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Gene Review

Ppp1r9a  -  protein phosphatase 1, regulatory subunit 9A

Rattus norvegicus

Synonyms: Neurabin-1, Neurabin-I, Neural tissue-specific F-actin-binding protein I, PP1bp175, Protein phosphatase 1 regulatory subunit 9A, ...
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High impact information on Ppp1r9a


Biological context of Ppp1r9a

  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation [4].
  • Reduction of endogenous neurabin levels by interference RNA (RNAi)-mediated knockdown also inhibited the surface expression of GluR1 receptors [4].
  • In contrast, dimerization of neurabin-I via C-terminal coiled-coil domains and association of protein phosphatase-1 (PP1) with neurabin-I through a canonical KIXF motif inhibited filopodia [4].
  • Furthermore, the expression of a neurabin-I polypeptide unable to bind PP1 delayed the maturation of neuronal filopodia into spines, reduced the synaptic targeting of AMPA-type glutamate (GluR1) receptors, and decreased AMPA receptor-mediated synaptic transmission [4].
  • The target sizes estimated from the radiation-induced loss of intensity of p40, p70 and p180 were all approx. 190 kDa, suggesting that NaPi-2 exists as an oligomeric protein in which the subunits are sufficiently close to one another to allow substantial energy transfer between the monomers [5].

Anatomical context of Ppp1r9a

  • In a preceding paper, we reported a novel actin filament (F-actin)-binding protein, named neurabin, which was specifically expressed in neural tissue and implicated in neurite formation [6].
  • PP1bp175, PP1bp134, PP1bp75, and PP1C were partially released from forebrain particulate extracts by incubation at low ionic strength, which destabilizes the actin cytoskeleton [7].
  • A series of experiments designed to characterize these proteins indicated that p115 and p180 were focal adhesion kinase (FAK) and platelet-derived growth factor receptor beta (PDGF-Rbeta), respectively, and that stretch augmented the surface-expression of PDGF-Rbeta in PASMC but not in PAEC [8].
  • Here, we show that the neuronal actin- and protein phosphatase-1-binding protein, neurabin-I, promotes filopodia in neurons and nonneuronal cells [4].
  • In both cell types, rab3D displayed preferential localization to secretory vesicles that were identified using specific antibodies against Clara Cell Secretory Protein and p180 lamellar body protein, respectively [9].

Associations of Ppp1r9a with chemical compounds

  • Phosphate transport activity decreased with increasing concentrations of reducing agents [beta-mercaptoethanol, dithiothreitol and tris-(2-carboxyethyl)phosphine] and was linearly correlated with the amount of p180 detected [5].
  • Plasma membrane p180, which insulin receptor phosphorylates in vivo, is not a tyrosine kinase [10].

Other interactions of Ppp1r9a

  • We purified from rat brain another F-actin-binding protein, which had a domain organization similar to that of neurabin but was ubiquitously expressed, and named it neurabin-II [6].

Analytical, diagnostic and therapeutic context of Ppp1r9a


  1. The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Ryan, X.P., Alldritt, J., Svenningsson, P., Allen, P.B., Wu, G.Y., Nairn, A.C., Greengard, P. Neuron (2005) [Pubmed]
  2. Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation. Nakanishi, H., Obaishi, H., Satoh, A., Wada, M., Mandai, K., Satoh, K., Nishioka, H., Matsuura, Y., Mizoguchi, A., Takai, Y. J. Cell Biol. (1997) [Pubmed]
  3. Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Burnett, P.E., Blackshaw, S., Lai, M.M., Qureshi, I.A., Burnett, A.F., Sabatini, D.M., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. Terry-Lorenzo, R.T., Roadcap, D.W., Otsuka, T., Blanpied, T.A., Zamorano, P.L., Garner, C.C., Shenolikar, S., Ehlers, M.D. Mol. Biol. Cell (2005) [Pubmed]
  5. Involvement of disulphide bonds in the renal sodium/phosphate co-transporter NaPi-2. Xiao, Y., Boyer, C.J., Vincent, E., Dugré, A., Vachon, V., Potier, M., Béliveau, R. Biochem. J. (1997) [Pubmed]
  6. Neurabin-II/spinophilin. An actin filament-binding protein with one pdz domain localized at cadherin-based cell-cell adhesion sites. Satoh, A., Nakanishi, H., Obaishi, H., Wada, M., Takahashi, K., Satoh, K., Hirao, K., Nishioka, H., Hata, Y., Mizoguchi, A., Takai, Y. J. Biol. Chem. (1998) [Pubmed]
  7. Association of brain protein phosphatase 1 with cytoskeletal targeting/regulatory subunits. Colbran, R.J., Bass, M.A., McNeill, R.B., Bollen, M., Zhao, S., Wadzinski, B.E., Strack, S. J. Neurochem. (1997) [Pubmed]
  8. Mechanical stretch augments PDGF receptor beta expression and protein tyrosine phosphorylation in pulmonary artery tissue and smooth muscle cells. Tanabe, Y., Saito, M., Ueno, A., Nakamura, M., Takeishi, K., Nakayama, K. Mol. Cell. Biochem. (2000) [Pubmed]
  9. Rab3D and actin reveal distinct lamellar body subpopulations in alveolar epithelial type II cells. van Weeren, L., de Graaff, A.M., Jamieson, J.D., Batenburg, J.J., Valentijn, J.A. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  10. Plasma membrane p180, which insulin receptor phosphorylates in vivo, is not a tyrosine kinase. Goren, H.J., Boland, D., Fei, Q. Cell. Signal. (1993) [Pubmed]
  11. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. Terry-Lorenzo, R.T., Carmody, L.C., Voltz, J.W., Connor, J.H., Li, S., Smith, F.D., Milgram, S.L., Colbran, R.J., Shenolikar, S. J. Biol. Chem. (2002) [Pubmed]
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