Disease relevance of Placenta Accreta

• Taken together these findings suggest that CRH inhibits trophoblast invasion by decreasing the expression of CEACAM1 through CRHR1, an effect that might be involved in the pathophysiology of clinical conditions, such as preeclampsia and placenta accreta [1].
• Placenta previa, placenta accreta, and vasa previa [2].
• Uterine inversion secondary to placenta accreta in a diethylstilbestrol-exposed parturient. A case report [3].
• A case of transient myocardial ischemia following subendometrial vasopressin infiltration in intractable intra-operative postpartum bleeding due to placenta accreta is described [4].

High impact information on Placenta Accreta

• Gadolinium-enhanced MR imaging in the differential diagnosis of placenta accreta and placenta percreta [5].
• Normal placenta (first-trimester as well as full-term), placenta from tubal pregnancy and placenta accreta were all found to express TrPM antigens [6].
• Differential expression of vascular endothelial growth factor, placenta growth factor and their receptors in placentae from pregnancies complicated by placenta accreta [7].
• These observations suggest that the participation of up-regulated VEGF and down-regulated VEGFR-2 (both membrane-bound and soluble forms) may be associated with the development of placenta accreta [7].
• BACKGROUND: Control of bleeding is the goal of management for placenta accreta, which usually necessitates hysterectomy [8].

Chemical compound and disease context of Placenta Accreta

• Effects of methotrexate treatment in placenta percreta with urinary bladder wall invasion [9].
• CONCLUSION: Argon beam coagulation may successfully help manage placenta percreta with bladder invasion while minimizing blood loss [10].
• Creatine kinase as a biochemical marker in diagnosis of placenta increta and percreta [11].
• Intractable postpartum bleeding due to placenta accreta: local vasopressin may save the uterus [12].
• Transverse fundal uterine incision in a patient with placenta increta [13].

Biological context of Placenta Accreta

• This case of placenta percreta diagnosed in the second trimester was associated with an elevated maternal serum alpha-fetoprotein level [14].
• CASE: A 33-year-old woman, gravida 2 para 1, with placenta accreta was treated with the Argon beam coagulator, and hemostasis was achieved in the lower uterine segment [15].

Anatomical context of Placenta Accreta

• In a case of placenta accreta (which develops without decidua basalis and is therefore adherent to the underlying myometrium), HLA-G mRNA and protein were also expressed [16].
• Differential expression of angiopoietin-1, angiopoietin-2, and Tie receptors in placentas from pregnancies complicated by placenta accreta [17].

Gene context of Placenta Accreta

• CONCLUSION: These observations suggest that the participation of up-regulated angiopoietin-2 and down-regulated Tie-2 in the placental tissues may indicate a role for these angiogenic factors in the development of placenta accreta [17].
• OBJECTIVE: The purpose of this study was to investigate the differential expression of angiopoietin-1, angiopoietin-2, and Tie receptors (Tie-1 and Tie-2) in placentas from pregnancies complicated by placenta accreta [17].
• Placenta accreta is associated with elevated maternal serum alpha-fetoprotein [18].
• In an effort to determine if a changing clinical picture for placenta accreta exists in the late 1970s, 22 cases from January 1, 1975, to May 30, 1979, at Los Angeles County/University of Southern California (LAC/USC) Medical Center were reviewed [19].
• MATERIAL AND METHODS: Five patients underwent MRI with HASTE (n = 5) and/or True FISP (n = 4) sequences for suspected placenta accreta [20].

Analytical, diagnostic and therapeutic context of Placenta Accreta

• Failure of methotrexate and internal iliac balloon catheterization to manage placenta percreta [21].
• We describe two cases which demonstrate methotrexate (mtx) to be an effective alternative to surgery in two serious complications of early pregnancy, namely placenta accreta diagnosed at attempted evacuation of retained products of conception and interstitial cornual pregnancy diagnosed at laparoscopy [22].
• We reviewed all published reports and articles regarding the clinical and surgical management of placenta percreta and nontraditional ways to treat or prevent anemia in these cases (including acute normovolemic hemodilution and erythropoietin use) [23].
• Enzyme-linked immunosorbent assay in the placental lysates showed that women with placenta accreta demonstrated significantly higher angiopoietin-2 and lower Tie-2 concentrations than did women with normal pregnancies (P = .026 and .003, respectively) [17].

References