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Gene Review

TMPRSS2  -  transmembrane protease, serine 2

Homo sapiens

Synonyms: PP9284, PRSS10, Serine protease 10, Transmembrane protease serine 2
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Disease relevance of TMPRSS2


High impact information on TMPRSS2


Chemical compound and disease context of TMPRSS2


Biological context of TMPRSS2


Anatomical context of TMPRSS2


Associations of TMPRSS2 with chemical compounds

  • All five androgen-dependent xenografts showed as major transcript overexpression of two splice variants of TMPRSS2:ERG, linking TMPRSS2 exon 1 or 2 sequences to ERG exon 4 [5].
  • Using specific monoclonal antibodies, we show that the TMPRSS2-encoded serine protease is expressed as a Mr 70,000 full-length form and a cleaved Mr 32,000 protease domain [1].
  • In contrast, TMPRSS2 expression was up-regulated by the factor 0.9 when cells were stimulated by tetramethrin [12].

Other interactions of TMPRSS2

  • Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3 [10].
  • Treatment of LNCaP cells with the cellular immunopurified TMPRSS2 protease induced a transient increase in intracellular calcium, which is indicative of G-protein-coupled-receptor activation [11].
  • Functional studies in the Xenopus oocyte expression system demonstrated that prostasin increased ENaC currents 60--80%, whereas TMPRSS2 markedly decreased ENaC currents and protein levels [13].

Analytical, diagnostic and therapeutic context of TMPRSS2

  • In situ hybridization analyses of mouse embryos and adult tissues revealed that TMPRSS2 was expressed in the epithelia of the gastrointestinal, urogenital, and respiratory tracts [9].
  • In one such case, we confirmed the overexpression of ETV4 using quantitative PCR, and by rapid amplification of cDNA ends, quantitative PCR, and fluorescence in situ hybridization, we show that the TMPRSS2 (21q22) and ETV4 (17q21) loci are fused in this case [14].
  • We have characterized in detail the expression of TMPRSS2/ERG fusion mRNAs and correlated the isoforms expressed and expression levels with clinical outcome in cancers from men undergoing radical prostatectomy [6].


  1. Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. Afar, D.E., Vivanco, I., Hubert, R.S., Kuo, J., Chen, E., Saffran, D.C., Raitano, A.B., Jakobovits, A. Cancer Res. (2001) [Pubmed]
  2. Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium. Böttcher, E., Matrosovich, T., Beyerle, M., Klenk, H.D., Garten, W., Matrosovich, M. J. Virol. (2006) [Pubmed]
  3. The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease. Vaarala, M.H., Porvari, K., Kyllönen, A., Lukkarinen, O., Vihko, P. Int. J. Cancer (2001) [Pubmed]
  4. Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells. Jia, L., Shen, H.C., Wantroba, M., Khalid, O., Liang, G., Wang, Q., Gentzschein, E., Pinski, J.K., Stanczyk, F.Z., Jones, P.A., Coetzee, G.A. Mol. Cell. Biol. (2006) [Pubmed]
  5. TMPRSS2:ERG Fusion by Translocation or Interstitial Deletion Is Highly Relevant in Androgen-Dependent Prostate Cancer, But Is Bypassed in Late-Stage Androgen Receptor-Negative Prostate Cancer. Hermans, K.G., van Marion, R., van Dekken, H., Jenster, G., van Weerden, W.M., Trapman, J. Cancer Res. (2006) [Pubmed]
  6. Expression of Variant TMPRSS2/ERG Fusion Messenger RNAs Is Associated with Aggressive Prostate Cancer. Wang, J., Cai, Y., Ren, C., Ittmann, M. Cancer Res. (2006) [Pubmed]
  7. Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Lin, B., Ferguson, C., White, J.T., Wang, S., Vessella, R., True, L.D., Hood, L., Nelson, P.S. Cancer Res. (1999) [Pubmed]
  8. Evolutionary breakpoints on human chromosome 21. Davisson, M.T., Bechtel, L.J., Akeson, E.C., Fortna, A., Slavov, D., Gardiner, K. Genomics (2001) [Pubmed]
  9. Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. Vaarala, M.H., Porvari, K.S., Kellokumpu, S., Kyllönen, A.P., Vihko, P.T. J. Pathol. (2001) [Pubmed]
  10. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. Paoloni-Giacobino, A., Chen, H., Peitsch, M.C., Rossier, C., Antonarakis, S.E. Genomics (1997) [Pubmed]
  11. The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. Wilson, S., Greer, B., Hooper, J., Zijlstra, A., Walker, B., Quigley, J., Hawthorne, S. Biochem. J. (2005) [Pubmed]
  12. Characterisation of gene expression patterns in 22RV1 cells for determination of environmental androgenic/antiandrogenic compounds. Hartel, A., Didier, A., Pfaffl, M.W., Meyer, H.H. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  13. Regulation of the epithelial sodium channel by serine proteases in human airways. Donaldson, S.H., Hirsh, A., Li, D.C., Holloway, G., Chao, J., Boucher, R.C., Gabriel, S.E. J. Biol. Chem. (2002) [Pubmed]
  14. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Tomlins, S.A., Mehra, R., Rhodes, D.R., Smith, L.R., Roulston, D., Helgeson, B.E., Cao, X., Wei, J.T., Rubin, M.A., Shah, R.B., Chinnaiyan, A.M. Cancer Res. (2006) [Pubmed]
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