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MeSH Review

Septum of Brain

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Disease relevance of Septum of Brain


Psychiatry related information on Septum of Brain


High impact information on Septum of Brain

  • Two weeks later, the IL-3-treated animals showed significant numbers of acetylcholinesterase-positive neurons remaining in the septal region [11].
  • This finding was substantiated by a concomitant decrease of immunopositive staining for ChAT in the septal area [12].
  • Other prominent sites of CRF receptor mRNA expression include subcortical limbic structures in the septal region and amygdala [13].
  • In the septal region some bipolar neurons send both of their processes towards the ventricular surface [14].
  • Intraseptal CR neurons, which establish symmetric synapses, innervate only lateral septal area neurons, including the CB-containing cells [15].

Chemical compound and disease context of Septum of Brain


Biological context of Septum of Brain


Anatomical context of Septum of Brain


Associations of Septum of Brain with chemical compounds


Gene context of Septum of Brain

  • In this mutant, Egt2p was displaced from the septal region to the cell cortex, indicating that GPI7 plays an important role in cell separation via the GPI-based modification of daughter-specific proteins in S. cerevisiae [31].
  • In severely affected offspring, complete loss of the septal region resulted in conjoined lateral ventricles and a reduction in the thickness of the ventricular zone surrounding the single ventricle, as well as a severe loss of ChAT neurons which would normally be located in this territory [32].
  • In pregnant rats near term, the release of AVP was greater than that of virgin rats in both the ventral (p less than 0.001) and mediolateral (p less than 0.001) septal areas; similarly, release of OXT increased in the ventral septal area (p less than 0.01) at this time [33].
  • Both BDNF and NGF treatment completely prevent the lesion induced loss of p75NGFR-positive cells in the septal area of animals with fimbrial transections [34].
  • Expression of neurotrophins and the low-affinity NGF receptor in septal and hippocampal reaggregate cultures: local physiologic effects of NGF synthesized in the septal region [35].

