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Gene Review

CD27  -  CD27 molecule

Homo sapiens

Synonyms: CD27 antigen, CD27L receptor, S152, T-cell activation antigen CD27, T14, ...
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Disease relevance of CD27


Psychiatry related information on CD27


High impact information on CD27

  • CD27 is a surface antigen found on T and B cells that has homology to a family of molecules including the receptors for tumor necrosis factor (TNF) and nerve growth factor [8].
  • Here we present detailed studies of the differentiation phenotype of these cells, which can be separated into three distinct subsets based on expression of the costimulatory receptors CD28 and CD27 [9].
  • Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions [10].
  • T cell changes depended on continuous CD27-CD70 interactions and T cell antigen receptor stimulation [10].
  • DNMAML attenuated the pre-TCR-associated increase in cell size and CD27 expression [11].

Chemical compound and disease context of CD27


Biological context of CD27


Anatomical context of CD27


Associations of CD27 with chemical compounds


Physical interactions of CD27

  • Here we report that CD70, a cytokine overexpressed in RCC, promotes lymphocyte apoptosis through interaction with its receptor CD27 and with the intracellular receptor-binding protein SIVA [28].
  • Membrane expression of CD27 strongly increases after T cell activation via the TCR/CD3 complex or the CD2 molecule [27].

Regulatory relationships of CD27


Other interactions of CD27

  • The cloning of CD70 and its identification as the ligand for CD27 [33].
  • CD27 and CD40 clearly suppressed these processes [17].
  • The analysis of the expression of these molecules in the subsets classified by the combination of the expression of CCR7 and CD45RA or by that of CD27, CD28, and CD45RA showed that functional CD8(+) T cell subsets could be partially identified by these phenotypic classifications [34].
  • CD27 belongs to TNF receptor family, and it is unique in this family for its disulfide-linked homodimerization of 55-kDa monomers [35].
  • CD27 and CD40 inhibit p53-independent mitochondrial pathways in apoptosis of B cells induced by B cell receptor ligation [17].

