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FGF2  -  fibroblast growth factor 2 (basic)

Canis lupus familiaris

 
 
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Disease relevance of BFGF

  • In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reduced infarct size [1].
  • CONCLUSIONS: Systemic administration of bFGF enhanced collateral conductance in dogs with progressive single-vessel coronary occlusion [2].
  • These data provide support for the clinical investigation of bFGF in selected patients with ischemic heart disease [3].
  • These data suggest that bFGF mediates myocardial salvage independently of angiogenesis and that reperfusion after infarction may attenuate the stimulus for neovascularization [4].
  • Prolonged bFGF administration was also associated with a decrease in arterial pressure, moderate thrombocytopenia, and moderate, reversible anemia [2].
 

High impact information on BFGF

 

Chemical compound and disease context of BFGF

 

Biological context of BFGF

  • The aim of the present study was to examine the effect of systemically administered bFGF on collateral blood flow and to assess its pharmacokinetics and potential side effects [2].
  • These data indicate that a 5-cm acellular nerve segment containing Schwann cell basal laminae can be used successfully as an allograft without any immunosuppressants and that exogenously applied bFGF can improve nerve regeneration by enhancing the growth of regenerating axons [9].
  • Throughout the 4 weeks, vascularization and osteogenesis were active only in the bFGF-treated group (p < 0.01) [10].
  • Cell proliferation around the fragments was active, and those cells were bFGF positive [11].
  • Heparin (10 microg/ml) accelerated both processes of bFGF-mediated lymphangiogenesis of the LEC [12].
 

Anatomical context of BFGF

 

Associations of BFGF with chemical compounds

  • Platinum coils unmodified, coated with heparin, or immobilized with heparin and bFGF were examined [16].
  • Regulation of alpha(v)beta3 and alpha5beta1 integrin receptors by basic fibroblast growth factor and platelet-derived growth factor-BB in intrasynovial flexor tendon cells [14].
  • To explore the regulatory roles of specific growth factors on integrin expression by intrasynovial flexor tendon cells, the present study assessed the in vitro effects of basic fibroblast growth factor and platelet derived growth factor-BB on expression of the alpha5beta1 and alpha(v)beta3 integrins in these cells [14].
  • METHODS: Ultrathin multiorganic layers were assembled on a platinum coil through successive deposition of cationic polyethylenimine and anionic heparin, and then bFGF was immobilized through an affinity interaction with heparin [16].
  • The IMA and SVG specimens were harvested from 12 dogs and distended at 25 or 200 mm Hg for 15 minutes, and then the bFGF receptor uptake was measured in them using iodine 125-labeled bFGF [17].
 

Other interactions of BFGF

 

