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MeSH Review:

Lymphoma, AIDS-Related

Tulpule, A., Breen, E.C. et al., Bacchi, C.E. et al., Loomis, R. et al., Levine, A.M. et al., et al.

Tulpule, Sherrod, Dharmapala, Young, Espina, Sanchez, Gill, Levine, Tulpule, Gaidano, Capello, Gloghini, Pastore, Migliazza, Quattrone, Savinelli, Buonaiuto, Cilia, Perin, Pasqualucci, Canzonieri, Saglio, Dalla-Favera, Carbone, Krishnan, Zaia, Molina, Breen, Boscardin, Detels, Jacobson, Smith, O'Brien, Chmiel, Rinaldo, Lai, Martínez-Maza, Reddy, Parsons, Mak, Chan,

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Disease relevance of Lymphoma, AIDS-Related

CONCLUSIONS.--Low-dose chemotherapy with central nervous system prophylaxis and zidovudine maintenance may be associated with durable remissions in AIDS-related lymphoma with fewer opportunistic infections than noted in prior reports [1].
The latent EBV nuclear antigen (EBNA-1) transcripts detected in the HIV-related lymphomas were characteristic of the pattern found in Burkitt lymphoma (g1 EBNA1) and not in transplant-related lymphoproliferations [2].
Bcl-2 is up-regulated by EBV in immortalized lymphoblastoid B cells and is expressed in the majority of EBV-associated lymphoproliferative diseases, including posttransplant lymphoproliferative disorder (PTLD) and AIDS-related lymphoma (ARL) [3].
Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma [4].
Simian AIDS-related lymphoma growth in severe combined immunodeficiency mice is independent of karyotypic abnormalities or Bcl-6 mutations [5].

High impact information on Lymphoma, AIDS-Related

These data suggest an autocrine growth mechanism for IL-10 in AIDS-related lymphoma cells and that IL-10 may be important in its pathogenesis [6].
Mitoguazone therapy in patients with refractory or relapsed AIDS-related lymphoma: results from a multicenter phase II trial [7].
Mutation of threonine 58, frequently found in retroviral v-Myc proteins and in human Burkitt and AIDS-related lymphomas, is associated with enhanced transforming activity and tumorigenicity [8].
Tat-mediated induction of beta-pol may alter DNA stability in AIDS-related lymphomas [9].
Finally, the anti-proliferative and apoptotic effects of LMP-1 antisense treatment were observed not only in laboratory-derived LCLs, but also in an EBV-positive cell line derived from an AIDS-related lymphoma [10].

Chemical compound and disease context of Lymphoma, AIDS-Related

Formalin-fixed, paraffin-embedded tissue from 24 cases of AIDS-related lymphoma in Brazil were analyzed for morphologic classification, immunophenotype, and EBV association using in situ hybridization studies with an EBV-EBER1 biotinylated probe [11].
2) Mutations and/or replacements predominated in CDR regions, which might suggest the occurrence of an antigen driven selection process, at least in some AIDS associated lymphomas [12].
Selected patients with HIV-related lymphoma can tolerate the high dose CBV myeloablative chemotherapy regimen without increased acute regimen-related toxicity [13].
Twenty patients with biopsy-proven AIDS-related lymphoma were treated with three 6-week cycles of oral chemotherapy consisting of lomustine (CCNU) 100 mg/m2 on day 1, cycles no [14].
An infusional regimen called EPOCH (etoposide, prednisone, vincristine [Oncovin], cyclophosphamide, doxorubicin HCl) shows promise in the future management of AIDS-related lymphoma [15].

Biological context of Lymphoma, AIDS-Related

An hsr on chromosome 7 was shown to be an insertion of four copies of the 11q23 MLL gene region in an HIV-related lymphoma [16].
Expression of the oncogene LMP (latent membrane protein) is seen in Sternberg-Reed (SR) cells and immunoblasts of AIDS-related lymphoma and infectious mononucleosis (IM) [17].
Liposomal encapsulation of doxorubicin when substituted for doxorubicin in the CHOP regimen (cyclophosphamide, doxorubicin, vincristine, prednisone) seems to overcome P-glycoprotein-mediated drug resistance in AIDS-related lymphoma [18].

Gene context of Lymphoma, AIDS-Related

In this study we examined 21 cases of AIDS-related lymphomas for genomic organization and expression of RB2/p130 oncosuppressor gene and compared the results with the proliferative features of these neoplasms [19].
Utilizing specimens from the Multicenter AIDS Cohort Study (MACS) obtained prior to diagnosis of AIDS-associated lymphoma, detectable serum human IL10 was seen much more frequently in lymphoma cases (n = 61, 26%) compared to CD4-matched AIDS controls (5%, P = 0.004), or to HIV-infected (2%, P = 0.002) or HIV uninfected subjects (0%, P = 0.0003) [20].
Likewise, while c-myc activation has been described in certain types of HIV-related lymphomas, c-myc dysregulation has not been reported in association with organ transplantation [21].
Multidrug resistance (MDR-1) expression in AIDS-related lymphomas [22].
BCL-6 in aids-related lymphomas: pathogenetic and histogenetic implications [23].

Analytical, diagnostic and therapeutic context of Lymphoma, AIDS-Related

Stem cell transplantation and gene therapy for HIV-related lymphomas [24].
MDR-1 expression in AIDS-related lymphoma is associated with poor response to conventional combination chemotherapy [18].

References

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