The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Slc5a7  -  solute carrier family 5 (choline...

Mus musculus

Synonyms: CHT, CHT1, Cht1, Hemicholinium-3-sensitive choline transporter, High affinity choline transporter 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Slc5a7

  • A better understanding of modes of CHT regulation should allow for experimental manipulation of cholinergic signaling in vivo with potential utility in human disorders of known cholinergic dysfunction such as Alzheimer's disease, Parkinson's disease, schizophrenia, Huntington's disease, and dysautonomia [1].
  • Analysis of this hypothesis in vivo is limited in mammals because of the toxicity of CHT antagonists and the early postnatal lethality of CHT-/- mice (Ferguson et al., 2004) [2].

Psychiatry related information on Slc5a7

  • In Caenorhabditis elegans, in which cholinergic signaling supports motor activity and mutant alleles impacting ACh secretion and response can be propagated, we investigated the contribution of CHT (CHO-1) to facets of cholinergic neurobiology [2].

High impact information on Slc5a7


Biological context of Slc5a7


Anatomical context of Slc5a7

  • In the spinal cord, CHT mRNA was present at close to adult levels at the earliest time point examined (E14) and showed almost no changes after birth [7].
  • Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system [9].
  • CHT-containing fibers were also present in sensory and limbic thalamic nuclei, preoptic and hypothalamic areas, and the floccular lobe of the cerebellum [9].
  • In mouse crude striatal and hippocampal synaptosomes, PKC activators beta-phorbol 12-myristate 13-acetate (beta-PMA) and beta-phorbol 12,13-dibutyrate produced time- and concentration-dependent reductions in CHT function [8].
  • To gain further insights into the cholinergic differentiation of presynaptic efferent terminals in the inner ear, we investigated the expression of the high-affinity choline transporter (ChT1) in comparison to other presynaptic and cholinergic markers [10].

Associations of Slc5a7 with chemical compounds


Other interactions of Slc5a7


Analytical, diagnostic and therapeutic context of Slc5a7


  1. The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice. Bazalakova, M.H., Blakely, R.D. Handbook of experimental pharmacology. (2006) [Pubmed]
  2. The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner. Matthies, D.S., Fleming, P.A., Wilkes, D.M., Blakely, R.D. J. Neurosci. (2006) [Pubmed]
  3. Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody. Bales, K.R., Tzavara, E.T., Wu, S., Wade, M.R., Bymaster, F.P., Paul, S.M., Nomikos, G.G. J. Clin. Invest. (2006) [Pubmed]
  4. Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. Ferguson, S.M., Bazalakova, M., Savchenko, V., Tapia, J.C., Wright, J., Blakely, R.D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. The neuronal choline transporter CHT1 is regulated by immunosuppressor-sensitive pathways. Guermonprez, L., O'Regan, S., Meunier, F.M., Morot-Gaudry-Talarmain, Y. J. Neurochem. (2002) [Pubmed]
  6. Reduced expression and capacity of the striatal high-affinity choline transporter in hyperdopaminergic mice. Parikh, V., Apparsundaram, S., Kozak, R., Richards, J.B., Sarter, M. Neuroscience (2006) [Pubmed]
  7. Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro. Berse, B., Szczecinska, W., Lopez-Coviella, I., Madziar, B., Zemelko, V., Kaminski, R., Kozar, K., Lips, K.S., Pfeil, U., Blusztajn, J.K. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  8. Regulation of choline transporter surface expression and phosphorylation by protein kinase C and protein phosphatase 1/2A. Gates, J., Ferguson, S.M., Blakely, R.D., Apparsundaram, S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  9. Distribution of high affinity choline transporter immunoreactivity in the primate central nervous system. Kus, L., Borys, E., Ping Chu, Y., Ferguson, S.M., Blakely, R.D., Emborg, M.E., Kordower, J.H., Levey, A.I., Mufson, E.J. J. Comp. Neurol. (2003) [Pubmed]
  10. The final stage of cholinergic differentiation occurs below inner hair cells during development of the rodent cochlea. Bergeron, A.L., Schrader, A., Yang, D., Osman, A.A., Simmons, D.D. J. Assoc. Res. Otolaryngol. (2005) [Pubmed]
  11. Localization of cholinergic innervation and neurturin receptors in adult mouse heart and expression of the neurturin gene. Mabe, A.M., Hoard, J.L., Duffourc, M.M., Hoover, D.B. Cell Tissue Res. (2006) [Pubmed]
  12. Molecular cloning and characterization of a murine hemicholinium-3-sensitive choline transporter. Apparsundaram, S., Ferguson, S.M., Blakely, R.D. Biochem. Soc. Trans. (2001) [Pubmed]
WikiGenes - Universities