Disease relevance of FGF2

• There is no similar gradient of FGF2 mRNA expression in the ganglion cell layer of the same sections [1].
• Basic fibroblast growth factor (bFGF) and vascular endothelial cell growth factor (VEGF) were demonstrated to be important factors sustaining the growth of Kaposi's sarcoma [2].
• The data from flow cytometry demonstrated the co-existence of SRV-2 and bFGF among RF cells and RF tissues [2].
• Basic fibroblast growth factor as a growth factor for SRV-2-infected simian retroperitoneal fibromatosis cells, an animal model for AIDS related Kaposi's sarcoma [2].

High impact information on FGF2

• For neural induction of pATSCs and non-human primate bone marrow stromal cells (pBMSCs), the cells were cultured in Neurobasal (NB) media supplemented with B27, basic fibroblast growth factor (bFGF), brain-derived neurotrophic factor (BDNF) and epidermal growth factor (EGF) [3].
• To detect functional changes in the BMZ, we measured perlecan and fibroblast growth factor-2 (FGF-2) [4].
• After removal of FGF-2, approximately 70% of the NPCs differentiated into neuronal phenotypes expressing either microtubule-associated protein-2C (MAP2C) or neuronal nuclear antigen (NeuN), and approximately 28% differentiated into glial cell types expressing glial fibrillary acidic protein [5].
• To detect changes in the function of the BMZ, we measured immunoreactivity of the heparan sulfate proteoglycan, perlecan, and FGF-2 [6].
• We conclude that basal cells and FGF-2 are involved with significant remodeling of the BMZ in the developing trachea of infant rhesus monkeys exposed to HDMA [6].

Biological context of FGF2

• These data suggest that VEGF and bFGF may be involved in angiogenesis, cytotrophoblast proliferation and migration during early stage of placentation in the rhesus monkey [7].
• RESULTS: FCS, TGF-beta 1, TGF-beta 3, bFGF, and EGF induced an upregulation of CTGF gene expression in RVEC in a time-dependent manner [8].
• These results indicate that bFGF is an important growth factor to promote RF cell growth in vitro and RF tumor in vivo [2].

Anatomical context of FGF2

• In addition to the vascular endothelial cells and the vascular smooth muscle cells, the protein and mRNA for bFGF were also detected in cyto/syncytiotrophoblast bilayer, whereas the staining for Flg protein was mainly localized in the cytotrophoblast cells [7].
• The growth of type-1 astrocytes in the serum-free medium was stimulated by epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and hydrocortisone, which are known growth factors in rat type-1 astrocytes [9].
• Expression of c-kit, a stem cell factor receptor, and nestin was examined in porcine Muller cells cultured with basic fibroblast growth factor [10].

Analytical, diagnostic and therapeutic context of FGF2

• We also used in situ hybridization and immunohistochemistry to investigate the expression patterns of FGF2 and FGFR1-4 at the developing fovea, and three other sample locations on the horizontal meridian [1].
• ELISA measurements indicating the growth potency of conditioned media correlated with the amount of bFGF in the conditioned media [2].

References