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MeSH Review

Muscle Hypertonia

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Disease relevance of Muscle Hypertonia


High impact information on Muscle Hypertonia

  • Hereditary hyperekplexia, an autosomal dominant neurologic disorder characterized by an exaggerated startle reflex and neonatal hypertonia, can be caused by mutations in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor (GLRA1) [6].
  • The increased muscle tone was not reduced by subcutaneous administration of apomorphine, despite the presence of a normal population of striatal dopamine receptors [7].
  • Microinjection of non-NMDA agonists into peri-locus coeruleus alpha (peri-LC alpha) and nucleus magnocellularis (NMC) suppressed muscle tone, while injection of NMDA agonists at the same sites increased muscle tone and produced locomotion [8].
  • The increased muscle tone and extrajunctional AChR suggest and altered neural influence, but the markedly increased creatine phosphokinase activity is more characteristic of muscle damage [9].
  • RESULTS: No disturbances in neurologic function were detected in either animal species. intrathecal adenosine caused transient sedation in rats and increased muscle tone in dogs, resolving with continued exposure to drug [10].

Chemical compound and disease context of Muscle Hypertonia


Anatomical context of Muscle Hypertonia


Gene context of Muscle Hypertonia


Analytical, diagnostic and therapeutic context of Muscle Hypertonia


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