Chemical Compound Review:
AC1NRAZ8 (2S,3S)-2-[[(2S,3S)-2- (ethanoyl-methyl...
Synonyms:
SMP2_000342, EPX
Kikuchi,
Shinpo,
Tsuji,
Takeuchi,
Yamagishi,
Makita,
Niino,
Yabe,
Tashiro,
Nencioni,
Wille,
Dal Bello,
Boy,
Cirmena,
Wesselborg,
Belka,
Brossart,
Patrone,
Ballestrero,
Garrett,
Chen,
Gutierrez,
Zhao,
Escobedo,
Rossini,
Harris,
Gallwitz,
Kim,
Hu,
Crews,
Mundy,
Kwiatkowska,
Wojtczak,
Popłońska,
Teodorczyk,
Schaefer,
Takahashi,
Morales,
Harris,
Barton,
Osawa,
Nakajima,
Saubermann,
Slupianek,
Skorski,
Ohkawa,
Asakura,
Aoki,
Shibata,
Minami,
Fujiwara,
Sai,
Marushima,
Kuzuu,
Kato,
Kutsuna,
Oshitani,
Kitagawa,
Kikuchi,
Shinpo,
Takeuchi,
Tsuji,
Yabe,
Niino,
Tashiro,
Yang,
O'Neill,
Jin,
Foty,
Medina,
Xu,
Lomas,
Arndt,
Tang,
Nakada,
Yan,
Hait,
- Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Meng, L., Mohan, R., Kwok, B.H., Elofsson, M., Sin, N., Crews, C.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses. Schwarz, K., de Giuli, R., Schmidtke, G., Kostka, S., van den Broek, M., Kim, K.B., Crews, C.M., Kraft, R., Groettrup, M. J. Immunol. (2000)
- Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons. Kikuchi, S., Shinpo, K., Tsuji, S., Takeuchi, M., Yamagishi, S., Makita, Z., Niino, M., Yabe, I., Tashiro, K. Brain Res. (2003)
- Establishment and some characteristics of epoxomicin (a proteasome inhibitor) resistant variants of the human squamous cell carcinoma cell line, A431. Ohkawa, K., Asakura, T., Aoki, K., Shibata, S., Minami, J., Fujiwara, C., Sai, T., Marushima, H., Kuzuu, H. Int. J. Oncol. (2004)
- Epoxomicin, a new antitumor agent of microbial origin. Hanada, M., Sugawara, K., Kaneta, K., Toda, S., Nishiyama, Y., Tomita, K., Yamamoto, H., Konishi, M., Oki, T. J. Antibiot. (1992)
- Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. Garrett, I.R., Chen, D., Gutierrez, G., Zhao, M., Escobedo, A., Rossini, G., Harris, S.E., Gallwitz, W., Kim, K.B., Hu, S., Crews, C.M., Mundy, G.R. J. Clin. Invest. (2003)
- Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Darios, F., Corti, O., Lücking, C.B., Hampe, C., Muriel, M.P., Abbas, N., Gu, W.J., Hirsch, E.C., Rooney, T., Ruberg, M., Brice, A. Hum. Mol. Genet. (2003)
- Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. Yang, J.M., O'Neill, P., Jin, W., Foty, R., Medina, D.J., Xu, Z., Lomas, M., Arndt, G.M., Tang, Y., Nakada, M., Yan, L., Hait, W.N. J. Biol. Chem. (2006)
- PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells. Schaefer, K.L., Takahashi, H., Morales, V.M., Harris, G., Barton, S., Osawa, E., Nakajima, A., Saubermann, L.J. Int. J. Cancer (2007)
- NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner. Slupianek, A., Skorski, T. Exp. Hematol. (2004)
- Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures. Chondrogianni, N., Gonos, E.S. Biogerontology. (2004)
- The influence of epoxomicin, inhibitor of proteasomal proteolytic activity, on spermiogenesis in Chara vulgaris. Kwiatkowska, M., Wojtczak, A., Popłońska, K., Teodorczyk, M. Folia Histochem. Cytobiol. (2003)
- Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons. Roucou, X., Guo, Q., Zhang, Y., Goodyer, C.G., LeBlanc, A.C. J. Biol. Chem. (2003)
- Cooperative cytotoxicity of proteasome inhibitors and tumor necrosis factor-related apoptosis-inducing ligand in chemoresistant Bcl-2-overexpressing cells. Nencioni, A., Wille, L., Dal Bello, G., Boy, D., Cirmena, G., Wesselborg, S., Belka, C., Brossart, P., Patrone, F., Ballestrero, A. Clin. Cancer Res. (2005)
- Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons. Kikuchi, S., Shinpo, K., Takeuchi, M., Tsuji, S., Yabe, I., Niino, M., Tashiro, K. J. Neurosci. Res. (2002)
- Cyclic AMP delays neutrophil apoptosis via stabilization of Mcl-1. Kato, T., Kutsuna, H., Oshitani, N., Kitagawa, S. FEBS Lett. (2006)
- Major histocompatibility complex class I restricted T-cell autoreactivity in human peripheral blood mononuclear cells. Eleftheriadis, T., Voyatzi, S., Antoniadi, G., Kartsios, C., Liakopoulos, V., Paraskevopoulos, P., Galaktidou, G. Cell. Immunol. (2006)
- Roles of the ubiquitin/proteasome pathway in pollen tube growth with emphasis on MG132-induced alterations in ultrastructure, cytoskeleton, and cell wall components. Sheng, X., Hu, Z., Lü, H., Wang, X., Baluska, F., Samaj, J., Lin, J. Plant Physiol. (2006)
- CXCR4/CCR5 down-modulation and chemotaxis are regulated by the proteasome pathway. Fernandis, A.Z., Cherla, R.P., Chernock, R.D., Ganju, R.K. J. Biol. Chem. (2002)
- Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization. Landsman, T., Waxman, D.J. J. Biol. Chem. (2005)
- Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling. Naiki, Y., Michelsen, K.S., Zhang, W., Chen, S., Doherty, T.M., Arditi, M. J. Biol. Chem. (2005)
- HIV-1 reverse transcriptase targeted for proteasomal degradation as a prototype vaccine against drug-resistant HIV-1. Starodubova, E., Boberg, A., Kashuba, E.V., Wahren, B., Karpov, V., Isaguliants, M. Vaccine (2006)