Analytical, diagnostic and therapeutic context of Septum of Brain


  1. Stimulation of vasopressin release in the ventral septum of the rat brain suppresses prostaglandin E1 fever. Naylor, A.M., Pittman, Q.J., Veale, W.L. J. Physiol. (Lond.) (1988) [Pubmed]
  2. Differential and sex-specific effects of kainic acid and domoic acid lesions in the lateral septal area of rats on immune function and body weight regulation. Wetmore, L., Nance, D.M. Exp. Neurol. (1991) [Pubmed]
  3. On the role of the septal area in the development of DOCA-salt hypertension in the rat. Richardson, J.S. Clinical and experimental hypertension. Part A, Theory and practice. (1983) [Pubmed]
  4. Brain lesion-induced alteration of selected phenotypic properties of spleen macrophages and their partial restoration in the course of foreign body reaction against intraperitoneally implanted polymers. Smetana, K., Petrovický, P., Zach, P., Nemcová, V., Jelínková, M., Vacík, J., Gabius, H.J. Journal of materials science. Materials in medicine. (1999) [Pubmed]
  5. Isolated anomalous origin of right coronary artery from the main pulmonary artery. Yao, C.T., Wang, J.N., Yeh, C.N., Huang, S.C., Yang, Y.R., Wu, J.M. Journal of cardiac surgery. (2005) [Pubmed]
  6. Excitotoxic basolateral amygdala lesions potentiate the memory impairment effect of muscimol injected into the medial septal area. Spanis, C.W., Bianchin, M.M., Izquierdo, I., McGaugh, J.L. Brain Res. (1999) [Pubmed]
  7. Muscimol infused into the medial septal area impairs long-term memory but not short-term memory in inhibitory avoidance, water maze place learning and rewarded alternation tasks. Nagahara, A.H., McGaugh, J.L. Brain Res. (1992) [Pubmed]
  8. The osmotic component of ethanol and urea action is critical for their immediate stimulation of thyrotropin-releasing hormone (TRH) release from rat brain septum. Kucerová, J., Strbák, V. Physiological research / Academia Scientiarum Bohemoslovaca. (2001) [Pubmed]
  9. Naltrexone-sensitive behavioral actions of the ACTH 4-9 analog (Org 2766). Fekete, M., Drago, F., Van Ree, J.M., Bohus, B., Wiegant, V.M., De Wied, D. Life Sci. (1983) [Pubmed]
  10. Increased alcohol intake and behavioral disinhibition in rats with ventral striatal neuron loss. Johansson, A.K., Hansen, S. Physiol. Behav. (2000) [Pubmed]
  11. Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo. Kamegai, M., Niijima, K., Kunishita, T., Nishizawa, M., Ogawa, M., Araki, M., Ueki, A., Konishi, Y., Tabira, T. Neuron (1990) [Pubmed]
  12. Evidence for a physiological role of nerve growth factor in the central nervous system of neonatal rats. Vantini, G., Schiavo, N., Di Martino, A., Polato, P., Triban, C., Callegaro, L., Toffano, G., Leon, A. Neuron (1989) [Pubmed]
  13. Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Potter, E., Sutton, S., Donaldson, C., Chen, R., Perrin, M., Lewis, K., Sawchenko, P.E., Vale, W. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. Rich ependymal investment of luliberin (LHRH) fibers revealed immunocytochemically in an image like that from Golgi stain. Burchanowski, B.J., Knigge, K.M., Sternberger, L.A. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  15. A population of supramammillary area calretinin neurons terminating on medial septal area cholinergic and lateral septal area calbindin-containing cells are aspartate/glutamatergic. Leranth, C., Kiss, J. J. Neurosci. (1996) [Pubmed]
  16. Indomethacin-induced antipyresis in the rat: role of vasopressin receptors. Fyda, D.M., Cooper, K.E., Veale, W.L. Brain Res. (1989) [Pubmed]
  17. Effect of immobilization on in vitro thyrotropin-releasing hormone release from brain septum in wild-type and corticotropin-releasing hormone knock-out mice. Kiss, A., Adameová, A., Kubovcáková, L., Jamal, B., Bacová, Z., Zórad, S., Tybitanclová, K., Kvetnanský, R., Strbák, V. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  18. The septum: neural systems involved in eating, drinking, irritability, nuricide, copulation, and activity in rats. Paxinos, G. Journal of comparative and physiological psychology. (1975) [Pubmed]
  19. Central interleukin-1 beta stimulation of vasopressin release into the rat brain: activation of an antipyretic pathway. Wilkinson, M.F., Horn, T.F., Kasting, N.W., Pittman, Q.J. J. Physiol. (Lond.) (1994) [Pubmed]
  20. Subcellular localization and characterization of vasopressin binding sites in the ventral septal area, lateral septum, and hippocampus of the rat brain. Poulin, P., Lederis, K., Pittman, Q.J. J. Neurochem. (1988) [Pubmed]
  21. Pressor effects of acetylcholine injected into the lateral septal area of conscious rats. Peres-Polon, V.L., Corrêa, F.M. Neuropharmacology (1994) [Pubmed]
  22. Influence of chronic prenatal ethanol on cholinergic neurons of the septohippocampal system. Swanson, D.J., Tonjes, L., King, M.A., Walker, D.W., Heaton, M.B. J. Comp. Neurol. (1996) [Pubmed]
  23. Convergent vasopressinergic and hippocampal input onto somatospiny neurons of the rat lateral septal area. Jakab, R.L., Naftolin, F., Leranth, C. Neuroscience (1991) [Pubmed]
  24. Modulation of forebrain electroencephalographic activity in halothane-anesthetized rat via actions of noradrenergic beta-receptors within the medial septal region. Berridge, C.W., Bolen, S.J., Manley, M.S., Foote, S.L. J. Neurosci. (1996) [Pubmed]
  25. Septal arginine vasopressin (AVP) receptor regulation in rats depleted of septal AVP following long-term castration. Poulin, P., Pittman, Q.J. J. Neurosci. (1991) [Pubmed]
  26. Covariation of activity in habenula and dorsal raphé nuclei following tryptophan depletion. Morris, J.S., Smith, K.A., Cowen, P.J., Friston, K.J., Dolan, R.J. Neuroimage (1999) [Pubmed]
  27. V1-type vasopressin receptors in rat brain septum: binding characteristics and effects on inositol phospholipid metabolism. Shewey, L.M., Dorsa, D.M. J. Neurosci. (1988) [Pubmed]
  28. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. Hefti, F. J. Neurosci. (1986) [Pubmed]
  29. The central pressor effect of bradykinin in normotensive and hypertensive rats. Lindsey, C.J., Fujita, K., Martins, T.O. Hypertension (1988) [Pubmed]
  30. Plasticity in the rat hippocampal formation following ibotenic acid lesion of the septal region: a quantitative [14C]deoxyglucose and acetylcholinesterase study. Schulz, J.B., Wree, A., Schleicher, A., Zilles, K. J. Cereb. Blood Flow Metab. (1992) [Pubmed]
  31. GPI7 involved in glycosylphosphatidylinositol biosynthesis is essential for yeast cell separation. Fujita, M., Yoko-o, T., Okamoto, M., Jigami, Y. J. Biol. Chem. (2004) [Pubmed]
  32. Development of neurotransmitter systems in the mouse embryo following acute ethanol exposure: a histological and immunocytochemical study. Schambra, U.B., Lauder, J.M., Petrusz, P., Sulik, K.K. Int. J. Dev. Neurosci. (1990) [Pubmed]
  33. Septal and hippocampal release of vasopressin and oxytocin during late pregnancy and parturition in the rat. Landgraf, R., Neumann, I., Pittman, Q.J. Neuroendocrinology (1991) [Pubmed]
  34. BDNF protection of basal forebrain cholinergic neurons after axotomy: complete protection of p75NGFR-positive cells. Widmer, H.R., Knüsel, B., Hefti, F. Neuroreport (1993) [Pubmed]
  35. Expression of neurotrophins and the low-affinity NGF receptor in septal and hippocampal reaggregate cultures: local physiologic effects of NGF synthesized in the septal region. Roback, J.D., Diede, S.J., Downen, M., Lee, H.J., Kwon, J., Large, T.H., Otten, U., Wainer, B.H. Brain Res. Dev. Brain Res. (1992) [Pubmed]
  36. Localization of surface immunogenic protein on group B streptococcus. Rioux, S., Martin, D., Ackermann, H.W., Dumont, J., Hamel, J., Brodeur, B.R. Infect. Immun. (2001) [Pubmed]
  37. The lateral septal area is involved in the pressor pathway activated by microinjection of norepinephrine into the rat brain cingulate cortex. Fernandes, K.B., Tavares, R.F., Corrêa, F.M. Neuropharmacology (2005) [Pubmed]
  38. Presenilin 1 is essential for cardiac morphogenesis. Nakajima, M., Moriizumi, E., Koseki, H., Shirasawa, T. Dev. Dyn. (2004) [Pubmed]
  39. Perfusion of the septum of the rabbit with vasopressin antiserum enhances endotoxin fever. Malkinson, T.J., Bridges, T.E., Lederis, K., Veale, W.L. Peptides (1987) [Pubmed]
  40. Differential involvement of the lateral and medial divisions of the septal area on spatial learning processes as revealed by intracranial self-administration of morphine in mice. Cazala, P., Norena, A., Le Merrer, J., Galey, D. Behav. Brain Res. (1998) [Pubmed]
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