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Slc5a7  -  solute carrier family 5 (sodium/choline...

Rattus norvegicus

Synonyms: CHT, Cht1, Hemicholinium-3-sensitive choline transporter, High affinity choline transporter 1, Solute carrier family 5 member 7
 
 
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Disease relevance of Slc5a7

 

High impact information on Slc5a7

 

Biological context of Slc5a7

  • In a separate experiment, we also showed that LF 16-0687MS at 100 microg/kg/min given either 1 h before or 30 min after CHT did not affect mean arterial blood pressure [8].
  • Such an enhancement in endothelium-dependent vasorelaxation was not found in CHT rats (R(max): 48.4 +/- 7.8%) [9].
  • A hypoxia-induced decrease in L-arginine bioavailability resulting from acclimatization at altitude may be involved in this limitation of the NO pathway in CH and CHT rats [1].
 

Anatomical context of Slc5a7

 

Associations of Slc5a7 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Slc5a7

References

  1. Chronic hypoxia exposure depresses aortic endothelium-dependent vasorelaxation in both sedentary and trained rats: involvement of L-arginine. Reboul, C., Tanguy, S., Gibault, A., Dauzat, M., Obert, P. J. Appl. Physiol. (2005) [Pubmed]
  2. Cardiac remodeling and functional adaptations consecutive to altitude training in rats: implications for sea level aerobic performance. Reboul, C., Tanguy, S., Juan, J.M., Dauzat, M., Obert, P. J. Appl. Physiol. (2005) [Pubmed]
  3. Development of cholinergic neurons in rat brain regions: dose-dependent effects of propylthiouracil-induced hypothyroidism. Sawin, S., Brodish, P., Carter, C.S., Stanton, M.E., Lau, C. Neurotoxicology and teratology. (1998) [Pubmed]
  4. High-affinity choline transport in proteoliposomes derived from rat cortical synaptosomes. Meyer, E.M., Cooper, J.R. Science (1982) [Pubmed]
  5. Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia. Lecomte, M.J., De Gois, S., Guerci, A., Ravassard, P., Faucon Biguet, N., Mallet, J., Berrard, S. Mol. Cell. Neurosci. (2005) [Pubmed]
  6. Dihydrotestosterone increases hippocampal N-methyl-D-aspartate binding but does not affect choline acetyltransferase cell number in the forebrain or choline transporter levels in the CA1 region of adult male rats. Romeo, R.D., Staub, D., Jasnow, A.M., Karatsoreos, I.N., Thornton, J.E., McEwen, B.S. Endocrinology (2005) [Pubmed]
  7. Constitutive high-affinity choline transporter endocytosis is determined by a carboxyl-terminal tail dileucine motif. Ribeiro, F.M., Black, S.A., Cregan, S.P., Prado, V.F., Prado, M.A., Rylett, R.J., Ferguson, S.S. J. Neurochem. (2005) [Pubmed]
  8. Effect of LF 16-0687MS, a new nonpeptide bradykinin B2 receptor antagonist, in a rat model of closed head trauma. Pruneau, D., Chorny, I., Benkovitz, V., Artru, A., Roitblat, L., Shapira, Y. J. Neurotrauma (1999) [Pubmed]
  9. Altitude negates the benefits of aerobic training on the vascular adaptations in rats. Reboul, C., Tanguy, S., Dauzat, M., Obert, P. Medicine and science in sports and exercise. (2005) [Pubmed]
  10. Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin. Haberberger, R.V., Pfeil, U., Lips, K.S., Kummer, W. J. Invest. Dermatol. (2002) [Pubmed]
  11. Expression of the high-affinity choline transporter, CHT1, in the rat trachea. Pfeil, U., Lips, K.S., Eberling, L., Grau, V., Haberberger, R.V., Kummer, W. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  12. Ultrastructural localization of high-affinity choline transporter in the rat neuromuscular junction: enrichment on synaptic vesicles. Nakata, K., Okuda, T., Misawa, H. Synapse (2004) [Pubmed]
  13. Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood-brain barrier. Geldenhuys, W.J., Lockman, P.R., Philip, A.E., McAfee, J.H., Miller, B.L., McCurdy, C.R., Allen, D.D. Journal of drug targeting. (2005) [Pubmed]
  14. Expression of the high-affinity choline transporter CHT1 in epithelia. Pfeil, U., Haberberger, R.V., Lips, K.S., Eberling, L., Grau, V., Kummer, W. Life Sci. (2003) [Pubmed]
  15. Stereoselectivity of the inhibition of [3H]hemicholinium-3 binding to the sodium-dependent high-affinity choline transporter by the enantiomers of alpha- and beta-methylcholine. Ferguson, S.S., Collier, B. J. Neurochem. (1994) [Pubmed]
  16. Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs. Patel, P.J., Messer, W.S., Hudson, R.A. J. Med. Chem. (1993) [Pubmed]
  17. Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4). Friedrich, A., George, R.L., Bridges, C.C., Prasad, P.D., Ganapathy, V. Biochim. Biophys. Acta (2001) [Pubmed]
 
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