Analytical, diagnostic and therapeutic context of CD27


  1. CD27 and CD57 Expression Reveals Atypical Differentiation of Human Immunodeficiency Virus Type 1-Specific Memory CD8+ T Cells. Hoji, A., Connolly, N.C., Buchanan, W.G., Rinaldo, C.R. Clin. Vaccine Immunol. (2007) [Pubmed]
  2. Bacterial CpG induces hyper-IgM production in CD27(+) memory B cells in primary biliary cirrhosis. Kikuchi, K., Lian, Z.X., Yang, G.X., Ansari, A.A., Ikehara, S., Kaplan, M., Miyakawa, H., Coppel, R.L., Gershwin, M.E. Gastroenterology (2005) [Pubmed]
  3. Signaling through CD70 regulates B cell activation and IgG production. Arens, R., Nolte, M.A., Tesselaar, K., Heemskerk, B., Reedquist, K.A., van Lier, R.A., van Oers, M.H. J. Immunol. (2004) [Pubmed]
  4. Loss of memory (CD27) B lymphocytes in HIV-1 infection. De Milito, A., Mörch, C., Sönnerborg, A., Chiodi, F. AIDS (2001) [Pubmed]
  5. CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells. Dong, H.Y., Shahsafaei, A., Dorfman, D.M. Leuk. Lymphoma (2002) [Pubmed]
  6. Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma. Widney, D., Gundapp, G., Said, J.W., van der Meijden, M., Bonavida, B., Demidem, A., Trevisan, C., Taylor, J., Detels, R., Martínez-Maza, O. Clin. Immunol. (1999) [Pubmed]
  7. Low levels of specific T cell activation marker CD27 accompanied by elevated levels of markers for non-specific immune activation in the cerebrospinal fluid of patients with AIDS dementia complex. Portegies, P., Godfried, M.H., Hintzen, R.Q., Stam, J., van der Poll, T., Bakker, M., van Deventer, S.J., van Lier, R.A., Goudsmit, J. J. Neuroimmunol. (1993) [Pubmed]
  8. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. Goodwin, R.G., Alderson, M.R., Smith, C.A., Armitage, R.J., VandenBos, T., Jerzy, R., Tough, T.W., Schoenborn, M.A., Davis-Smith, T., Hennen, K. Cell (1993) [Pubmed]
  9. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Appay, V., Dunbar, P.R., Callan, M., Klenerman, P., Gillespie, G.M., Papagno, L., Ogg, G.S., King, A., Lechner, F., Spina, C.A., Little, S., Havlir, D.V., Richman, D.D., Gruener, N., Pape, G., Waters, A., Easterbrook, P., Salio, M., Cerundolo, V., McMichael, A.J., Rowland-Jones, S.L. Nat. Med. (2002) [Pubmed]
  10. Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Tesselaar, K., Arens, R., van Schijndel, G.M., Baars, P.A., van der Valk, M.A., Borst, J., van Oers, M.H., van Lier, R.A. Nat. Immunol. (2003) [Pubmed]
  11. The requirement for Notch signaling at the {beta}-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. Maillard, I., Tu, L., Sambandam, A., Yashiro-Ohtani, Y., Millholland, J., Keeshan, K., Shestova, O., Xu, L., Bhandoola, A., Pear, W.S. J. Exp. Med. (2006) [Pubmed]
  12. Serum soluble CD27, but not thymidine kinase, is an independent prognostic factor for outcome in indolent non-Hodgkin's lymphoma. Kok, M., Bonfrer, J.M., Korse, C.M., de Jong, D., Kersten, M.J. Tumour Biol. (2003) [Pubmed]
  13. Virus-induced polyclonal B cell activation improves protective CTL memory via retained CD27 expression on memory CTL. Matter, M., Mumprecht, S., Pinschewer, D.D., Pavelic, V., Yagita, H., Krautwald, S., Borst, J., Ochsenbein, A.F. Eur. J. Immunol. (2005) [Pubmed]
  14. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. Loe, D.W., Almquist, K.C., Deeley, R.G., Cole, S.P. J. Biol. Chem. (1996) [Pubmed]
  15. A globally disseminated M1 subclone of group A streptococci differs from other subclones by 70 kilobases of prophage DNA and capacity for high-frequency intracellular invasion. Cleary, P.P., LaPenta, D., Vessela, R., Lam, H., Cue, D. Infect. Immun. (1998) [Pubmed]
  16. Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27/CD70 interaction. Agematsu, K., Nagumo, H., Oguchi, Y., Nakazawa, T., Fukushima, K., Yasui, K., Ito, S., Kobata, T., Morimoto, C., Komiyama, A. Blood (1998) [Pubmed]
  17. CD27 and CD40 inhibit p53-independent mitochondrial pathways in apoptosis of B cells induced by B cell receptor ligation. Hase, H., Kanno, Y., Kojima, H., Morimoto, C., Okumura, K., Kobata, T. J. Biol. Chem. (2002) [Pubmed]
  18. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. Akiba, H., Nakano, H., Nishinaka, S., Shindo, M., Kobata, T., Atsuta, M., Morimoto, C., Ware, C.F., Malinin, N.L., Wallach, D., Yagita, H., Okumura, K. J. Biol. Chem. (1998) [Pubmed]
  19. Isolation and regional assignment of human chromosome 12p cDNAs. Baens, M., Aerssens, J., van Zand, K., Van den Berghe, H., Marynen, P. Genomics (1995) [Pubmed]
  20. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. Camerini, D., Walz, G., Loenen, W.A., Borst, J., Seed, B. J. Immunol. (1991) [Pubmed]
  21. Memory B cells and CD27. Agematsu, K. Histol. Histopathol. (2000) [Pubmed]
  22. High levels of serum soluble CD27 correlated with renal dysfunction. Nakatsuji, T. Clin. Exp. Med. (2003) [Pubmed]
  23. S152 (CD27). A modulating disulfide-linked T cell activation antigen. Bigler, R.D., Bushkin, Y., Chiorazzi, N. J. Immunol. (1988) [Pubmed]
  24. Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. van Lier, R.A., Borst, J., Vroom, T.M., Klein, H., Van Mourik, P., Zeijlemaker, W.P., Melief, C.J. J. Immunol. (1987) [Pubmed]
  25. CD27/CD70 interactions regulate T dependent B cell differentiation. Jacquot, S. Immunol. Res. (2000) [Pubmed]
  26. CD27 is a signal-transducing molecule involved in CD45RA+ naive T cell costimulation. Kobata, T., Agematsu, K., Kameoka, J., Schlossman, S.F., Morimoto, C. J. Immunol. (1994) [Pubmed]
  27. Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors. de Jong, R., Loenen, W.A., Brouwer, M., van Emmerik, L., de Vries, E.F., Borst, J., van Lier, R.A. J. Immunol. (1991) [Pubmed]
  28. Immune escape for renal cell carcinoma: CD70 mediates apoptosis in lymphocytes. Diegmann, J., Junker, K., Loncarevic, I.F., Michel, S., Schimmel, B., von Eggeling, F. Neoplasia (2006) [Pubmed]
  29. CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation. Carr, J.M., Carrasco, M.J., Thaventhiran, J.E., Bambrough, P.J., Kraman, M., Edwards, A.D., Al-Shamkhani, A., Fearon, D.T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Wischhusen, J., Jung, G., Radovanovic, I., Beier, C., Steinbach, J.P., Rimner, A., Huang, H., Schulz, J.B., Ohgaki, H., Aguzzi, A., Rammensee, H.G., Weller, M. Cancer Res. (2002) [Pubmed]
  31. Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway. Py, B., Slomianny, C., Auberger, P., Petit, P.X., Benichou, S. J. Immunol. (2004) [Pubmed]
  32. CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases. Guikema, J.E., Vellenga, E., Abdulahad, W.H., Hovenga, S., Bos, N.A. Br. J. Haematol. (2004) [Pubmed]
  33. The cloning of CD70 and its identification as the ligand for CD27. Bowman, M.R., Crimmins, M.A., Yetz-Aldape, J., Kriz, R., Kelleher, K., Herrmann, S. J. Immunol. (1994) [Pubmed]
  34. Three Memory Subsets of Human CD8+ T Cells Differently Expressing Three Cytolytic Effector Molecules. Takata, H., Takiguchi, M. J. Immunol. (2006) [Pubmed]
  35. NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27. Yamamoto, H., Kishimoto, T., Minamoto, S. J. Immunol. (1998) [Pubmed]
  36. CD27 but not CD70 and 4-1BB intragraft gene expression is a risk factor for acute cardiac allograft rejection in humans. Shulzhenko, N., Morgun, A., Chinellato, A.P., Rampim, G.F., Diniz, R.V., Almeida, D.R., Gerbase-DeLima, M. Transplant. Proc. (2002) [Pubmed]
  37. Microarray analysis of gene expression associated with extrapulmonary dissemination of tuberculosis. Kim, D.K., Park, G.M., Hwang, Y.I., Kim, H.J., Han, S.K., Shim, Y.S., Yim, J.J. Respirology (2006) [Pubmed]
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