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Gene Review

RXRB  -  retinoid X receptor, beta

Homo sapiens

Synonyms: DAUDI6, H-2RIIBP, NR2B2, Nuclear receptor subfamily 2 group B member 2, RCoR-1, ...
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Disease relevance of RXRB


High impact information on RXRB


Chemical compound and disease context of RXRB


Biological context of RXRB


Anatomical context of RXRB


Associations of RXRB with chemical compounds


Other interactions of RXRB

  • Family studies revealed significant linkage disequilibrium between the RXRB alleles and a number of HLA-DPB1 alleles [9].
  • 1. A Val95Ala polymorphism of the RXRB gene, a Val227Ala polymorphism in the PPARA gene, and two synonymous single-nucleotide and CA repeat polymorphisms in the 5' region and 3' untranslated region of the NR4A2 gene were identified [10].
  • The RXRB gene was analysed as well as a splice-site variation of the butyrophilin-like (BTNL2) gene which is also located within the respective region [12].
  • CONCLUSION: Since a microsatellite flanking the RXRB gene and two intragenic polymorphisms are associated significantly with WG on chromosome 6p21.3, further investigations should be focussed on extensive fine-mapping in this region by densely mapping with additional markers such as SNPs [12].
  • The retinoid X receptor beta (RXR beta) gene is located 1.1 kb upstream of COL11A2 [15].

Analytical, diagnostic and therapeutic context of RXRB

  • A DNA-protein immunoprecipitation assay was developed with these antibodies, enabling the DNA-binding specificity of H-2RIIBP to be distinguished from that of an endogenous region II binding factor expressed in uninfected insect cells [16].


  1. Growth inhibitory retinoid effects after recruitment of retinoid X receptor beta to the retinoic acid receptor beta promoter. Cheung, B., Yan, J., Smith, S.A., Nguyen, T., Lee, M., Kavallaris, M., Norris, M.D., Haber, M., Marshall, G.M. Int. J. Cancer (2003) [Pubmed]
  2. Transcriptome analysis of endometrial cancer identifies peroxisome proliferator-activated receptors as potential therapeutic targets. Holland, C.M., Saidi, S.A., Evans, A.L., Sharkey, A.M., Latimer, J.A., Crawford, R.A., Charnock-Jones, D.S., Print, C.G., Smith, S.K. Mol. Cancer Ther. (2004) [Pubmed]
  3. Recombinant thyroid hormone receptor and retinoid X receptor stimulate ligand-dependent transcription in vitro. Lee, I.J., Driggers, P.H., Medin, J.A., Nikodem, V.M., Ozato, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. Retinoic acid-dependent transactivation of major histocompatibility complex class I promoters by the nuclear hormone receptor H-2RIIBP in undifferentiated embryonal carcinoma cells. Nagata, T., Segars, J.H., Levi, B.Z., Ozato, K. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Interaction of human beta 1 thyroid hormone receptor and its mutants with DNA and retinoid X receptor beta. T3 response element-dependent dominant negative potency. Meier, C.A., Parkison, C., Chen, A., Ashizawa, K., Meier-Heusler, S.C., Muchmore, P., Cheng, S.Y., Weintraub, B.D. J. Clin. Invest. (1993) [Pubmed]
  6. Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor. Bhat, M.K., Ashizawa, K., Cheng, S.Y. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation. Hallenbeck, P.L., Marks, M.S., Lippoldt, R.E., Ozato, K., Nikodem, V.M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Polymorphism of the human retinoid X receptor beta and linkage disequilibrium with HLA-DPB1. Rajsbaum, R., Fici, D., Fraser, P.A., Flores-Villanueva, P.O., Awdeh, Z.L. Tissue Antigens (2001) [Pubmed]
  9. Linkage disequilibrium between HLA-DPB1 alleles and retinoid X receptor beta haplotypes. Rajsbaum, R., Fici, D., Boggs, D.A., Fraser, P.A., Flores-Villanueva, P.O., Awdeh, Z.L. Hum. Immunol. (2002) [Pubmed]
  10. Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to alcohol dependence. Ishiguro, H., Okubo, Y., Ohtsuki, T., Yamakawa-Kobayashi, K., Arinami, T. Am. J. Med. Genet. (2002) [Pubmed]
  11. Mapping of RXRB to human chromosome 6p21.3. Fitzgibbon, J., Gillett, G.T., Woodward, K.J., Boyle, J.M., Wolfe, J., Povey, S. Ann. Hum. Genet. (1993) [Pubmed]
  12. On the Wegener granulomatosis associated region on chromosome 6p21.3. Szyld, P., Jagiello, P., Csernok, E., Gross, W.L., Epplen, J.T. BMC Med. Genet. (2006) [Pubmed]
  13. Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Swisshelm, K., Ryan, K., Lee, X., Tsou, H.C., Peacocke, M., Sager, R. Cell Growth Differ. (1994) [Pubmed]
  14. Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways. Segars, J.H., Marks, M.S., Hirschfeld, S., Driggers, P.H., Martinez, E., Grippo, J.F., Brown, M., Wahli, W., Ozato, K. Mol. Cell. Biol. (1993) [Pubmed]
  15. The human alpha 2(XI) collagen gene (COL11A2): completion of coding information, identification of the promoter sequence, and precise localization within the major histocompatibility complex reveal overlap with the KE5 gene. Lui, V.C., Ng, L.J., Sat, E.W., Cheah, K.S. Genomics (1996) [Pubmed]
  16. H-2RIIBP expressed from a baculovirus vector binds to multiple hormone response elements. Marks, M.S., Levi, B.Z., Segars, J.H., Driggers, P.H., Hirschfeld, S., Nagata, T., Appella, E., Ozato, K. Mol. Endocrinol. (1992) [Pubmed]
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