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Gene Review

MPK1  -  mitogen-activated protein kinase 1

Arabidopsis thaliana

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Disease relevance of ATMPK1


High impact information on ATMPK1


Biological context of ATMPK1


Anatomical context of ATMPK1


Associations of ATMPK1 with chemical compounds


Regulatory relationships of ATMPK1


Other interactions of ATMPK1


Analytical, diagnostic and therapeutic context of ATMPK1

  • Northern blot analysis indicates that the ATMPK1 and ATMPK2 mRNAs are significantly present in all the organs except seeds [1].
  • Here, we show that a rice (Oryza sativa) MAPK, OsMAPK6, was posttranslationally activated in a cell culture by a sphingolipid elicitor [21].
  • Molecular cloning and mRNA expression analysis of a novel rice (Oryzasativa L.) MAPK kinase kinase, OsEDR1, an ortholog of Arabidopsis AtEDR1, reveal its role in defense/stress signalling pathways and development [22].


  1. Characterization of two cDNAs that encode MAP kinase homologues in Arabidopsis thaliana and analysis of the possible role of auxin in activating such kinase activities in cultured cells. Mizoguchi, T., Gotoh, Y., Nishida, E., Yamaguchi-Shinozaki, K., Hayashida, N., Iwasaki, T., Kamada, H., Shinozaki, K. Plant J. (1994) [Pubmed]
  2. RNA interference-based (RNAi) suppression of AtMPK6, an Arabidopsis mitogen-activated protein kinase, results in hypersensitivity to ozone and misregulation of AtMPK3. Miles, G.P., Samuel, M.A., Zhang, Y., Ellis, B.E. Environ. Pollut. (2005) [Pubmed]
  3. Suppression of auxin signal transduction by a MAPK cascade in higher plants. Kovtun, Y., Chiu, W.L., Zeng, W., Sheen, J. Nature (1998) [Pubmed]
  4. Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis. Ulm, R., Revenkova, E., di Sansebastiano, G.P., Bechtold, N., Paszkowski, J. Genes Dev. (2001) [Pubmed]
  5. Increased expression of MAP KINASE KINASE7 causes deficiency in polar auxin transport and leads to plant architectural abnormality in Arabidopsis. Dai, Y., Wang, H., Li, B., Huang, J., Liu, X., Zhou, Y., Mou, Z., Li, J. Plant Cell (2006) [Pubmed]
  6. Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis. Liu, Y., Zhang, S. Plant Cell (2004) [Pubmed]
  7. Silencing of the mitogen-activated protein kinase MPK6 compromises disease resistance in Arabidopsis. Menke, F.L., van Pelt, J.A., Pieterse, C.M., Klessig, D.F. Plant Cell (2004) [Pubmed]
  8. Connecting oxidative stress, auxin, and cell cycle regulation through a plant mitogen-activated protein kinase pathway. Hirt, H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. The ethylene hormone response in Arabidopsis: a eukaryotic two-component signaling system. Chang, C., Meyerowitz, E.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  10. A semidominant mutation in an Arabidopsis mitogen-activated protein kinase phosphatase-like gene compromises cortical microtubule organization. Naoi, K., Hashimoto, T. Plant Cell (2004) [Pubmed]
  11. The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin. M??sz??ros, T., Helfer, A., Hatzimasoura, E., Magyar, Z., Serazetdinova, L., Rios, G., Bard??czy, V., Teige, M., Koncz, C., Peck, S., B??gre, L. Plant J. (2006) [Pubmed]
  12. Oxidative stress activates ATMPK6, an Arabidopsis homologue of MAP kinase. Yuasa, T., Ichimura, K., Mizoguchi, T., Shinozaki, K. Plant Cell Physiol. (2001) [Pubmed]
  13. Mitogen-activated protein kinase signaling in postgermination arrest of development by abscisic acid. Lu, C., Han, M.H., Guevara-Garcia, A., Fedoroff, N.V. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  14. Ethylene hormone receptor action in Arabidopsis. Chang, C., Stadler, R. Bioessays (2001) [Pubmed]
  15. SCD1 is required for cytokinesis and polarized cell expansion in Arabidopsis thaliana [corrected]. Falbel, T.G., Koch, L.M., Nadeau, J.A., Segui-Simarro, J.M., Sack, F.D., Bednarek, S.Y. Development (2003) [Pubmed]
  16. Activation of the NaCl- and drought-induced RD29A and RD29B promoters by constitutively active Arabidopsis MAPKK or MAPK proteins. Hua, Z.M., Yang, X., Fromm, M.E. Plant Cell Environ. (2006) [Pubmed]
  17. A transmembrane hybrid-type histidine kinase in Arabidopsis functions as an osmosensor. Urao, T., Yakubov, B., Satoh, R., Yamaguchi-Shinozaki, K., Seki, M., Hirayama, T., Shinozaki, K. Plant Cell (1999) [Pubmed]
  18. Stress-induced protein phosphatase 2C is a negative regulator of a mitogen-activated protein kinase. Meskiene, I., Baudouin, E., Schweighofer, A., Liwosz, A., Jonak, C., Rodriguez, P.L., Jelinek, H., Hirt, H. J. Biol. Chem. (2003) [Pubmed]
  19. ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation. Huang, Y., Li, H., Gupta, R., Morris, P.C., Luan, S., Kieber, J.J. Plant Physiol. (2000) [Pubmed]
  20. Ethylene signaling pathway. Stepanova, A.N., Alonso, J.M. Sci. STKE (2005) [Pubmed]
  21. A sphingolipid elicitor-inducible mitogen-activated protein kinase is regulated by the small GTPase OsRac1 and heterotrimeric G-protein in rice 1[w]. Lieberherr, D., Thao, N.P., Nakashima, A., Umemura, K., Kawasaki, T., Shimamoto, K. Plant Physiol. (2005) [Pubmed]
  22. Molecular cloning and mRNA expression analysis of a novel rice (Oryzasativa L.) MAPK kinase kinase, OsEDR1, an ortholog of Arabidopsis AtEDR1, reveal its role in defense/stress signalling pathways and development. Kim, J.A., Agrawal, G.K., Rakwal, R., Han, K.S., Kim, K.N., Yun, C.H., Heu, S., Park, S.Y., Lee, Y.H., Jwa, N.S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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