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Gene Review

Tsc22d1  -  TSC22 domain family, member 1

Mus musculus

Synonyms: AA589566, AW105905, Egr5, Kiaa1994, Regulatory protein TSC-22, ...
 
 
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Disease relevance of Tsc22d1

  • Polyclonal antibody was raised against TSC-22 protein expressed in Escherichia coli cells, and the antibody detected a 18-kDa protein in both the cytoplasmic and nuclear fractions of [35S]Met-labeled cells [1].
  • The fungistatic antibiotics trichostatins (TS) A and C were isolated from culture broth of Streptomyces platensis No. 145 and were found to be potent inducers of differentiation in murine erythroleukemia (Friend and RV133) cells at concentrations of 1.5 X 10(-8) M for TSA and 5 X 10(-7) M for TSC [2].
 

Psychiatry related information on Tsc22d1

  • These observations prompt discussion on the strong conservation of TSC-22 during evolution but also on its general function as a primary response gene expressed either when stimulated by several different factors during early human development, or in the adult in response to inducing differentiation signals [3].
 

High impact information on Tsc22d1

 

Biological context of Tsc22d1

 

Anatomical context of Tsc22d1

  • TSC-22 RNA accumulation and immunoreactivity were observed in follicles throughout the murine hair cycle, including the dermal papilla and lower epithelial strand of late-catagen hair follicles [6].
  • TSC-22 is also expressed in many neural crest-derived tissues including the mesenchyme of the branchial arches, the cranial, dorsal root, and sympathetic ganglia, as well as the facial cartilage and bone [7].
  • At later stages of development, TSC-22 was detected in the mesenchymal compartment of many tissues and organs, including the lung, trachea, kidney, stomach, intestine, tooth buds, and in precartilage condensations [8].
  • Furthermore, TSC-22 was highly expressed in the floor plate itself and notochord, and the endothelium lining the blood vessels, in particular the major arteries [8].
  • Although early TSC-22 expression is ubiquitous in 6.5 day embryos, as development proceeds TSC-22 expression is upregulated at sites of epithelial-mesenchymal interactions such as the limb bud, tooth primordiurn, hair follicle, kidney, lung, and pancreas [7].
 

Associations of Tsc22d1 with chemical compounds

  • TSC production of IL-6 was also decreased in castrated mice CONCLUSIONS: These data suggest that sex steroid ablation significantly enhances lymphopoiesis following auto-HSCT providing a new strategy for posttransplant immune reconstitution [9].
  • A phosphorylcholine (PC)-binding IgG (Mab2) antibody produced by a hybridoma derived from a BALB/c mouse which had been immunized against Trichinella spiralis was found to bind to the immunizing antigen (TSC) but not to other PC-associated antigens such as pneumococcal antigen (PNC) and PC-conjugated ovalbumin (PC-OVA) [10].
  • Examples of mouse models displaying altered renal transport function include targeted disruption of genes encoding the Na-H exchanger isoforms NHE2 and NHE3, the thiazide-sensitive Na-Cl cotransporter TSC, CFTR, and the colonic isoform of the H,K-ATPase [11].
 

Regulatory relationships of Tsc22d1

  • Experiments on TSC-22 expression in embryoid bodies of embryonic stem (ES) cells expressing dominant negative TGF-beta binding receptors initially supported this hypothesis [8].
 

Other interactions of Tsc22d1

  • We therefore propose that although TSC-22 may be a direct target of TGF-beta in late development, other factors are likely to be major regulators of expression at earlier stages [8].
  • Transforming growth factor-beta1-stimulated clone 22 (TSC-22) encodes a leucine zipper-containing protein that is highly conserved [12].
 

Analytical, diagnostic and therapeutic context of Tsc22d1

References

  1. Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. Shibanuma, M., Kuroki, T., Nose, K. J. Biol. Chem. (1992) [Pubmed]
  2. Effects of trichostatins on differentiation of murine erythroleukemia cells. Yoshida, M., Nomura, S., Beppu, T. Cancer Res. (1987) [Pubmed]
  3. Cloning of the human homologue of the TGF beta-stimulated clone 22 gene. Jay, P., Ji, J.W., Marsollier, C., Taviaux, S., Bergé-Lefranc, J.L., Berta, P. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  4. Down-regulation of TSC-22 (transforming growth factor beta-stimulated clone 22) markedly enhances the growth of a human salivary gland cancer cell line in vitro and in vivo. Nakashiro, K., Kawamata, H., Hino, S., Uchida, D., Miwa, Y., Hamano, H., Omotehara, F., Yoshida, H., Sato, M. Cancer Res. (1998) [Pubmed]
  5. A transient post-translationally modified form of cartilage type II collagen is ignored by self-reactive T cells. Yamada, H., Dzhambazov, B., Bockermann, R., Blom, T., Holmdahl, R. J. Immunol. (2004) [Pubmed]
  6. Profile of transforming growth factor-beta responses during the murine hair cycle. Soma, T., Dohrmann, C.E., Hibino, T., Raftery, L.A. J. Invest. Dermatol. (2003) [Pubmed]
  7. Dynamic expression of TSC-22 at sites of epithelial-mesenchymal interactions during mouse development. Dohrmann, C.E., Belaoussoff, M., Raftery, L.A. Mech. Dev. (1999) [Pubmed]
  8. Expression of TGF-beta stimulated clone-22 (TSC-22) in mouse development and TGF-beta signalling. Kester, H.A., Ward-van Oostwaard, T.M., Goumans, M.J., van Rooijen, M.A., van Der Saag, P.T., van Der Burg, B., Mummery, C.L. Dev. Dyn. (2000) [Pubmed]
  9. Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation. Goldberg, G.L., Sutherland, J.S., Hammet, M.V., Milton, M.K., Heng, T.S., Chidgey, A.P., Boyd, R.L. Transplantation (2005) [Pubmed]
  10. Structural analysis of a phosphorylcholine-binding antibody which exhibits a unique carrier specificity for Trichinella spiralis. Lim, P.L., Leung, D.T., Chui, Y.L., Ma, C.H. Mol. Immunol. (1994) [Pubmed]
  11. Tubule function in transgenic mice. Wang, T., Giebisch, G. Exp. Nephrol. (1998) [Pubmed]
  12. Role of TSC-22 during early embryogenesis in Xenopus laevis. Hashiguchi, A., Okabayashi, K., Asashima, M. Dev. Growth Differ. (2004) [Pubmed]
 
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