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Chemical Compound Review

Xarlin     2-[2-[4-[(R)-(4- chlorophenyl)-phenyl...

Synonyms: Xyzall, Zirtec, Xusal, Levocetirizine, SureCN4914, ...
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Disease relevance of Levocetirizine


Psychiatry related information on Levocetirizine


High impact information on Levocetirizine

  • Levocetirizine has pharmacodynamically and pharmacokinetically favourable characteristics, including high bioavailability, rapid onset of action, limited distribution and a low degree of metabolism [8].
  • Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years [9].
  • RESULTS: In children aged 8.6 +/- 0.4 years (+/- SEM), the peak levocetirizine concentration was 450 +/- 37 ng/mL, and the time at which peak concentrations occurred was 1.2 +/- 0.2 hours [9].
  • Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis [1].
  • Binding kinetics provided a suitable explanation for this observation, because levocetirizine dissociated from H(1) receptors with a half-time of 142 min; that of (S)-cetirizine was only 6 min, implying that the former could act as a pseudo-irreversible antagonist in functional studies [10].

Chemical compound and disease context of Levocetirizine


Biological context of Levocetirizine


Anatomical context of Levocetirizine


Associations of Levocetirizine with other chemical compounds


Gene context of Levocetirizine


Analytical, diagnostic and therapeutic context of Levocetirizine


  1. Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. Bachert, C., Bousquet, J., Canonica, G.W., Durham, S.R., Klimek, L., Mullol, J., Van Cauwenberge, P.B., Van Hammée, G. J. Allergy Clin. Immunol. (2004) [Pubmed]
  2. Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies. Hair, P.I., Scott, L.J. Drugs (2006) [Pubmed]
  3. Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. Patou, J., De Smedt, H., van Cauwenberge, P., Bachert, C. Clin. Exp. Allergy (2006) [Pubmed]
  4. Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study. Ciprandi, G., Cirillo, I., Vizzaccaro, A., Tosca, M.A. Clin. Exp. Allergy (2004) [Pubmed]
  5. Levocetirizine for treatment of immediate and delayed mosquito bite reactions. Karppinen, A., Brummer-Korvenkontio, H., Petman, L., Kautiainen, H., Hervé, J.P., Reunala, T. Acta Derm. Venereol. (2006) [Pubmed]
  6. Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. Verster, J.C., Volkerts, E.R., van Oosterwijck, A.W., Aarab, M., Bijtjes, S.I., De Weert, A.M., Eijken, E.J., Verbaten, M.N. J. Allergy Clin. Immunol. (2003) [Pubmed]
  7. Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers. Gandon, J.M., Allain, H. British journal of clinical pharmacology. (2002) [Pubmed]
  8. Levocetirizine: an update. Walsh, G.M. Current medicinal chemistry. (2006) [Pubmed]
  9. Levocetirizine: pharmacokinetics and pharmacodynamics in children age 6 to 11 years. Simons, F.E., Simons, K.J. J. Allergy Clin. Immunol. (2005) [Pubmed]
  10. Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194). Gillard, M., Van Der Perren, C., Moguilevsky, N., Massingham, R., Chatelain, P. Mol. Pharmacol. (2002) [Pubmed]
  11. Comparative efficacy of cetirizine and levocetirizine in chronic idiopathic urticaria. Garg, G., Thami, G.P. The Journal of dermatological treatment (2007) [Pubmed]
  12. Comparison of the Risk of Drowsiness and Sedation between Levocetirizine and Desloratadine : A Prescription-Event Monitoring Study in England. Layton, D., Wilton, L., Boshier, A., Cornelius, V., Harris, S., Shakir, S.A. Drug safety : an international journal of medical toxicology and drug experience. (2006) [Pubmed]
  13. Evaluation of the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients by rhinoscintigraphy. Seven, B., Yoruk, O., Varoglu, E., Sutbeyaz, Y. Nuclear medicine communications (2007) [Pubmed]
  14. A direct comparison of the efficacy of antihistamines in SAR and PAR: randomised, placebo-controlled studies with levocetirizine and loratadine using an environmental exposure unit - the Vienna Challenge Chamber (VCC). Stübner, P., Zieglmayer, R., Horak, F. Current medical research and opinion. (2004) [Pubmed]
  15. Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers. Benedetti, M.S., Plisnier, M., Kaise, J., Maier, L., Baltes, E., Arendt, C., McCracken, N. Eur. J. Clin. Pharmacol. (2001) [Pubmed]
  16. Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers. Baltes, E., Coupez, R., Giezek, H., Voss, G., Meyerhoff, C., Strolin Benedetti, M. Fundamental & clinical pharmacology. (2001) [Pubmed]
  17. A new antihistamine levocetirizine inhibits eosinophil adhesion to vascular cell adhesion molecule-1 under flow conditions. Wu, P., Mitchell, S., Walsh, G.M. Clin. Exp. Allergy (2005) [Pubmed]
  18. Cetirizine and levocetirizine inhibit eotaxin-induced eosinophil transendothelial migration through human dermal or lung microvascular endothelial cells. Thomson, L., Blaylock, M.G., Sexton, D.W., Campbell, A., Walsh, G.M. Clin. Exp. Allergy (2002) [Pubmed]
  19. Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin. Clough, G.F., Boutsiouki, P., Church, M.K. Allergy (2001) [Pubmed]
  20. Facial thermography is a sensitive tool to determine antihistaminic activity: comparison of levocetirizine and fexofenadine. Larbig, M., Burtin, B., Martin, L., Stamm, H., Luettig, B., Hohlfeld, J.M., Krug, N. British journal of clinical pharmacology. (2006) [Pubmed]
  21. Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. Gillard, M., Chatelain, P. Eur. J. Pharmacol. (2006) [Pubmed]
  22. Pharmacological management of allergic rhinitis in the elderly: safety issues with oral antihistamines. Hansen, J., Klimek, L., Hörmann, K. Drugs & aging. (2005) [Pubmed]
  23. Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment. Caproni, M., Volpi, W., Giomi, B., Torchia, D., Del Bianco, E., Fabbri, P. Br. J. Dermatol. (2006) [Pubmed]
  24. Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans. Molimard, M., Diquet, B., Benedetti, M.S. Fundamental & clinical pharmacology. (2004) [Pubmed]
  25. Single and short-term dosing effects of levocetirizine on adenosine monophosphate bronchoprovocation in atopic asthma. Lee, D.K., Gray, R.D., Wilson, A.M., Robb, F.M., Soutar, P.C., Lipworth, B.J. British journal of clinical pharmacology. (2004) [Pubmed]
  26. Levocetirizine better protects than desloratadine in a nasal provocation with allergen. Deruaz, C., Leimgruber, A., Berney, M., Pradervand, E., Spertini, F. J. Allergy Clin. Immunol. (2004) [Pubmed]
  27. Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites. Potter, P.C. Allergy (2003) [Pubmed]
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