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MeSH Review

Theta Rhythm

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Psychiatry related information on Theta Rhythm


High impact information on Theta Rhythm

  • Here we show that mice harboring a phospholipase C (PLC)-beta1(-/-) mutation (PLC-beta1(-/-) mice) lack one subset of theta rhythms normally observed during urethane anesthesia, alert immobility, and passive whole-body rotation [2].
  • We show that a single burst of five pulses at 200 Hz given on the positive phase of tail pinch-triggered theta rhythm reliably induced LTP in the stratum radiatum of the hippocampus of urethane-anesthetized rats [3].
  • Effects of 5-HT3 receptor antagonism on hippocampal theta rhythm, memory, and LTP induction in the freely moving rat [4].
  • Unilateral fimbria lesions left theta rhythm and AChE staining essentially unaltered in ipsilateral DHPC and MEC but depleted AChE in ipsilateral ventral hippocampus (VHPC) and ventral lateral entorhinal cortex (LEC) [5].
  • A lesion of the dorsal fornix at the level of the hippocampal flexure left ipsilateral DHPC theta rhythm and AChE stain unaltered while causing a substantial reduction in theta rhythm and depletion of AChE in ipsilateral MEC [5].

Biological context of Theta Rhythm


Anatomical context of Theta Rhythm


Associations of Theta Rhythm with chemical compounds

  • These results suggest tha MSA paces MEC theta rhythm and that the presumed cholinergic projection which mediates this function travels in the dorsal fornix [5].
  • MEASUREMENTS AND RESULTS: In artificially ventilated rats, carbachol injections repeatedly elicited cortical activation and hippocampal theta rhythm [13].
  • These results suggest a role of interactions between NMDA conductance and intrinsic membrane properties in generating the CA1 theta-rhythm [14].
  • Hippocampal theta rhythm in behaving rats following ibotenic acid lesion of the septum [9].
  • A constant impulse flow in the septohippocampal GABA pathway is essential for the generation of theta rhythm [15].

Gene context of Theta Rhythm

  • However, in mice, inhibition of ERK activation blocked LTP induced by two LTP induction paradigms that mimicked the endogenous theta rhythm [16].
  • The pronounced theta rhythm characteristic of unanesthetized mocha mice was not observed in these chloral-hydrate anesthetized mice, whereas spike discharge activity was frequently present in the recordings [17].
  • A frontal midline theta rhythm increased in magnitude with increased memory load [18].
  • Intrahippocampal injection of NMDA receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV, 2.5 microg) decreased the amplitude of the theta rhythm and, less consistently, the gamma EEG [6].
  • Opposite effects of oxytocin and vasopressin on avoidance behaviour and hippocampal theta rhythm in the rat [19].

