Gene Review:
RBL2 - retinoblastoma-like 2
Homo sapiens
Synonyms:
130 kDa retinoblastoma-associated protein, P130, RB2, RBR-2, Rb2, ...
- Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer. Modi, S., Kubo, A., Oie, H., Coxon, A.B., Rehmatulla, A., Kaye, F.J. Oncogene (2000)
- E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Sardet, C., Vidal, M., Cobrinik, D., Geng, Y., Onufryk, C., Chen, A., Weinberg, R.A. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Inducible pRb2/p130 expression and growth-suppressive mechanisms: evidence of a pRb2/p130, p27Kip1, and cyclin E negative feedback regulatory loop. Howard, C.M., Claudio, P.P., De Luca, A., Stiegler, P., Jori, F.P., Safdar, N.M., Caputi, M., Khalili, K., Giordano, A. Cancer Res. (2000)
- Genetic alterations of the retinoblastoma-related gene RB2/p130 identify different pathogenetic mechanisms in and among Burkitt's lymphoma subtypes. Cinti, C., Leoncini, L., Nyongo, A., Ferrari, F., Lazzi, S., Bellan, C., Vatti, R., Zamparelli, A., Cevenini, G., Tosi, G.M., Claudio, P.P., Maraldi, N.M., Tosi, P., Giordano, A. Am. J. Pathol. (2000)
- Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid. Zerr, I., Bodemer, M., Otto, M., Poser, S., Windl, O., Kretzschmar, H.A., Gefeller, O., Weber, T. Lancet (1996)
- The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas. De Luca, A., Baldi, A., Esposito, V., Howard, C.M., Bagella, L., Rizzo, P., Caputi, M., Pass, H.I., Giordano, G.G., Baldi, F., Carbone, M., Giordano, A. Nat. Med. (1997)
- The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). Tedesco, D., Lukas, J., Reed, S.I. Genes Dev. (2002)
- Protein phosphatase 2A associates with Rb2/p130 and mediates retinoic acid-induced growth suppression of ovarian carcinoma cells. Vuocolo, S., Purev, E., Zhang, D., Bartek, J., Hansen, K., Soprano, D.R., Soprano, K.J. J. Biol. Chem. (2003)
- pRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol. Tonini, T., Gabellini, C., Bagella, L., D'Andrilli, G., Masciullo, V., Romano, G., Scambia, G., Zupi, G., Giordano, A. Clin. Cancer Res. (2004)
- Loss of pRb2/p130 expression is associated with unfavorable clinical outcome in lung cancer. Caputi, M., Groeger, A.M., Esposito, V., De Luca, A., Masciullo, V., Mancini, A., Baldi, F., Wolner, E., Giordano, A. Clin. Cancer Res. (2002)
- Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells. Xu, X., Kang, S.H., Heidenreich, O., Okerholm, M., O'Shea, J.J., Nerenberg, M.I. J. Clin. Invest. (1995)
- CrkI adapter protein modulates cell migration and invasion in glioblastoma. Takino, T., Nakada, M., Miyamori, H., Yamashita, J., Yamada, K.M., Sato, H. Cancer Res. (2003)
- Molecular heterogeneity at the breakpoints of smaller 20q deletions. Hollings, P.E. Genes Chromosomes Cancer (1994)
- Glycogen synthase kinase 3 phosphorylates RBL2/p130 during quiescence. Litovchick, L., Chestukhin, A., DeCaprio, J.A. Mol. Cell. Biol. (2004)
- E2F-5, a new E2F family member that interacts with p130 in vivo. Hijmans, E.M., Voorhoeve, P.M., Beijersbergen, R.L., van 't Veer, L.J., Bernards, R. Mol. Cell. Biol. (1995)
- Genotoxic stress induces expression of E2F4, leading to its association with p130 in prostate carcinoma cells. DuPree, E.L., Mazumder, S., Almasan, A. Cancer Res. (2004)
- Mutations in the retinoblastoma-related gene RB2/p130 in adult T-cell leukaemia/lymphoma. Takeuchi, S., Takeuchi, N., Tsukasaki, K., Fermin, A.C., De Vas, S., Seo, H., Koeffler, H.P. Leuk. Lymphoma (2003)
- Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors. Cinti, C., Claudio, P.P., Howard, C.M., Neri, L.M., Fu, Y., Leoncini, L., Tosi, G.M., Maraldi, N.M., Giordano, A. Cancer Res. (2000)
- p130, p107, and pRb are differentially regulated in proliferating cells and during cell cycle arrest by alpha-interferon. Thomas, N.S., Pizzey, A.R., Tiwari, S., Williams, C.D., Yang, J. J. Biol. Chem. (1998)
- SV40 large T antigen promotes dephosphorylation of p130. Lin, J.Y., DeCaprio, J.A. J. Biol. Chem. (2003)
- Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4. Farkas, T., Hansen, K., Holm, K., Lukas, J., Bartek, J. J. Biol. Chem. (2002)
- The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells. Tyagi, A., Agarwal, C., Agarwal, R. Cell Cycle (2002)
- Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter. Araki, K., Nakajima, Y., Eto, K., Ikeda, M.A. Oncogene (2003)
- The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation. Zhang, B., Chen, W., Roman, A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2. Manié, S.N., Astier, A., Haghayeghi, N., Canty, T., Druker, B.J., Hirai, H., Freedman, A.S. J. Biol. Chem. (1997)
- Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo. Bouzahzah, B., Fu, M., Iavarone, A., Factor, V.M., Thorgeirsson, S.S., Pestell, R.G. Cancer Res. (2000)
- Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130. Smith-McCune, K., Kalman, D., Robbins, C., Shivakumar, S., Yuschenkoff, L., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation. Wang, S., Ghosh, R.N., Chellappan, S.P. Mol. Cell. Biol. (1998)
- Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB(-), p16INK4A(+) tumor cells. Cheng, L., Rossi, F., Fang, W., Mori, T., Cobrinik, D. J. Biol. Chem. (2000)
- E2F4 regulates a stable G(2) arrest response to genotoxic stress in prostate carcinoma. Crosby, M.E., Jacobberger, J., Gupta, D., Macklis, R.M., Almasan, A. Oncogene (2007)
- Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107. Barbie, T.U., Barbie, D.A., MacLaughlin, D.T., Maheswaran, S., Donahoe, P.K. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. Sterner, J.M., Dew-Knight, S., Musahl, C., Kornbluth, S., Horowitz, J.M. Mol. Cell. Biol. (1998)
- The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. Kong, L.J., Meloni, A.R., Nevins, J.R. Mol. Cell (2006)
- E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Moberg, K., Starz, M.A., Lees, J.A. Mol. Cell. Biol. (1996)
- pRB2/p130 target genes in non-small lung cancer cells identified by microarray analysis. Russo, G., Claudio, P.P., Fu, Y., Stiegler, P., Yu, Z., Macaluso, M., Giordano, A. Oncogene (2003)
- Retinoblastoma-related protein pRb2/p130 and suppression of tumor growth in vivo. Howard, C.M., Claudio, P.P., Gallia, G.L., Gordon, J., Giordano, G.G., Hauck, W.W., Khalili, K., Giordano, A. J. Natl. Cancer Inst. (1998)