Analytical, diagnostic and therapeutic context of BFGF

References

  1. Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor. Yanagisawa-Miwa, A., Uchida, Y., Nakamura, F., Tomaru, T., Kido, H., Kamijo, T., Sugimoto, T., Kaji, K., Utsuyama, M., Kurashima, C. Science (1992) [Pubmed]
  2. Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart. Lazarous, D.F., Scheinowitz, M., Shou, M., Hodge, E., Rajanayagam, S., Hunsberger, S., Robison, W.G., Stiber, J.A., Correa, R., Epstein, S.E. Circulation (1995) [Pubmed]
  3. Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. Lazarous, D.F., Shou, M., Scheinowitz, M., Hodge, E., Thirumurti, V., Kitsiou, A.N., Stiber, J.A., Lobo, A.D., Hunsberger, S., Guetta, E., Epstein, S.E., Unger, E.F. Circulation (1996) [Pubmed]
  4. Reduction in myocardial infarct size by basic fibroblast growth factor after temporary coronary occlusion in a canine model. Horrigan, M.C., MacIsaac, A.I., Nicolini, F.A., Vince, D.G., Lee, P., Ellis, S.G., Topol, E.J. Circulation (1996) [Pubmed]
  5. Mast cell tryptase is a mitogen for cultured fibroblasts. Ruoss, S.J., Hartmann, T., Caughey, G.H. J. Clin. Invest. (1991) [Pubmed]
  6. Angiogenic therapy of acute myocardial infarction by intrapericardial injection of basic fibroblast growth factor and heparin sulfate: an experimental study. Uchida, Y., Yanagisawa-Miwa, A., Nakamura, F., Yamada, K., Tomaru, T., Kimura, K., Morita, T. Am. Heart J. (1995) [Pubmed]
  7. Basic fibroblast growth factor impregnated hydrogel microspheres for embolization of cerebral arteriovenous malformations. Nishi, S., Nakayama, Y., Hashimoto, N., Matsuda, T. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1998) [Pubmed]
  8. High urine concentrations of basic fibroblast growth factor in dogs with bladder cancer. Allen, D.K., Waters, D.J., Knapp, D.W., Kuczek, T. J. Vet. Intern. Med. (1996) [Pubmed]
  9. Long acellular nerve transplants for allogeneic grafting and the effects of basic fibroblast growth factor on the growth of regenerating axons in dogs: a preliminary report. Ide, C., Tohyama, K., Tajima, K., Endoh, K., Sano, K., Tamura, M., Mizoguchi, A., Kitada, M., Morihara, T., Shirasu, M. Exp. Neurol. (1998) [Pubmed]
  10. Novel approach to regeneration of periodontal tissues based on in situ tissue engineering: effects of controlled release of basic fibroblast growth factor from a sandwich membrane. Nakahara, T., Nakamura, T., Kobayashi, E., Inoue, M., Shigeno, K., Tabata, Y., Eto, K., Shimizu, Y. Tissue engineering. (2003) [Pubmed]
  11. Endogenous basic fibroblast growth factor for endothelialization due to angiogenesis in fabric vascular prostheses. Tomizawa, Y., Noishiki, Y., Okoshi, T., Nishida, H., Endo, M., Koyanagi, H. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1996) [Pubmed]
  12. Basic fibroblast growth factor-mediated lymphangiogenesis of lymphatic endothelial cells isolated from dog thoracic ducts: effects of heparin. Tan, Y. Jpn. J. Physiol. (1998) [Pubmed]
  13. Evidence for circulating bone marrow-derived endothelial cells. Shi, Q., Rafii, S., Wu, M.H., Wijelath, E.S., Yu, C., Ishida, A., Fujita, Y., Kothari, S., Mohle, R., Sauvage, L.R., Moore, M.A., Storb, R.F., Hammond, W.P. Blood (1998) [Pubmed]
  14. Regulation of alpha(v)beta3 and alpha5beta1 integrin receptors by basic fibroblast growth factor and platelet-derived growth factor-BB in intrasynovial flexor tendon cells. Harwood, F.L., Goomer, R.S., Gelberman, R.H., Silva, M.J., Amiel, D. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (1999) [Pubmed]
  15. Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries. Iwakura, A., Tabata, Y., Koyama, T., Doi, K., Nishimura, K., Kataoka, K., Fujita, M., Komeda, M. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  16. Immobilization of basic fibroblast growth factor on a platinum microcoil to enhance tissue organization in intracranial aneurysms. Ohyama, T., Nishide, T., Iwata, H., Sato, H., Toda, M., Toma, N., Taki, W. J. Neurosurg. (2005) [Pubmed]
  17. Mammary artery versus saphenous vein grafts: assessment of basic fibroblast growth factor receptors. Nguyen, H.C., Grossi, E.A., LeBoutillier, M., Steinberg, B.M., Rifkin, D.B., Baumann, F.G., Colvin, S.B., Galloway, A.C. Ann. Thorac. Surg. (1994) [Pubmed]
  18. Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis. Lazarous, D.F., Shou, M., Stiber, J.A., Hodge, E., Thirumurti, V., Gonçalves, L., Unger, E.F. Cardiovasc. Res. (1999) [Pubmed]
  19. Cellular origin and rate of endothelial cell coverage of PTFE grafts. Bull, D.A., Hunter, G.C., Holubec, H., Aguirre, M.L., Rappaport, W.D., Putnam, C.W. J. Surg. Res. (1995) [Pubmed]
  20. Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs. Rajanayagam, M.A., Shou, M., Thirumurti, V., Lazarous, D.F., Quyyumi, A.A., Goncalves, L., Stiber, J., Epstein, S.E., Unger, E.F. J. Am. Coll. Cardiol. (2000) [Pubmed]
  21. Longitudinal changes in myocardial basic fibroblast growth factor (FGF-2) activity following coronary artery ligation in the dog. Cohen, M.V., Vernon, J., Yaghdjian, V., Hatcher, V.B. J. Mol. Cell. Cardiol. (1994) [Pubmed]
 
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