Disease relevance of RINT1

• ZIOS, sRaw and Rint, but not Ptc,O2 and FEV1, detected the subclinical increase in bronchial muscle tone in the children during baseline, which was revealed by the significantly reduced airway obstruction after inhalation of a beta 2-agonist as compared to baseline [1].
• The magnitude of Rint increase induced by nasal cold air breathing was correlated with the sensitivity to carbachol (defined as the dose inducing a 50% increase in specific airway conductance (D50)) in asthmatic patients with symptoms of rhinitis [2].
• This effect disappeared after nose anaesthesia or after inhalation of a cholinergic antagonist. oIPPV never changed Rint, even though the associated hypocapnia was present and more accentuated than during nIPPV [3].

Psychiatry related information on RINT1

• Airways resistance measured by the interrupter technique (Rint) requires little patient cooperation and has been successfully used in young children, but little studied in infants [4].

High impact information on RINT1

• The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1 [5].
• We further show that RINT-1 is essential for telomere length control [5].
• RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex [6].
• To address the role of RINT-1 in membrane trafficking, we examined the effects of overexpression and knockdown of RINT-1 on Golgi morphology and protein transport from the ER [6].
• The conserved central and C-terminal regions of RINT-1 are required for its interaction with Rad50 [7].

Biological context of RINT1

• Human RINT-1 shares sequence homology with a novel protein identified in Drosophila melanogaster, including a coiled-coil domain within its N-terminal 150 amino acids, a conserved central domain of about 350 amino acids, and a C-terminal region of 90 amino acids exhibiting 35--38% identity [7].
• These results suggest that RINT-1 may play a role in the regulation of cell cycle control after DNA damage [7].
• This study reports the repeatability of airway resistance measurements using the interrupter technique (Rint) in children with and without respiratory symptoms [8].
• Somatosensory evoked potentials were also recorded in group RCONT and RINT [9].
• After nasal anesthesia or inhalation of a cholinergic antagonist, cold air did not induce a change in Rint [10].

Anatomical context of RINT1

• METHODS: Interrupter resistance (Rint), additional tissue viscoelastic resistance (deltaR), and quasi-static elastance (Est) of lung (L) and chest wall were assessed by means of the rapid end-inspiratory occlusion method in two groups of seven healthy paralyzed subjects anesthetized with diazepam or isoflurane [11].
• The changes in interrupter resistances (Rint) in response to nIPPV were tested before and after local anaesthesia of the nasal mucosa in normal subjects [3].
• Reff has two components - a true resistance (Rint) and a virtual one (Rfv) related to the force-velocity characteristic of the respiratory muscles [12].

Associations of RINT1 with chemical compounds

• Baseline lung function was significantly decreased in asthmatic children as compared with healthy control subjects as reflected by all techniques used in the study. sRaw, Rint, and Rrs5, but not Xrs5, improved significantly with terbutaline as compared with placebo in healthy control subjects [13].
• On the same occasion, three Rint measurements were made 15 minutes apart, before and after placebo and salbutamol given in random order [8].
• Twenty other rabbits received either repeated injections of 0.2 ml of 0.2% ropivacaine every 2 days during 2 weeks (total dose of 2.8 mg; group RINT); or a continuous intrathecal infusion of 0.2% ropivacaine at the rate of 1.8 ml/h over 45 min (2.7 mg; group RCONT) [9].
• The order of sensitivity of the techniques to assess methacholine-induced changes in lung function was ZIOS > sRaw > Ptc,O2 > FEV1 > Rint [1].
• On three separate occasions, a 100 +/- 5% increase in baseline Rint was induced by MCh inhalation [14].

Other interactions of RINT1

• In contrast, no redistribution or release of RINT-1 from the syntaxin 18 complex was observed when ZW10 expression was reduced [6].

Analytical, diagnostic and therapeutic context of RINT1

• We designed a multicenter study using a standardized procedure for Rint measurements [15].
• Static and dynamic airway pressures, minimum (Rint) and maximum (Rrs) inspiratory resistance, the difference between Rrs and Rint (delta R), static end-inspiratory respiratory system compliance (Cst,rs), intrinsic positive end-expiratory pressure (PEEPi) and heart rate (HR) were measured before and at 15, 30 and 60 min after S [16].
• They were compared to the Rint changes induced by oral intermittent positive-pressure ventilation (oIPPV) in the same individuals [3].
• Lung function was measured in 110 children with a mean+/-SD age of 3.8+/-1.0 yrs using the interruptor technique (resistance assessed using the interruptor technique (Rint)), whole body plethysmography (specific airway resistance (sRaw) and respiratory resistance (Rrs,5)and reactance at 5 Hz (Xrs,5) using the impulse oscillation technique [17].
• Considering that only minimal comprehension and coordination are needed without forced breathing technique, the Rint measurement can provide a useful alternative for assessment of EIB in children unable to perform reliable spirometry [18].

References