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Gene Review

GPX1  -  glutathione peroxidase GPX1

Saccharomyces cerevisiae S288c

Synonyms: Glutathione peroxidase 1, YKL026C
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Disease relevance of GPX1


High impact information on GPX1


Biological context of GPX1


Anatomical context of GPX1

  • We propose a model in which the glutathione peroxidase activity of glutaredoxins converts hydroperoxides to their corresponding alcohols; these can then be conjugated to GSH by glutathione-S-transferases and transported into the vacuole by Ycf1 [9].
  • Co-expression of the BI-GST/GPX protein brought the total glutathione levels back to normal and re-established the mitochondrial membrane potential but had no effect on the phospholipid alterations [10].
  • In the group supplemented with selenium-yeast, the activities of GSH-Px, CAT, and SOD were significantly increased in erythrocytes, whereas GST activity and plasma content of GSH + GSSG were reduced compared with the controls [11].
  • Testis GSH-Px activity increased from weaning to 145 kg BW even when Se was not added to the diet [12].
  • The correlation between pancreas Se level and GSH-Px activity was .36 (P less than .05) [13].

Associations of GPX1 with chemical compounds


Other interactions of GPX1

  • It was found that super oxide dismutase (SOD1 and SOD2), catalase and glutathione peroxidase (GPx) all are over expressed in CR [16].
  • We recently reported that Grx1 is active as a glutathione peroxidase and can directly reduce hydroperoxides (Collinson, E. J., Wheeler, G. L., Garrido, E. O., Avery, A. M., Avery, S. V., and Grant, C. M. (2002) J. Biol. Chem. 277, 16712-16717) [17].

Analytical, diagnostic and therapeutic context of GPX1


  1. Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. Avery, A.M., Avery, S.V. J. Biol. Chem. (2001) [Pubmed]
  2. A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation. Delaunay, A., Pflieger, D., Barrault, M.B., Vinh, J., Toledano, M.B. Cell (2002) [Pubmed]
  3. GPX2, encoding a phospholipid hydroperoxide glutathione peroxidase homologue, codes for an atypical 2-Cys peroxiredoxin in Saccharomyces cerevisiae. Tanaka, T., Izawa, S., Inoue, Y. J. Biol. Chem. (2005) [Pubmed]
  4. Peroxiredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. Wong, C.M., Siu, K.L., Jin, D.Y. J. Biol. Chem. (2004) [Pubmed]
  5. The yeast prion protein Ure2 shows glutathione peroxidase activity in both native and fibrillar forms. Bai, M., Zhou, J.M., Perrett, S. J. Biol. Chem. (2004) [Pubmed]
  6. Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. Inoue, Y., Matsuda, T., Sugiyama, K., Izawa, S., Kimura, A. J. Biol. Chem. (1999) [Pubmed]
  7. Effect of organic and inorganic selenium sources and levels on sow colostrum and milk selenium content. Mahan, D.C. J. Anim. Sci. (2000) [Pubmed]
  8. Comparative effects of high dietary levels of organic and inorganic selenium on selenium toxicity of growing-finishing pigs. Kim, Y.Y., Mahan, D.C. J. Anim. Sci. (2001) [Pubmed]
  9. The yeast glutaredoxins are active as glutathione peroxidases. Collinson, E.J., Wheeler, G.L., Garrido, E.O., Avery, A.M., Avery, S.V., Grant, C.M. J. Biol. Chem. (2002) [Pubmed]
  10. A novel plant glutathione S-transferase/peroxidase suppresses Bax lethality in yeast. Kampranis, S.C., Damianova, R., Atallah, M., Toby, G., Kondi, G., Tsichlis, P.N., Makris, A.M. J. Biol. Chem. (2000) [Pubmed]
  11. The effect of selenium on antioxidant system in erythrocytes and liver of the carp (Cyprinus carpio L.). Jovanovic, A., Grubor-Lajsic, G., Djukic, N., Gardinovacki, G., Matic, A., Spasic, M. Critical reviews in food science and nutrition. (1997) [Pubmed]
  12. Effects of dietary selenium and vitamin E on boar performance and tissue responses, semen quality, and subsequent fertilization rates in mature gilts. Marin-Guzman, J., Mahan, D.C., Chung, Y.K., Pate, J.L., Pope, W.F. J. Anim. Sci. (1997) [Pubmed]
  13. Effect of supplemental selenium on pancreatic function and nutrient digestibility in the pig. Adkins, R.S., Ewan, R.C. J. Anim. Sci. (1984) [Pubmed]
  14. Glutathione and glutathione metabolizing enzymes in yeasts. Casalone, E., Di Ilio, C., Federici, G., Polsinelli, M. Antonie Van Leeuwenhoek (1988) [Pubmed]
  15. Prolonged feeding of high dietary levels of organic and inorganic selenium to gilts from 25 kg body weight through one parity. Kim, Y.Y., Mahan, D.C. J. Anim. Sci. (2001) [Pubmed]
  16. Caloric restriction augments ROS defense in S. cerevisiae, by a Sir2p independent mechanism. Agarwal, S., Sharma, S., Agrawal, V., Roy, N. Free Radic. Res. (2005) [Pubmed]
  17. Role of yeast glutaredoxins as glutathione S-transferases. Collinson, E.J., Grant, C.M. J. Biol. Chem. (2003) [Pubmed]
  18. Purification, crystallization and preliminary X-ray analysis of glutathione peroxidase Gpx3 from Saccharomyces cerevisiae. Yang, Z., Zhou, C.Z. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
  19. Oxidative stress response in yeast: glutathione peroxidase of Hansenula mrakii is bound to the membrane of both mitochondria and cytoplasm. Inoue, Y., Tran, L.T., Kamakura, M., Izawa, S., Miki, T., Tsujimoto, Y., Kimura, A. Biochim. Biophys. Acta (1995) [Pubmed]
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