydz, H. Biochim. Biophys. Acta (1998) [Pubmed]
  13. Interferon regulatory factor 1 mediates the interferon-gamma induction of the human immunoproteasome subunit multicatalytic endopeptidase complex-like 1. Foss, G.S., Prydz, H. J. Biol. Chem. (1999) [Pubmed]
  14. Modified flow cytometry and cell-ELISA methodology to detect HLA class I antigen processing machinery components in cytoplasm and endoplasmic reticulum. Ogino, T., Wang, X., Ferrone, S. J. Immunol. Methods (2003) [Pubmed]
  15. Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit. Nandi, D., Jiang, H., Monaco, J.J. J. Immunol. (1996) [Pubmed]
  16. Structural plasticity of the proteasome and its function in antigen processing. Groettrup, M., van den Broek, M., Schwarz, K., Macagno, A., Khan, S., de Giuli, R., Schmidtke, G. Crit. Rev. Immunol. (2001) [Pubmed]
  17. Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo. Casp, C.B., She, J.X., McCormack, W.T. Genes Immun. (2003) [Pubmed]
  18. Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation. Macagno, A., Gilliet, M., Sallusto, F., Lanzavecchia, A., Nestle, F.O., Groettrup, M. Eur. J. Immunol. (1999) [Pubmed]
  19. Prognostic significance of immuno-proteosome subunit expression in patients with renal-cell carcinoma: a preliminary study. Murakami, Y., Kanda, K., Yokota, K., Kanayama, H., Kagawa, S. Molecular urology. (2001) [Pubmed]
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