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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hospices

  • Six hospice inpatients with skin ulcers were given morphine sulfate 10 mg in Intrasite gel topically and morphine sulfate 10 mg subcutaneously over 4 hours, at least 48 hours apart, in randomized order [1].
  • CONTEXT: Many are calling for patients with advanced chronic obstructive pulmonary disease (COPD) to receive hospice care, but the traditional hospice model may be insufficient [2].
  • A retrospective analysis was undertaken of 67 patients with terminal head and neck cancer who were admitted to the Tel Hashomer Hospice between 1988 and 1992 [3].
  • Thus both clinical and immunological staging (AIDS or a CD4 count < 200 cells/ul) were associated with increased resource use in HIV infection and estimates of resource use for AIDS need to be increased by around one-third to take into account hospice use [4].
  • Clinical trial of a mucin-containing oral spray for treatment of xerostomia in hospice patients [5].

Psychiatry related information on Hospices


High impact information on Hospices

  • This is the first study the authors know of that examines the association between hospice enrollment length and subsequent major depressive disorder among surviving caregivers [9].
  • Philippe Pinel (1745-1826) served as "physician of the infirmaries" at Bicêtre, the public hospice for men near Paris, from 1793 to 1795 [10].
  • Of these, 40.9% died in an acute NHS hospital setting, 37.1% died at home, 10.4% died in hospices and 3.4% died in non-NHS hospitals [11].
  • The state Medicaid programs were surveyed by mail for this research in mid 1987 to determine if the states covered AZT (Retrovir), if limits apply to this coverage, if the states have or are developing AIDS-related policies, and if hospice care is a benefit [12].
  • Overall, acetaminophen (not in combination with other drugs) was used most frequently for nonhospice residents (25% of 1,673 prescriptions), whereas morphine derivatives were used most frequently for hospice residents (30% of 1,058 prescriptions) [13].

Biological context of Hospices

  • Utilizing combined costs per life year (based on hospital and hospice activity but not primary and community care) the ratio of costs for CD4 < 200 and CD4 > 200 was for most risk groups between 2-5:1 whilst for AIDS: pre-AIDS it was between 3.6-8.3:1 except for homosexuals where it was 12.6:1 [14].
  • Educational initiatives and certification programs for physicians (American Board of Hospice and Palliative Medicine) and nurses (National Board for Certification of Hospice and Palliative Nurses) have further delineated this area of practice as distinct from geriatrics, neurology, anesthesiology, or oncology [15].
  • The present randomized controlled study set in a hospice focused on the development of methodology for assessing patient comfort and quality of sleep and used this to compare two widely used, alternating air pressure mattresses (the Nimbus II and the Pegasus Airwave) [16].

Associations of Hospices with chemical compounds


Gene context of Hospices

  • It appears that the risk of symptomatic infection with MRSA in hospice patients is low, and the burden placed on this vulnerable group by conventional eradication regimes may be disproportionate to any benefit derived [22].
  • It was estimated that during the first three years of the hospice program, Medicare saved $1.26 for every dollar spent on Part A expenditures [23].
  • Is hospice referral ever appropriate in COPD [24]?
  • Questionnaires were sent to 346 hospice and palliative care services in Great Britain and Ireland. Replies were analysed by the Hospice Information Service. A total of 293 replies were received (84% response) [25].
  • Whilst the data from this study provide no evidence for increased benefit of a mucin-containing spray over a mucin-free placebo among xerostomic hospice patients, it is clear that both sprays provided worthwhile symptomatic relief of oral dryness for many of the participants [5].

