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Gene Review

WLS  -  wntless Wnt ligand secretion mediator

Homo sapiens

Synonyms: C1orf139, EVI, FLJ23091, GPR177, Integral membrane protein GPR177, ...
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Disease relevance of GPR177

  • Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients [1].
  • Reduction of 99mTc-sestamibi and 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function [2].

High impact information on GPR177

  • Thirteen cell lines with different levels of Pgp and MRP expression were used to assess the ability of calcein acetoxymethyl ester (calcein-AM) uptake and calcein efflux to measure Pgp and MRP functions, respectively [1].
  • RESULTS: A single dose of 60 mg diltiazem lowered the maximum resting anal sphincter pressure (MRP) by a mean of 21% [3].
  • Sequence homology can be widely spread over the whole molecule of MRP RNA and P RNA, such as those from Dictyostelium discoideum [4].
  • Illudin S was cytotoxic to a variety of multidrug-resistant tumor cell lines regardless of whether resistance was mediated by gp170/mdrl, gp180/MRP, GSHTR-pi, topoisomerase I, topoisomerase II, increased DNA repair capacity, or alterations in intracellular thiol content [5].
  • Rib-casein MRP exhibited significantly (p<0.05) advanced fluorescence development at three days, compared to Glc- and Fru-casein MRPs, which corresponded to marked (p<0.05) differences in greater UV absorption of Rib-casein MRPs later on after 15 days of processing [6].

Biological context of GPR177

  • The rMRP1 transfected cells, like their human ortholog, can confer drug resistance to vinca alkaloid (vinblastine and vincristine) and anthracycline drugs (daunorubcin and doxorubicin), and the resistance conferred by the MRP1 can be partially abolished by the MRP-specific inhibitors [7].
  • These findings suggest that MRP and MCS are present independently, and MCS is postulated to be a substance that catalyzes the Mg-dechelation reaction in the breakdown pathway of Chl, although MCS was not induced during senescence [8].
  • The current investigation examined the possibility of monitoring changes with respect to mRNA expression of multi-drug resistance associated protein (MRP) following antisense oligodeoxynucleotide (AS-ODN) treatment involving 99mTc-MIBI [9].
  • MRP mRNA expression levels were analyzed via the reverse transcription polymerase chain reaction (RT-PCR) [9].
  • The present study examined the influences of the muscle contraction (MCP) and relaxation (MRP) phases, as well as systole and diastole, on the blood velocity profile and flow in the conduit artery at different dynamic muscle contraction forces [10].

Anatomical context of GPR177

  • The purpose of this work was to compare linear and volumetric measurements of maxillary sinus (with and without lesion), using 3D (gold standard) and multiplanar reconstructions (MRP) by computed tomography in order to establish the precision and accuracy of these methods, determining which one would allow more effective assessments for this site [11].
  • PURPOSE: To evaluate the possible role of MR imaging in the assessment of patients with urinary tract obstruction by combining conventional MR imaging and MR pyelography (MRP) [12].
  • A higher blood flow furthermore appeared during the MRP compared to during the MCP, coinciding with a greater uniformity of the red blood cells moving at higher blood velocities during the MRP [10].
  • The time- and space-averaged, amplitude-weighted, mean (V(mean)) and maximum (V(max)) blood flow velocities were continuously measured in the common femoral artery during the cardiosystolic (CSP) and cardiodiastolic (CDP) phases during MCP and MRP, respectively [10].

Associations of GPR177 with chemical compounds

  • In 0.025-microm filtrates, free orthophosphate was the only MRP species present [13].
  • Between 40% and 58% of molybdate reactive P (MRP) and > 85% of molybdate unreactive P in the soil solution from the agricultural soils (pH 5.9-6.3) were associated with high molecular mass material (apparent size > 0.025 microm, or > 600 kDa on Superdex) [13].
  • Inhibitor studies showed that MCS and MRP had different susceptibilities to the inhibitors, especially to the chelators tiron and EDTA when Chlin was used as the substrate [8].
  • This review is mainly focused on the preparation of model MR product (MRP) of amino acid/monosaccharides and protein/polysaccharide, antioxidant effects of amino-sugar MRPs and protein-polysaccharide Maillard-type neoglycoproteins, and safety issues related to both types of the MRPs [14].
  • Rhodamine dye was used as a conservative tracer to compare the dilution behavior of the plume constituents MRP, NO(3)+NO(2), NH(4), Silicate, TDP, TDN, total bacteria, PC, and PN [15].

