The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pfkp  -  phosphofructokinase, platelet

Rattus norvegicus

Synonyms: 6-phosphofructokinase type C, ATP-PFK, ATP-dependent 6-phosphofructokinase, platelet type, PFK-C, PFK-P, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pfkp


Biological context of Pfkp


Anatomical context of Pfkp

  • The localization of aldolase (ALD) was also shifted towards the plasma membrane (and colocalized with PFK) in CAV-1 over-expressing cells [4].
  • We conclude that CAV-1 functions as a scaffolding protein for PFK, ALD and perhaps other glycolytic enzymes, either through direct interaction or accessory proteins, thus contributing to compartmented metabolism in vascular smooth muscle [4].
  • The properties of the near-purified enzyme (specific activity 140 units/mg) were compared with those of phosphofructokinase from normal rat thyroid (specific activity 134 units/mg) [2].
  • Phosphofructokinase, glycerol phosphate dehydrogenase and glucose 6-phosphate dehydrogenase were more active in the proximal regions of the epididymis, whereas hexokinase, lactate dehydrogenase and phosphorylase were more active in the distal segment [7].
  • When liver cell homogenates were subjected to centrifugation at higher forces (37,400 X g for 60 minutes or greater), the assayable activity of phosphofructokinase in supernatant fractions began to diminish [6].

Associations of Pfkp with chemical compounds


Regulatory relationships of Pfkp


Other interactions of Pfkp

  • The PFK-C and PFK-A isozymes each comprised about half the total and only small amounts of the PFK-B isozyme were present in both regions [11].
  • 6. There is a diminished activity of glucokinase and of enzymes of the glycolytic pathway below phosphofructokinase in livers from hypothyroid rats [9].

Analytical, diagnostic and therapeutic context of Pfkp

  • Confocal immunofluorescence microscopy was used to study the distribution of phosphofructokinase (PFK) and CAV-1 in the transfected cells [4].


  1. Effects of mechanical activity and hormones on myocardial glucose and fatty acid utilization. Neely, J.R., Whitmer, M., Mochizuki, S. Circ. Res. (1976) [Pubmed]
  2. Differences in phosphofructokinase regulation in normal and tumor rat thyroid cells. Meldolesi, M.F., Macchia, V., Laccetti, P. J. Biol. Chem. (1976) [Pubmed]
  3. The stimulus-secretion coupling of glucose-induced insulin release. Fasting-induced adaptation of key glycolytic enzymes in isolated islets. Malaisse, W.J., Sener, A., Levy, J. J. Biol. Chem. (1976) [Pubmed]
  4. Overexpression of caveolin-1 results in increased plasma membrane targeting of glycolytic enzymes: the structural basis for a membrane associated metabolic compartment. Raikar, L.S., Vallejo, J., Lloyd, P.G., Hardin, C.D. J. Cell. Biochem. (2006) [Pubmed]
  5. Effects of the Na(+)/H(+) exchanger monensin on intracellular pH in astroglia. Itoh, Y., Law, M.J., Sokoloff, L. Brain Res. (2000) [Pubmed]
  6. Gluconeogenesis in isolated rat hepatic parenchymal cells. IX. Differential effects of glucagon and epinephrine on phosphofructokinase and pyruvate kinase. Veneziale, C.M., Deering, N.G., Thompson, H.J. Mayo Clin. Proc. (1976) [Pubmed]
  7. Activity and androgenic control of glycolytic enzymes in the epididymis and epididymal spermatozoa of the rat. Brooks, D.E. Biochem. J. (1976) [Pubmed]
  8. Inhibition of glycolytic enzymes of rat liver and hepatomas by free fatty acids. Lea, M.A., Weber, G., Morris, H.P. Oncology (1976) [Pubmed]
  9. Effects of thyroid hormone deficiency on the distribution of hepatic metabolites and control of pathways of carbohydrate metabolism in liver and adipose tissue of the rat. Baquer, N.Z., Cascales, M., McLean, P., Greenbaum, A.L. Eur. J. Biochem. (1976) [Pubmed]
  10. The role of the glucose-6-phosphate in the phosphorylase b kinase activation found in perfused rat hearts treated by dinitrophenol. Vercesi, A.E., Focesi, A. An. Acad. Bras. Cienc. (1976) [Pubmed]
  11. Phosphofructokinase in the rat nervous system: regional differences in activity and characteristics of axonal transport. Oblinger, M.M., Foe, L.G., Kwiatkowska, D., Kemp, R.G. J. Neurosci. Res. (1988) [Pubmed]
WikiGenes - Universities