Disease relevance of ACSBG2

• CONCLUSION: The BGR-like gene may play an important role in spermatogenesis/testicular development and may be correlated with male infertility [1].
• Both immunoblastic lymphomas revealed monoclonal or aberrant B cells by FCI; 1 revealed a BGR [2].
• Both multiple myelomas revealed monoclonal plasma cells by FCI; 1 revealed a BGR [2].

High impact information on ACSBG2

• Human ACSBG1 and ACSBG2 amino acid sequences are 50% identical [3].
• ACSBG2 expression was confined to the testis and brainstem [3].
• Within a highly conserved motif known to be important for catalysis, human ACSBG2 contains a histidine residue where all other known acyl-CoA synthetases, including mouse and rat ACSBG2, contain an arginine [3].
• Immunohistochemistry and in situ hybridization studies further localized ACSBG2 expression to testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord [3].
• In transfected COS-1 cells, both human and murine ACSBG2 were detected as 75- to 80-kDa proteins by Western blot [3].

Biological context of ACSBG2

• Although the role of ACSBG2 in testicular and neuronal lipid metabolism remains unclear, the limited tissue expression pattern and limited substrate specificity rule out a likely role for this enzyme in X-linked adrenoleukodystrophy pathology [3].
• AIM: To investigate the roles of the BGR-like gene in testicular development/spermatogenesis [1].
• RT-PCR-based tissue distribution experiments showed that the BGR-like gene was exclusively expressed in testes and was a testes-specific isoform of the BGR gene [1].
• Homologous comparison showed that the BGR-like gene was a new alternative splicing variant of the BGR gene and had sequence homology with the bubblegum gene of human, mouse, rat and Drosophila [1].
• Specimens had been analyzed by polymerase chain reaction and/or Southern blot for T-cell and B-cell (immunoglobulin heavy chain and light chain genes) gene rearrangements (BGR) [2].

Anatomical context of ACSBG2

• The BGR-like gene transcript was imperceptibly expressed in human fetal testes, highly in human adult testes and moderately in elderly testes and human Leydig cells [1].
• However, the 1 case with no monoclonal/aberrant B cells by FCI revealed a BGR [2].

Associations of ACSBG2 with chemical compounds

• Cells overexpressing ACSBG2 had increased ability to activate oleic acid (C18:1omega9) and linoleic acid (C18:2omega6) but not other fatty acid substrates tested [3].
• The data indicate that BGR is lower in women at high altitude compared with the SL, possibly due to greater suppression of hepatic glucose production or stimulation of peripheral glucose uptake by insulin [4].
• We hypothesized that, in women, the blood glucose response to a meal (BGR) would be lower after exposure to 4,300 m compared with sea level (SL) and that BGR would be reduced in the presence of estrogen plus progesterone (E+P) relative to estrogen alone (E) [4].

Analytical, diagnostic and therapeutic context of ACSBG2

• Expression of the BGR-like gene was analyzed by reverse transcription-polymerase chain reaction (RT-PCR) [1].
• By multiple tissue RNA array and Northern blot analyses, human BGR mRNA was exclusively detected in testes [5].

References