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MeSH Review

Thoracic Cavity

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Disease relevance of Thoracic Cavity


High impact information on Thoracic Cavity

  • H226 cells transfected with either sense VEGF 165 or sense VEGF 121 genes induced localized vascular hyperpermeability and produced PE only after direct implantation into the thoracic cavity [6].
  • Xenon-133 ventilation images showed both rapid entry into and later washout of activity from the air-filled portion of the right thoracic cavity [7].
  • After vehicle, 2 mg x kg(-1) x day(-1) simvastatin, 2 mg x kg(-1) x day(-1) atorvastatin, or 4 mg x kg(-1) x day(-1) pravastatin were administered orally for 6 days, the thoracic cavity was opened, and the heart was removed under pentobarbital sodium (30 mg/kg ip) anesthesia [8].
  • In contrast to heparin, effective antithrombotic doses of activated site-blocked factor IXa significantly diminished blood loss in the thoracic cavity and in an abdominal incisional bleeding model [9].
  • Adenosine triphosphate at a concentration of 10(-4) mol/L significantly reduces the blood volume (p < 0.005) oozed from the thoracic cavity of the patients (mean, 288 +/- 188 mL) when compared with controls (mean, 564 +/- 288 mL) [10].

Chemical compound and disease context of Thoracic Cavity


Biological context of Thoracic Cavity


Anatomical context of Thoracic Cavity

  • Fatty acid analysis of cell populations isolated from he spleen, thymus, thoracic cavity and peripheral blood phospholipids showed increases in omega 3 fatty acids accompanied by decreases in the omega 6 fatty acids when diets high in alpha-linolenic to linoleic acid ratios were fed [15].
  • Tumor necrosis factor-alpha, a major neutrophil-activating cytokine expressed by macrophages in the thoracic cavity around the worms, was highly induced in wild-type but absent in KO mice [16].
  • Neutrophils, which we showed earlier to be essential for the encapsulation process in the thoracic cavity, where the worms reside, were diminished at this location in IFN-gamma KO compared to wild-type mice; they also displayed strongly reduced chemotactic and phagocytic activity compared to neutrophils of controls [16].
  • RESULTS: Median serum cTnT in samples from the thoracic cavity of C57BL/6J mice was about 20-90 times higher, and from ApoE/LDLr KO mice about 30 times higher than serum cTnT in samples from the external jugular vein [17].
  • Drains were placed in the anterior mediastinum, left thoracic cavity, and abscess cavity, and another drain was placed in the mediastinal space for continuous cleansing with povidone iodine, oxydol [18].

Associations of Thoracic Cavity with chemical compounds

  • We measured the volume change of the thoracic cavity (delta Vth) and the volumes displaced by the diaphragm (delta Vdi) and rib cage (delta Vrc) in six pentobarbital-anesthetized dogs lying supine [19].
  • Effect of an intrathoracic injection of sodium hyaluronic acid on the prevention of pleural thickening in excess fluid of tuberculous thoracic cavity [20].
  • No pathologic changes were detected despite a total of 3400 mg phenol delivered into the right thoracic cavity [21].
  • Following complete drainage of the thoracic cavity under ultrasound guidance, 180 mg/m2 carboplatin diluted in 60 ml sterile water was infused into the pleural space (30 ml in each hemithorax) [22].
  • A gallium scintigram demonstrated an abnormal uptake in the thoracic cavity, liver, and bones [23].

Gene context of Thoracic Cavity

  • Also, administration of LcS has been shown to induce the production of several cytokines, such as IFN-gamma, IL-1beta and TNF-alpha, in the thoracic cavity of mice, resulting in the inhibition of tumour growth and increased survival [24].
  • The smaller-than-normal thoracic cavity observed in the cmd mutant, imposing a significant restriction on the developing lungs, is the most likely mechanism of pulmonary hypoplasia in this form of chondrodystrophy-confirming that reported for the cho mouse mutant [25].
  • Inoculation of Meth A cells into the thoracic cavity of BALB/c mice caused growth of the cells and the mice died from the tumor with an increased amount of pleural fluid [26].
  • End-expiratory thoracic cavity volume (Vthx) was measured in eight volunteers lying supine by three-dimensional X-ray computed tomography using the Dynamic Spatial Reconstructor [27].
  • These data suggest a strong association between right thoracotomies for ASD repairs and PND, especially in the female pubescent group when a low submammary skin incision (seventh to eighth space) is used with a fifth to sixth space entry into the thoracic cavity [28].