Analytical, diagnostic and therapeutic context of GPR177

  • In contrast, higher eukaryote MRP RNA structure models are based on comparative sequence analysis of only five sequences and limited probing data [16].
  • RT-PCR confirmed reduction of MRP mRNA in MCF-7/VP cells following AS-ODN treatment [9].
  • By using PCR as the gold standard method when dipstick assay was compared, matching results were obtained for 6 mosquitoes and, in one case MRP was positive while PCR was not reactive [17].
  • Cementless modular hip revision arthroplasty using the MRP Titan Revision Stem: outcome of 79 hips after an average of 4 years' follow-up [18].


  1. Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients. Legrand, O., Simonin, G., Perrot, J.Y., Zittoun, R., Marie, J.P. Blood (1998) [Pubmed]
  2. Reduction of 99mTc-sestamibi and 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function. Kinuya, S., Li, X.F., Yokoyama, K., Mori, H., Shiba, K., Watanabe, N., Shuke, N., Bunko, H., Michigishi, T., Tonami, N. Eur. J. Nucl. Med. Mol. Imaging (2003) [Pubmed]
  3. Topical diltiazem and bethanechol decrease anal sphincter pressure without side effects. Carapeti, E.A., Kamm, M.A., Evans, B.K., Phillips, R.K. Gut (1999) [Pubmed]
  4. Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA. Zhu, Y., Stribinskis, V., Ramos, K.S., Li, Y. RNA (2006) [Pubmed]
  5. Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells. Kelner, M.J., McMorris, T.C., Montoya, M.A., Estes, L., Rutherford, M., Samson, K.M., Taetle, R. Cancer Chemother. Pharmacol. (1997) [Pubmed]
  6. Chemical characterization of different sugar-casein Maillard reaction products and protective effects on chemical-induced cytotoxicity of Caco-2 cells. Jing, H., Kitts, D.D. Food Chem. Toxicol. (2004) [Pubmed]
  7. Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1). Yang, Z., Horn, M., Wang, J., Shen, D.D., Ho, R.J. AAPS PharmSci (2004) [Pubmed]
  8. Mg-dechelation activity in radish cotyledons with artificial and native substrates, Mg-chlorophyllin a and chlorophyllide a. Suzuki, T., Kunieda, T., Murai, F., Morioka, S., Shioi, Y. Plant Physiol. Biochem. (2005) [Pubmed]
  9. 99mTc-sestamibi to monitor treatment with antisense oligodeoxynucleotide complementary to MRP mRNA in human breast cancer cells. Kinuya, S., Bai, J., Shiba, K., Yokoyama, K., Mori, H., Fukuoka, M., Watanabe, N., Shuke, N., Michigishi, T., Tonami, N. Annals of nuclear medicine. (2006) [Pubmed]
  10. Alterations in the Blood Velocity Profile Influence the Blood Flow Response during Muscle Contractions and Relaxations. Osada, T., Rådegran, G. The journal of physiological sciences : JPS. (2006) [Pubmed]
  11. Volumetric and linear assessment of maxillary sinuses using computed tomography. Perrella, A., Albuquerque, M.A., Antunes, J.L., Cavalcanti, M.G. Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie. (2004) [Pubmed]
  12. MR pyelography and conventional MR imaging in urinary tract obstruction. Catalano, C., Pavone, P., Laghi, A., Scipioni, A., Panebianco, V., Brillo, R., Fraioli, F., Passariello, R. Acta radiologica (Stockholm, Sweden : 1987) (1999) [Pubmed]
  13. The role of colloidal particles in the speciation and analysis of "dissolved" phosphorus. Hens, M., Merckx, R. Water Res. (2002) [Pubmed]
  14. Production and use of Maillard products as oxidative stress modulators. Jing, H., Nakamura, S. Journal of medicinal food. (2005) [Pubmed]
  15. The effects of sewage discharge on water quality and phytoplankton of Hawai'ian coastal waters. Parnell, P.E. Mar. Environ. Res. (2003) [Pubmed]
  16. Secondary structure probing of the human RNase MRP RNA reveals the potential for MRP RNA subsets. Walker, S.C., Avis, J.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  17. Malaria Panel Assay versus PCR: detection of naturally infected Anopheles melas in a coastal village of Equatorial Guinea. Moreno, M., Cano, J., Nzambo, S., Bobuakasi, L., Buatiche, J.N., Ondo, M., Micha, F., Benito, A. Malar. J. (2004) [Pubmed]
  18. Cementless modular hip revision arthroplasty using the MRP Titan Revision Stem: outcome of 79 hips after an average of 4 years' follow-up. Schuh, A., Werber, S., Holzwarth, U., Zeiler, G. Archives of orthopaedic and trauma surgery. (2004) [Pubmed]
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