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Gene Review

TYS  -  sclerotylosis

Homo sapiens

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Disease relevance of TYS


High impact information on TYS

  • We have recently isolated TSC-22 (transforming growth factor beta-stimulated clone 22) cDNA as a new anticancer drug (Vesnarinone)-inducible gene in a human salivary gland cancer cell line, TYS [5].
  • Cultivation of TYS cells in the presence of sodium butyrate resulted in suppression of cell growth and production of secretory granules with amylase in the cytoplasm of the cells [1].
  • Expressions of CEA and amylase as well as ample tonofilaments were detected in cultured TYS cells [1].
  • The TYS cells, derived from the leukemia patient, revealed a monocytic appearance with microvilli at one side and had many granules and vacuoles [2].
  • The TYS cells, which phagocytized carbon particles and antibody-coated SRBC but not latex particles, released lysosomal enzymes and tumoricidal factor into the supernatant [2].

Biological context of TYS


Anatomical context of TYS


Associations of TYS with chemical compounds

  • In the present study, we investigated the mechanism of the induction of p21(waf1) gene by vesnarinone in TYS cells [8].
  • These findings suggest that overexpression of TSC-22 protein in TYS cells enhances the in vivo chemosensitivity of the cells to 5-FU via induction of apoptosis [11].

Regulatory relationships of TYS


Other interactions of TYS

  • We have recently isolated TSC-22 (transforming growth factor-beta-stimulated clone-22) cDNA as an anticancer, drug-inducible (with vesnarinone) gene in a human salivary gland cancer cell line, TYS [6].
  • Even some tripeptides, such as EYE, DYM, TYS and KYE, were recognized by HPK40, while none of the tested dipeptides was recognized as substrate [12].

Analytical, diagnostic and therapeutic context of TYS


  1. An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen. Yanagawa, T., Hayashi, Y., Yoshida, H., Yura, Y., Nagamine, S., Bando, T., Sato, M. Am. J. Pathol. (1986) [Pubmed]
  2. Establishment and characterization of human myelomonocytic (TYS) and histiocytic (TYH) cell lines. Haranaka, K., Satomi, N., Sakurai, A., Haranaka, R., Masuda, E., Ezoe, H., Obara, T., Miwa, S. Int. J. Cancer (1985) [Pubmed]
  3. Evaluation of the chemosensitivity of head and neck cancer cells based on the diverse function of mutated-p53. Shinagawa, Y., Kawamata, H., Omotehara, F., Nakashiro, K., Hoque, M.O., Furihata, T., Horiuchi, H., Imai, Y., Fujimori, T., Fujibayashi, T. Int. J. Oncol. (2003) [Pubmed]
  4. Transcriptional activation of cyclin-dependent kinase inhibitor, p21waf1 gene by treatment with a differentiation inducing agent, vesnarinone in a human salivary gland cancer cell line. Omotehara, F., Nakashiro, K., Uchida, D., Hino, S., Fujimori, T., Kawamata, H. J. Exp. Clin. Cancer Res. (2003) [Pubmed]
  5. Down-regulation of TSC-22 (transforming growth factor beta-stimulated clone 22) markedly enhances the growth of a human salivary gland cancer cell line in vitro and in vivo. Nakashiro, K., Kawamata, H., Hino, S., Uchida, D., Miwa, Y., Hamano, H., Omotehara, F., Yoshida, H., Sato, M. Cancer Res. (1998) [Pubmed]
  6. Over-expression of TSC-22 (TGF-beta stimulated clone-22) markedly enhances 5-fluorouracil-induced apoptosis in a human salivary gland cancer cell line. Uchida, D., Kawamata, H., Omotehara, F., Miwa, Y., Hino, S., Begum, N.M., Yoshida, H., Sato, M. Lab. Invest. (2000) [Pubmed]
  7. Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell. Kawamata, H., Nakashiro, K., Uchida, D., Hino, S., Omotehara, F., Yoshida, H., Sato, M. Br. J. Cancer (1998) [Pubmed]
  8. Vesnarinone, a differentiation inducing drug, directly activates p21(waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line. Omotehara, F., Kawamata, H., Uchida, D., Hino, S., Nakashiro, K., Fujimori, T. Br. J. Cancer (2002) [Pubmed]
  9. Induction of cyclin-dependent kinase inhibitor, p21WAF1, by treatment with 3,4-dihydro-6-[4-(3,4)-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinoline (vesnarinone) in a human salivary cancer cell line with mutant p53 gene. Sato, M., Kawamata, H., Harada, K., Nakashiro, K., Ikeda, Y., Gohda, H., Yoshida, H., Nishida, T., Ono, K., Kinoshita, M., Adachi, M. Cancer Lett. (1997) [Pubmed]
  10. Characteristics of antitumor activity of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]- 2(1H)-quinolinone (vesnarinone) against a human adenoid squamous carcinoma-forming cell line grown in athymic nude mice. Sato, M., Harada, K., Bando, T., Shirakami, T., Nakashiro, K., Yoshida, H., Nakai, S., Kawai, K., Adachi, M. Cancer Lett. (1995) [Pubmed]
  11. In vivo enhancement of chemosensitivity of human salivary gland cancer cells by overexpression of TGF-beta stimulated clone-22. Omotehara, F., Uchida, D., Hino, S., Begum, N.M., Yoshida, H., Sato, M., Kawamata, H. Oncol. Rep. (2000) [Pubmed]
  12. Substrate phosphorylation capacities of the major tyrosine protein kinase from the human promyelocytic cell line, HL-60. Ernould, A.P., Ferry, G., Barret, J.M., Genton, A., Boutin, J.A. Int. J. Pept. Protein Res. (1994) [Pubmed]
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