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Gene Review

Actn4  -  actinin alpha 4

Mus musculus

Synonyms: Alpha-actinin-4, C77391, Non-muscle alpha-actinin 4
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Disease relevance of Actn4


High impact information on Actn4


Biological context of Actn4


Anatomical context of Actn4

  • Confocal immunofluorescence microscopy indicated that, while wild-type (WT) alpha-actinin-4 stains into actin cytoskeleton and cell surface ruffles, the mutated protein is only dispersed in the cytoplasm of the lung carcinoma cells [10].
  • Conversely, K256E alpha-actinin-4 was detected predominantly in the Triton-insoluble fraction, was excluded from cortical actin, and localized almost exclusively along stress fibers [11].

Associations of Actn4 with chemical compounds

  • To better study its progression, a transgenic mouse model was developed by expressing murine alpha-actinin-4 containing a mutation analogous to that affecting a human FSGS family in a podocyte-specific manner using the murine nephrin promoter [12].

Analytical, diagnostic and therapeutic context of Actn4


  1. Hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with alpha-actinin 4. Daniliuc, S., Bitterman, H., Rahat, M.A., Kinarty, A., Rosenzweig, D., Lahat, N., Nitza, L. J. Immunol. (2003) [Pubmed]
  2. Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin. Zhao, Z., Deocharan, B., Scherer, P.E., Ozelius, L.J., Putterman, C. J. Immunol. (2006) [Pubmed]
  3. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. Yao, J., Le, T.C., Kos, C.H., Henderson, J.M., Allen, P.G., Denker, B.M., Pollak, M.R. PLoS Biol. (2004) [Pubmed]
  4. {alpha}-Actinin-4 Is Required for Normal Podocyte Adhesion. Dandapani, S.V., Sugimoto, H., Matthews, B.D., Kolb, R.J., Sinha, S., Gerszten, R.E., Zhou, J., Ingber, D.E., Kalluri, R., Pollak, M.R. J. Biol. Chem. (2007) [Pubmed]
  5. The wt1-heterozygous mouse; a model to study the development of glomerular sclerosis. Menke, A.L., IJpenberg, A., Fleming, S., Ross, A., Medine, C.N., Patek, C.E., Spraggon, L., Hughes, J., Clarke, A.R., Hastie, N.D. J. Pathol. (2003) [Pubmed]
  6. Mice deficient in alpha-actinin-4 have severe glomerular disease. Kos, C.H., Le, T.C., Sinha, S., Henderson, J.M., Kim, S.H., Sugimoto, H., Kalluri, R., Gerszten, R.E., Pollak, M.R. J. Clin. Invest. (2003) [Pubmed]
  7. Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling. Dai, C., Stolz, D.B., Bastacky, S.I., St-Arnaud, R., Wu, C., Dedhar, S., Liu, Y. J. Am. Soc. Nephrol. (2006) [Pubmed]
  8. Cultured podocytes establish a size-selective barrier regulated by specific signaling pathways and demonstrate synchronized barrier assembly in a calcium switch model of junction formation. Hunt, J.L., Pollak, M.R., Denker, B.M. J. Am. Soc. Nephrol. (2005) [Pubmed]
  9. Effect of the knockdown of podocin mRNA on nephrin and alpha-actinin in mouse podocyte. Fan, Q., Ding, J., Zhang, J., Guan, N., Deng, J. Exp. Biol. Med. (Maywood) (2004) [Pubmed]
  10. Mutant alpha-actinin-4 promotes tumorigenicity and regulates cell motility of a human lung carcinoma. Menez, J., Le Maux Chansac, B., Dorothée, G., Vergnon, I., Jalil, A., Carlier, M.F., Chouaib, S., Mami-Chouaib, F. Oncogene (2004) [Pubmed]
  11. FSGS-associated alpha-actinin-4 (K256E) impairs cytoskeletal dynamics in podocytes. Michaud, J.L., Chaisson, K.M., Parks, R.J., Kennedy, C.R. Kidney Int. (2006) [Pubmed]
  12. Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant alpha-actinin-4. Michaud, J.L., Lemieux, L.I., Dubé, M., Vanderhyden, B.C., Robertson, S.J., Kennedy, C.R. J. Am. Soc. Nephrol. (2003) [Pubmed]
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