Analytical, diagnostic and therapeutic context of Thoracic Cavity

  • The selective presence of atropine was attributed to its possible administration into the thoracic cavity by the emergency medical personnel at the accident site for resuscitation, but circulatory failure prevented its further distribution [29].
  • Thoracoscopy also proved effective in the curative surgical procedure, i.e. resection of the abscess wall as far as possible, debridement of the remaining wall, irrigation, and instillation of streptomycin into the abscess and thoracic cavity [30].


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  2. The role of tumor necrosis factor (TNF)-alpha in the antitumor effect of intrapleural injection of Lactobacillus casei strain Shirota in mice. Yasutake, N., Matsuzaki, T., Kimura, K., Hashimoto, S., Yokokura, T., Yoshikai, Y. Med. Microbiol. Immunol. (Berl.) (1999) [Pubmed]
  3. Thoracic complications of amebiasis. Del Campo, C., Del Campo, M. Canadian journal of surgery. Journal canadien de chirurgie. (1982) [Pubmed]
  4. Perforating appendicitis within a diaphragmatic hernia: a case report. Gürses, N., Gürses, N. Zeitschrift für Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft für Kinderchirurgie = Surgery in infancy and childhood. (1986) [Pubmed]
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  6. Production of experimental malignant pleural effusions is dependent on invasion of the pleura and expression of vascular endothelial growth factor/vascular permeability factor by human lung cancer cells. Yano, S., Shinohara, H., Herbst, R.S., Kuniyasu, H., Bucana, C.D., Ellis, L.M., Fidler, I.J. Am. J. Pathol. (2000) [Pubmed]
  7. Open bronchial stump post-pneumonectomy: findings on xenon-133 ventilation imaging. Jacobson, A.F., Herzog, S.A. J. Nucl. Med. (1993) [Pubmed]
  8. Limitation of heart growth in neonatal piglets by simvastatin and atorvastatin: comparison with pravastatin. Satoh, K., Shirota, F., Tsunajima, T., Beinlich, C.J., Morgan, H.E., Ichihara, K. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  9. Heparinless cardiopulmonary bypass with active-site blocked factor IXa: a preliminary study on the dog. Spanier, T.B., Oz, M.C., Minanov, O.P., Simantov, R., Kisiel, W., Stern, D.M., Rose, E.A., Schmidt, A.M. J. Thorac. Cardiovasc. Surg. (1998) [Pubmed]
  10. ATP reduces blood loss produced by heparin in cardiopulmonary bypass operations. Garcia, H.V., Buffolo, E., Nader, H.B., Dietrich, C.P. Ann. Thorac. Surg. (1994) [Pubmed]
  11. Evaluation of left parasternal approach for cardiac surgery. Wang, W.L., Zeng, W.S., Cai, K.C., Jiang, R.C., Zhong, S.Z., Wang, W.J. Di Yi Jun Yi Da Xue Xue Bao (2002) [Pubmed]
  12. Intrapleural analgesia following thoracoscopic sympathectomy for palmar hyperhidrosis: a prospective, randomized trial. Assalia, A., Kopelman, D., Markovits, R., Hashmonai, M. Surgical endoscopy. (2003) [Pubmed]
  13. Experimental study on postmortem formation of carbon monoxide. Kojima, T., Yashiki, M., Une, I. Forensic Sci. Int. (1983) [Pubmed]
  14. Effects of furosemide and slow-release furosemide on thoracic fluid volumes. Brodin, L.A., Jogestrand, T., Larsen, F.F., Tedner, B., Walldius, G. Clinical cardiology. (1986) [Pubmed]
  15. The effect of dietary alpha-linolenic acid in the rat on fatty acid profiles of immunocompetent cell populations. Marshall, L.A., Johnston, P.V. Lipids (1983) [Pubmed]