Analytical, diagnostic and therapeutic context of Hospices


  1. The bioavailability of morphine applied topically to cutaneous ulcers. Ribeiro, M.D., Joel, S.P., Zeppetella, G. Journal of pain and symptom management. (2004) [Pubmed]
  2. Dying with lung cancer or chronic obstructive pulmonary disease: insights from SUPPORT. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Claessens, M.T., Lynn, J., Zhong, Z., Desbiens, N.A., Phillips, R.S., Wu, A.W., Harrell, F.E., Connors, A.F. Journal of the American Geriatrics Society. (2000) [Pubmed]
  3. Care of the terminal head and neck cancer patient in the hospice setting. Talmi, Y.P., Roth, Y., Waller, A., Chesnin, V., Adunski, A., Lander, M.I., Kronenberg, J. Laryngoscope (1995) [Pubmed]
  4. Hospital and hospice resource use of HIV-positive patients in Edinburgh. Brettle, R.P., Atkinson, F.I., Wilcock, J., Richardson, A., Lewis, R., MacCullum, L., Bath, G. International journal of STD & AIDS. (1997) [Pubmed]
  5. Clinical trial of a mucin-containing oral spray for treatment of xerostomia in hospice patients. Sweeney, M.P., Bagg, J., Baxter, W.P., Aitchison, T.C. Palliative medicine. (1997) [Pubmed]
  6. Development of advanced practice nurses in South Korea. Kang, Y. Applied nursing research : ANR. (2005) [Pubmed]
  7. Criteria for enrolling dementia patients in hospice: a replication. Hanrahan, P., Raymond, M., McGowan, E., Luchins, D.J. The American journal of hospice & palliative care. (1999) [Pubmed]
  8. Terminal care: evaluation of in-patient service at St Christopher's Hospice. Part II. Self assessments of effects of the service on surviving spouses. Parkes, C.M. Postgraduate medical journal. (1979) [Pubmed]
  9. Depression among surviving caregivers: does length of hospice enrollment matter? Bradley, E.H., Prigerson, H., Carlson, M.D., Cherlin, E., Johnson-Hurzeler, R., Kasl, S.V. The American journal of psychiatry. (2004) [Pubmed]
  10. Philippe Pinel's "Memoir on Madness" of December 11, 1794: a fundamental text of modern psychiatry. Weiner, D.B. The American journal of psychiatry. (1992) [Pubmed]
  11. Why are a quarter of all cancer deaths in south-east England registered by death certificate only? Factors related to death certificate only registrations in the Thames Cancer Registry between 1987 and 1989. Pollock, A.M., Vickers, N. Br. J. Cancer (1995) [Pubmed]
  12. State Medicaid coverage of AZT and AIDS-related policies. Buchanan, R.J. American journal of public health. (1988) [Pubmed]
  13. Does receipt of hospice care in nursing homes improve the management of pain at the end of life? Miller, S.C., Mor, V., Wu, N., Gozalo, P., Lapane, K. Journal of the American Geriatrics Society. (2002) [Pubmed]
  14. The cost of health care for HIV-positive patients. Brettle, R.P., Atkinson, F.I., Wilcock, J., Richardson, A., Lewis, R., MacCallum, L., Bath, G. International journal of STD & AIDS. (1997) [Pubmed]
  15. End-of-life care education in United States pharmacy schools. Herndon, C.M., Jackson, K., Fike, D.S., Woods, T. The American journal of hospice & palliative care. (2003) [Pubmed]
  16. Alternating pressure mattresses: comfort and quality of sleep. Grindley, A., Acres, J. British journal of nursing (Mark Allen Publishing) (1996) [Pubmed]
  17. Differences in physician access patterns to hospice care. Stillman, M.J., Syrjala, K.L. Journal of pain and symptom management. (1999) [Pubmed]
  18. A comparison of subcutaneous morphine and fentanyl in hospice cancer patients. Hunt, R., Fazekas, B., Thorne, D., Brooksbank, M. Journal of pain and symptom management. (1999) [Pubmed]
  19. Care of cancer patients in a home-based hospice program: a comparison of oncologists and primary care physicians. Ramsay, A. The Journal of family practice. (1992) [Pubmed]
  20. Methylphenidate in terminal depression. Macleod, A.D. Journal of pain and symptom management. (1998) [Pubmed]
  21. Lactulose vs sorbitol for treatment of obstipation in hospice programs. Weed, H.G. Mayo Clin. Proc. (2000) [Pubmed]
  22. An investigation of MRSA infection in a hospice. Ali, S., Sykes, N., Flock, P., Hall, E., Buchan, J. Palliative medicine. (2005) [Pubmed]
  23. The effects of hospice coverage on Medicare expenditures. Kidder, D. Health services research. (1992) [Pubmed]
  24. Is hospice referral ever appropriate in COPD? Yeager, H. Chest (1997) [Pubmed]
  25. Palliative care services in Britain and Ireland--update 1991. Eve, A., Smith, A.M. Palliative medicine. (1994) [Pubmed]
  26. Board certification in palliative care for U.S. physicians. Officers and Trustees of the American Board of Hospice and Palliative Medicine. Holman, G.H., Smith, D.C. Journal of pain and symptom management. (1999) [Pubmed]
  27. Breakthrough strong opioid analgesia prescription in patients using transdermal fentanyl admitted to a hospice. Lawrie, I., Lloyd-Williams, M., Waterhouse, E. The American journal of hospice & palliative care. (2003) [Pubmed]
  28. Terminal care: evaluation of in-patient service at St Christopher's Hospice. Part I. Views of surviving spouse on effects of the service on the patient. Parkes, C.M. Postgraduate medical journal. (1979) [Pubmed]
  29. CPT coding for hospice in long-term care. Crossno, R.J. Journal of the American Medical Directors Association. (2004) [Pubmed]
  30. Factors associated with length of stay in a mid-sized, urban hospice. Somova, M.J., Somov, P.G., Lawrence, J.C., Frantz, T.T. The American journal of hospice & palliative care. (2000) [Pubmed]
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