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Gene Review

Bcl6  -  B cell leukemia/lymphoma 6

Mus musculus

Synonyms: B-cell lymphoma 6 protein homolog, Bcl-6, Bcl5
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Disease relevance of Bcl6


High impact information on Bcl6


Biological context of Bcl6


Anatomical context of Bcl6

  • Therefore, Bcl6 is essential for the differentiation of GC B cells [1].
  • Disruption of the Bcl6 gene results in an impaired germinal center formation [1].
  • To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6(-/-)RM) [1].
  • Although there is mounting evidence for the importance and necessity of Blimp-1 in plasma cell development, there is uncertainty as to the role it plays in B cell differentiation of B cell subsets and the way in which it may interact with other transcription factors such as Pax5 and Bcl6 during ASC differentiation [11].
  • Thus, Bcl6 may play a role as a stabilizer in protecting spermatocytes from apoptosis induced by stressors [9].

Other interactions of Bcl6

  • We showed here that Id2 and Bcl6, both of which inhibit IgE GLT and CSR, are not involved in this inhibitory pathway [12].
  • We have identified two intronic regions of mouse prdm1, the gene encoding B lymphocyte-induced maturation protein-1 (Blimp-1), which confer transcriptional repression in response to Bcl-6 [13].
  • We also summarize our recent studies on the regulation of Blimp-1, showing direct repression by Bcl-6 and providing evidence for activation by NF-kappaB following toll-like receptor signaling [14].
  • Since the activated form of p38 MAP kinase was detected in spermatocytes of adult Bcl6-/- mice, the germ cell apoptosis may be induced by stressors [9].
  • Furthermore, overexpression of Bcl6 or Bcl6(POZ-) (Bcl6 deleted with the BTB/POZ domain) induced apoptosis in NIH3T3 cells, and the apoptosis was inhibited by the addition of histone deacetylase inhibitor in the culture [15].

Analytical, diagnostic and therapeutic context of Bcl6


  1. Disruption of the Bcl6 gene results in an impaired germinal center formation. Fukuda, T., Yoshida, T., Okada, S., Hatano, M., Miki, T., Ishibashi, K., Okabe, S., Koseki, H., Hirosawa, S., Taniguchi, M., Miyasaka, N., Tokuhisa, T. J. Exp. Med. (1997) [Pubmed]
  2. The role of Bcl6 in mature cardiac myocytes. Yoshida, T., Fukuda, T., Hatano, M., Koseki, H., Okabe, S., Ishibashi, K., Kojima, S., Arima, M., Komuro, I., Ishii, G., Miki, T., Hirosawa, S., Miyasaka, N., Taniguchi, M., Ochiai, T., Isono, K., Tokuhisa, T. Cardiovasc. Res. (1999) [Pubmed]
  3. Simian AIDS-related lymphoma growth in severe combined immunodeficiency mice is independent of karyotypic abnormalities or Bcl-6 mutations. Castaños-Vélez, E., Heiden, T., Lindvall, C., Capello, D., Sandlund, A., Imreh, S., Blennow, E., Andersson, L.C., Gaidano, G., Nordenskjöld, M., Biberfeld, P. AIDS Res. Hum. Retroviruses (2002) [Pubmed]
  4. Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Toyama, H., Okada, S., Hatano, M., Takahashi, Y., Takeda, N., Ichii, H., Takemori, T., Kuroda, Y., Tokuhisa, T. Immunity (2002) [Pubmed]
  5. Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Ichii, H., Sakamoto, A., Hatano, M., Okada, S., Toyama, H., Taki, S., Arima, M., Kuroda, Y., Tokuhisa, T. Nat. Immunol. (2002) [Pubmed]
  6. BCL6 suppresses RhoA activity to alter macrophage morphology and motility. Pixley, F.J., Xiong, Y., Yu, R.Y., Sahai, E.A., Stanley, E.R., Ye, B.H. J. Cell. Sci. (2005) [Pubmed]
  7. A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. Kuwahara, K., Yoshida, M., Kondo, E., Sakata, A., Watanabe, Y., Abe, E., Kouno, Y., Tomiyasu, S., Fujimura, S., Tokuhisa, T., Kimura, H., Ezaki, T., Sakaguchi, N. Blood (2000) [Pubmed]
  8. BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Okabe, S., Fukuda, T., Ishibashi, K., Kojima, S., Okada, S., Hatano, M., Ebara, M., Saisho, H., Tokuhisa, T. Mol. Cell. Biol. (1998) [Pubmed]
  9. Testicular germ cell apoptosis in Bcl6-deficient mice. Kojima, S., Hatano, M., Okada, S., Fukuda, T., Toyama, Y., Yuasa, S., Ito, H., Tokuhisa, T. Development (2001) [Pubmed]
  10. A putative silencer element in the IL-5 gene recognized by Bcl6. Arima, M., Toyama, H., Ichii, H., Kojima, S., Okada, S., Hatano, M., Cheng, G., Kubo, M., Fukuda, T., Tokuhisa, T. J. Immunol. (2002) [Pubmed]
  11. Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene. Fairfax, K.A., Corcoran, L.M., Pridans, C., Huntington, N.D., Kallies, A., Nutt, S.L., Tarlinton, D.M. J. Immunol. (2007) [Pubmed]
  12. CpG inhibits IgE class switch recombination through suppression of NF kappa B activity, but not through Id2 or Bcl6. Kusunoki, T., Sugai, M., Gonda, H., Nambu, Y., Nagata-Nakajima, N., Katakai, T., Kusunoki, M., Sakamoto, A., Tokuhisa, T., Nakahata, T., Yokota, Y., Shimizu, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  13. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. Tunyaplin, C., Shaffer, A.L., Angelin-Duclos, C.D., Yu, X., Staudt, L.M., Calame, K.L. J. Immunol. (2004) [Pubmed]
  14. Regulatory events in early and late B-cell differentiation. Johnson, K., Shapiro-Shelef, M., Tunyaplin, C., Calame, K. Mol. Immunol. (2005) [Pubmed]
  15. A new functional domain of Bcl6 family that recruits histone deacetylases. Zhang, H., Okada, S., Hatano, M., Okabe, S., Tokuhisa, T. Biochim. Biophys. Acta (2001) [Pubmed]
  16. Bcl6 is a transcriptional repressor for the IL-18 gene. Takeda, N., Arima, M., Tsuruoka, N., Okada, S., Hatano, M., Sakamoto, A., Kohno, Y., Tokuhisa, T. J. Immunol. (2003) [Pubmed]
  17. Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. Ichii, H., Sakamoto, A., Kuroda, Y., Tokuhisa, T. J. Immunol. (2004) [Pubmed]
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