Gene Review:
AKAP5 - A kinase (PRKA) anchor protein 5
Homo sapiens
Synonyms:
A-kinase anchor protein 5, A-kinase anchor protein 79 kDa, AKAP 79, AKAP-5, AKAP75, ...
- Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals. Indolfi, C., Stabile, E., Coppola, C., Gallo, A., Perrino, C., Allevato, G., Cavuto, L., Torella, D., Di Lorenzo, E., Troncone, G., Feliciello, A., Avvedimento, E., Chiariello, M. Circ. Res. (2001)
- Cholera toxin induces cAMP-independent degradation of Gs. Chang, F.H., Bourne, H.R. J. Biol. Chem. (1989)
- Hemoglobin Old Dominion/Burton-upon-Trent, beta 143 (H21) His-->Tyr, codon 143 CAC-->TAC--a variant with altered oxygen affinity that compromises measurement of glycated hemoglobin in diabetes mellitus: structure, function, and DNA sequence. Elder, G.E., Lappin, T.R., Horne, A.B., Fairbanks, V.F., Jones, R.T., Winter, P.C., Green, B.N., Hoyer, J.D., Reynolds, T.M., Shih, D.T., McCormick, D.J., Kubik, K.S., Madden, B.J., Head, C.G., Harvey, D., Roberts, N.B. Mayo Clin. Proc. (1998)
- Distinct enzyme combinations in AKAP signalling complexes permit functional diversity. Hoshi, N., Langeberg, L.K., Scott, J.D. Nat. Cell Biol. (2005)
- Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Colledge, M., Dean, R.A., Scott, G.K., Langeberg, L.K., Huganir, R.L., Scott, J.D. Neuron (2000)
- Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells. Jänicke, R.U., Lee, F.H., Porter, A.G. Mol. Cell. Biol. (1994)
- AKAP79-mediated Targeting of the Cyclic AMP-dependent Protein Kinase to the beta1-Adrenergic Receptor Promotes Recycling and Functional Resensitization of the Receptor. Gardner, L.A., Tavalin, S.J., Goehring, A.S., Scott, J.D., Bahouth, S.W. J. Biol. Chem. (2006)
- Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus. Ulfig, N., Chan, W.Y. Neurosignals (2002)
- Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79. Altier, C., Dubel, S.J., Barrère, C., Jarvis, S.E., Stotz, S.C., Spaetgens, R.L., Scott, J.D., Cornet, V., De Waard, M., Zamponi, G.W., Nargeot, J., Bourinet, E. J. Biol. Chem. (2002)
- Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. Carr, D.W., Stofko-Hahn, R.E., Fraser, I.D., Cone, R.D., Scott, J.D. J. Biol. Chem. (1992)
- Mutagenesis of the regulatory subunit (RII beta) of cAMP-dependent protein kinase II beta reveals hydrophobic amino acids that are essential for RII beta dimerization and/or anchoring RII beta to the cytoskeleton. Li, Y., Rubin, C.S. J. Biol. Chem. (1995)
- Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton. Glantz, S.B., Li, Y., Rubin, C.S. J. Biol. Chem. (1993)
- Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta. Hirsch, A.H., Glantz, S.B., Li, Y., You, Y., Rubin, C.S. J. Biol. Chem. (1992)
- Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover. Dodge, K.L., Carr, D.W., Sanborn, B.M. Endocrinology (1999)
- Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. Dart, C., Leyland, M.L. J. Biol. Chem. (2001)
- RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells. Lynch, M.J., Baillie, G.S., Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G., Houslay, M.D. J. Biol. Chem. (2005)
- Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. Cong, M., Perry, S.J., Lin, F.T., Fraser, I.D., Hu, L.A., Chen, W., Pitcher, J.A., Scott, J.D., Lefkowitz, R.J. J. Biol. Chem. (2001)
- Identification of an IQGAP1/AKAP79 complex in beta-cells. Nauert, J.B., Rigas, J.D., Lester, L.B. J. Cell. Biochem. (2003)
- The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT. Rodríguez, A., Martínez-Martínez, S., López-Maderuelo, M.D., Ortega-Pérez, I., Redondo, J.M. J. Biol. Chem. (2005)
- Anchoring and scaffold proteins for kinases and phosphatases. Lester, L.B., Scott, J.D. Recent Prog. Horm. Res. (1997)
- Localization of the A kinase anchoring protein AKAP79 in the human hippocampus. Sík, A., Gulácsi, A., Lai, Y., Doyle, W.K., Pacia, S., Mody, I., Freund, T.F. Eur. J. Neurosci. (2000)
- AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site. Tavalin, S.J. J. Biol. Chem. (2008)
- Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells. Xie, G., Raufman, J.P. Am. J. Physiol. Gastrointest. Liver Physiol. (2001)
- The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells. Paolillo, M., Feliciello, A., Porcellini, A., Garbi, C., Bifulco, M., Schinelli, S., Ventra, C., Stabile, E., Ricciardelli, G., Schettini, G., Avvedimento, E.V. J. Biol. Chem. (1999)
- An alphoid DNA sequence conserved in all human and great ape chromosomes: evidence for ancient centromeric sequences at human chromosomal regions 2q21 and 9q13. Baldini, A., Ried, T., Shridhar, V., Ogura, K., D'Aiuto, L., Rocchi, M., Ward, D.C. Hum. Genet. (1993)