The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FGF2  -  fibroblast growth factor 2 (basic)

Macaca mulatta

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FGF2


High impact information on FGF2

  • For neural induction of pATSCs and non-human primate bone marrow stromal cells (pBMSCs), the cells were cultured in Neurobasal (NB) media supplemented with B27, basic fibroblast growth factor (bFGF), brain-derived neurotrophic factor (BDNF) and epidermal growth factor (EGF) [3].
  • To detect functional changes in the BMZ, we measured perlecan and fibroblast growth factor-2 (FGF-2) [4].
  • After removal of FGF-2, approximately 70% of the NPCs differentiated into neuronal phenotypes expressing either microtubule-associated protein-2C (MAP2C) or neuronal nuclear antigen (NeuN), and approximately 28% differentiated into glial cell types expressing glial fibrillary acidic protein [5].
  • To detect changes in the function of the BMZ, we measured immunoreactivity of the heparan sulfate proteoglycan, perlecan, and FGF-2 [6].
  • We conclude that basal cells and FGF-2 are involved with significant remodeling of the BMZ in the developing trachea of infant rhesus monkeys exposed to HDMA [6].

Biological context of FGF2


Anatomical context of FGF2


Analytical, diagnostic and therapeutic context of FGF2

  • We also used in situ hybridization and immunohistochemistry to investigate the expression patterns of FGF2 and FGFR1-4 at the developing fovea, and three other sample locations on the horizontal meridian [1].
  • ELISA measurements indicating the growth potency of conditioned media correlated with the amount of bFGF in the conditioned media [2].


  1. Gradients of cone differentiation and FGF expression during development of the foveal depression in macaque retina. Cornish, E.E., Madigan, M.C., Natoli, R., Hales, A., Hendrickson, A.E., Provis, J.M. Vis. Neurosci. (2005) [Pubmed]
  2. Basic fibroblast growth factor as a growth factor for SRV-2-infected simian retroperitoneal fibromatosis cells, an animal model for AIDS related Kaposi's sarcoma. Chung, C.H., Chiang, J., Jiang, C.M., Chen, Y.Y., Huang, C.Y., Chen, P.G., Chen, Y.J. Neoplasma (2001) [Pubmed]
  3. Neurogenesis of Rhesus adipose stromal cells. Kang, S.K., Putnam, L.A., Ylostalo, J., Popescu, I.R., Dufour, J., Belousov, A., Bunnell, B.A. J. Cell. Sci. (2004) [Pubmed]
  4. Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen. Evans, M.J., Fanucchi, M.V., Baker, G.L., Van Winkle, L.S., Pantle, L.M., Nishio, S.J., Schelegle, E.S., Gershwin, L.J., Miller, L.A., Hyde, D.M., Sannes, P.L., Plopper, C.G. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  5. Differentiation of monkey embryonic stem cells into neural lineages. Kuo, H.C., Pau, K.Y., Yeoman, R.R., Mitalipov, S.M., Okano, H., Wolf, D.P. Biol. Reprod. (2003) [Pubmed]
  6. Fibroblast growth factor-2 in remodeling of the developing basement membrane zone in the trachea of infant rhesus monkeys sensitized and challenged with allergen. Evans, M.J., Van Winkle, L.S., Fanucchi, M.V., Baker, G.L., Murphy, A.E., Nishio, S.J., Schelegle, E.S., Gershwin, L.J., Sannes, P.L., Plopper, C.G. Lab. Invest. (2002) [Pubmed]
  7. VEGF, bFGF and their receptors at the fetal-maternal interface of the rhesus monkey. Wei, P., Yu, F.Q., Chen, X.L., Tao, S.X., Han, C.S., Liu, Y.X. Placenta (2004) [Pubmed]
  8. Regulation of connective tissue growth factor gene expression in retinal vascular endothelial cells by angiogenic growth factors. Wunderlich, K., Senn, B.C., Todesco, L., Flammer, J., Meyer, P. Graefes Arch. Clin. Exp. Ophthalmol. (2000) [Pubmed]
  9. Primary culture of cortical neurons, type-1 astrocytes, and microglial cells from cynomolgus monkey (Macaca fascicularis) fetuses. Negishi, T., Ishii, Y., Kyuwa, S., Kuroda, Y., Yoshikawa, Y. J. Neurosci. Methods (2003) [Pubmed]
  10. Effects of chymase on the macular region in monkeys and porcine muller cells: probable involvement of chymase in the onset of idiopathic macular holes. Sugiyama, T., Katsumura, K., Nakamura, K., Kobayashi, M., Muramatsu, M., Maruichi, M., Oku, H., Takai, S., Miyazaki, M., Ikeda, T. Ophthalmic Res. (2006) [Pubmed]
WikiGenes - Universities