Analytical, diagnostic and therapeutic context of Theta Rhythm


  1. A direct nicotinic receptor-mediated inhibition recorded intracellularly in vitro. Wong, L.A., Gallagher, J.P. Nature (1989) [Pubmed]
  2. Genetic dissection of theta rhythm heterogeneity in mice. Shin, J., Kim, D., Bianchi, R., Wong, R.K., Shin, H.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can Be depotentiated by stimulation on the negative phase in area CA1 in vivo. Hölscher, C., Anwyl, R., Rowan, M.J. J. Neurosci. (1997) [Pubmed]
  4. Effects of 5-HT3 receptor antagonism on hippocampal theta rhythm, memory, and LTP induction in the freely moving rat. Stäubli, U., Xu, F.B. J. Neurosci. (1995) [Pubmed]
  5. Medial septal area lesions disrupt theta rhythm and cholinergic staining in medial entorhinal cortex and produce impaired radial arm maze behavior in rats. Mitchell, S.J., Rawlins, J.N., Steward, O., Olton, D.S. J. Neurosci. (1982) [Pubmed]
  6. Glutamatergic synaptic transmission participates in generating the hippocampal EEG. Leung, L.S., Shen, B. Hippocampus. (2004) [Pubmed]
  7. Differences in time course of ACh and GABA modulation of excitatory synaptic potentials in slices of rat hippocampus. Hasselmo, M.E., Fehlau, B.P. J. Neurophysiol. (2001) [Pubmed]
  8. Intracellular records of carbachol-induced theta rhythm in hippocampal slices. Bland, B.H., Colom, L.V., Konopacki, J., Roth, S.H. Brain Res. (1988) [Pubmed]
  9. Hippocampal theta rhythm in behaving rats following ibotenic acid lesion of the septum. Leung, L.S., Martin, L.A., Stewart, D.J. Hippocampus. (1994) [Pubmed]
  10. The supramammillary nucleus: is it necessary for the mediation of hippocampal theta rhythm? Thinschmidt, J.S., Kinney, G.G., Kocsis, B. Neuroscience (1995) [Pubmed]
  11. Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat. Vertes, R.P., Kinney, G.G., Kocsis, B., Fortin, W.J. Neuroscience (1994) [Pubmed]
  12. Distribution of polysialylated neural cell adhesion molecule in rat septal nuclei and septohippocampal pathway: transient increase of polysialylated interneurons in the subtriangular septal zone during memory consolidation. Foley, A.G., Rønn, L.C., Murphy, K.J., Regan, C.M. J. Neurosci. Res. (2003) [Pubmed]
  13. Carbachol injections into the ventral pontine reticular formation activate locus coeruleus cells in urethane-anesthetized rats. Fenik, V.B., Ogawa, H., Davies, R.O., Kubin, L. Sleep. (2005) [Pubmed]
  14. Cellular mechanisms underlying the rhythmic bursts induced by NMDA microiontophoresis at the apical dendrites of CA1 pyramidal neurons. Bonansco, C., Buño, W. Hippocampus. (2003) [Pubmed]
  15. Intrinsic vesicular glutamate transporter 2-immunoreactive input to septohippocampal parvalbumin-containing neurons: novel glutamatergic local circuit cells. Hajszan, T., Alreja, M., Leranth, C. Hippocampus. (2004) [Pubmed]
  16. A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. Selcher, J.C., Weeber, E.J., Christian, J., Nekrasova, T., Landreth, G.E., Sweatt, J.D. Learn. Mem. (2003) [Pubmed]
  17. Hippocampal auditory gating in the hyperactive mocha mouse. Miller, C.L., Burmeister, M., Stevens, K.E. Neurosci. Lett. (1999) [Pubmed]
  18. High-resolution EEG mapping of cortical activation related to working memory: effects of task difficulty, type of processing, and practice. Gevins, A., Smith, M.E., McEvoy, L., Yu, D. Cereb. Cortex (1997) [Pubmed]
  19. Opposite effects of oxytocin and vasopressin on avoidance behaviour and hippocampal theta rhythm in the rat. Bohus, B., Urban, I., van Wimersma Greidanus, T.B., de Wied, D. Neuropharmacology (1978) [Pubmed]
  20. Relationships of nucleus reticularis pontis oralis neuronal discharge with sensory and carbachol evoked hippocampal theta rhythm. Nuñez, A., de Andrés, I., García-Austt, E. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1991) [Pubmed]
  21. Brainstem carbachol injections in the urethane anesthetized rat produce hippocampal theta rhythm and cortical desynchronization: a comparison of pedunculopontine tegmental versus nucleus pontis oralis injections. Kinney, G.G., Vogel, G.W., Feng, P. Brain Res. (1998) [Pubmed]
  22. Hippocampal and entorhinal glucose metabolism in relation to cholinergic theta rhythm. Sánchez-Arroyos, R., Gaztelu, J.M., Zaplana, J., Dajas, F., García-Austt, E. Brain Res. Bull. (1993) [Pubmed]
  23. Frontal midline theta rhythm in young healthy adults. Takahashi, N., Shinomiya, S., Mori, D., Tachibana, S. Clinical EEG (electroencephalography). (1997) [Pubmed]
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