  16. Lack of interferon-gamma confers impaired neutrophil granulocyte function and imparts prolonged survival of adult filarial worms in murine filariasis. Saeftel, M., Volkmann, L., Korten, S., Brattig, N., Al-Qaoud, K., Fleischer, B., Hoerauf, A. Microbes Infect. (2001) [Pubmed]
  17. Cardiac troponin T content in heart and skeletal muscle and in blood samples from ApoE/LDL receptor double knockout mice. Löwbeer, C., Forsberg, A.M., Tokuno, S., Hemdahl, A.L., Gustafsson, S.A., Valen, G. Clin. Chim. Acta (2004) [Pubmed]
  18. Efficacy of continuous cleansing with teicoplanin on post-CABG methicillin-resistant staphylococcus aureus (MRSA) mediastinitis: report of a case. Sezai, A., Shiono, M., Inoue, T., Hata, M., Iida, M., Niino, T., Saito, A., Hattori, T., Wakui, S., Soeda, M., Negishi, N., Sezai, Y. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. (2004) [Pubmed]
  19. Chest wall motion during spontaneous breathing and mechanical ventilation in dogs. Warner, D.O., Krayer, S., Rehder, K., Ritman, E.L. J. Appl. Physiol. (1989) [Pubmed]
  20. Effect of an intrathoracic injection of sodium hyaluronic acid on the prevention of pleural thickening in excess fluid of tuberculous thoracic cavity. Zhou, A., Guo, L., Tang, L. Clin. Exp. Pharmacol. Physiol. (2003) [Pubmed]
  21. Pleural phenol therapy for the treatment of chronic esophageal cancer pain. Lema, M.J., Myers, D.P., De Leon-Casasola, O., Penetrante, R. Regional anesthesia. (1992) [Pubmed]
  22. Palliative intracavitary carboplatin therapy in a cat with suspected pleural mesothelioma. Sparkes, A., Murphy, S., McConnell, F., Smith, K., Blunden, A.S., Papasouliotis, K., Vanthournout, D. J. Feline Med. Surg. (2005) [Pubmed]
  23. Multiple intracranial xanthogranulomas--case report. Nagatani, K., Waga, S., Takeuchi, J., Takebe, Y., Hohda, K., Hirano, A. Neurol. Med. Chir. (Tokyo) (1990) [Pubmed]
  24. Immunomodulation by treatment with Lactobacillus casei strain Shirota. Matsuzaki, T. Int. J. Food Microbiol. (1998) [Pubmed]
  25. Pulmonary hypoplasia in mice homozygous for the cartilage matrix deficiency (cmd) gene: a model for human congenital disorder. Houghton, M.J., Carey, J.C., Seegmiller, R.E. Pediatric pathology / affiliated with the International Paediatric Pathology Association. (1989) [Pubmed]
  26. Antitumor effect of intrapleural administration of Lactobacillus casei in mice. Matsuzaki, T., Yokokura, T., Mutai, M. Cancer Immunol. Immunother. (1988) [Pubmed]
  27. Quantification of thoracic volumes by three-dimensional imaging. Krayer, S., Rehder, K., Beck, K.C., Cameron, P.D., Didier, E.P., Hoffman, E.A. J. Appl. Physiol. (1987) [Pubmed]
  28. Phrenic nerve damage via a right thoracotomy in older children with secundum ASD. Helps, B.A., Ross-Russell, R.I., Dicks-Mireaux, C., Elliott, M.J. Ann. Thorac. Surg. (1993) [Pubmed]
  29. DNA typing as a strategy for resolving issues relevant to forensic toxicology. Chaturvedi, A.K., Vu, N.T., Ritter, R.M., Canfield, D.V. J. Forensic Sci. (1999) [Pubmed]
  30. Mediastinal tuberculous lymphadenitis diagnosed and treated by thoracoscopy. Suzuki, T., Suzuki, S., Kamio, Y., Hori, G., Endo, S., Suzuki, H. The Thoracic and cardiovascular surgeon. (1997) [Pubmed]
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