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MeSH Review

Skin Ulcer

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Disease relevance of Skin Ulcer


Psychiatry related information on Skin Ulcer


High impact information on Skin Ulcer

  • Tretinoin tocoferil is an alpha-tocopherol ester of all-trans retinoic acid (RA) and safely used in the treatment of skin ulcer [7].
  • Chemotherapeutic agents such as doxorubicin, which bind to DNA, are especially prone to cause severe extravasation skin ulcers [8].
  • These results show that experimental MMC-induced skin ulcers in mice can be ameliorated with an immediate application of topical DMSO [9].
  • Biopsy samples of re-epithelizing epidermis from patients with skin ulcers were collected, and HBD3 mRNA level measured in the epidermis [10].
  • CR also extended life span in p53(+/-) mice, but 50% of p53(+/-) mice subjected to CR still developed skin ulcers and mean life span was shorter than that seen in WT mice [11].

Chemical compound and disease context of Skin Ulcer

  • Ultrastructure of doxorubicin (adriamycin)-induced skin ulcers in rats [12].
  • All of the patients had a history of both intravenous and subcutaneous cocaine and heroin use with chronic suppurative skin ulcers [13].
  • Assessment of skin ulcer healing capability by technetium-99m phosphate angiogram and blood-pool images [14].
  • These findings give experimental support for the clinical use of CO2 bathing in the treatment of disturbances of skin circulation as well as skin ulcers and wounds [15].
  • It also produced skin ulcers on id administration, but they were less severe than those caused by bisantrene [16].

Biological context of Skin Ulcer

  • The skin ulcers continued to deteriorate despite a swift reduction of the IL-5 gene expression and peripheral eosinophil count following systemic corticosteroid treatment [17].
  • These results suggest that SM-10902 ointment promotes wound healing through the stimulation of angiogenesis and the improvement of blood flow in neovascularization of repairing wound and may be useful in the treatment of skin ulcers caused by peripheral circulatory insufficiency [18].

Anatomical context of Skin Ulcer

  • Age younger than 40 years, no skin ulcers, no tumor invasion in the superficial dermis, and CD8+, TcRbetaF1 +, CD95 (Fas)-, and CD56- tumor cells were significantly better prognostic factors (P < .01) [19].
  • The proportion of methicillin resistance was highest among S. aureus isolates associated with upper respiratory specimens (42.8%); the proportion of methicillin resistance was 39.3% among skin ulcer isolates, 10.7% among urinary tract infection isolates, and lowest among isolates associated with blood and prostate discharge (3.6% each) [20].
  • The aim of this study was to examine immunohistochemically the expression of beta-defensin-2 (hBD2), GM-CSF, VEGF growth factors and accumulation of CD1a+ Langerhans cells (LC) in epidermis from chronic skin ulcers and to compare it to normal skin from the corresponding areas [21].

Gene context of Skin Ulcer

  • We examined these proteins by immunohistochemical methods in 12 cases of skin ulcer, using seven anti-keratin antibodies, anti-filaggrin, and anti-p63 antibody [22].
  • Although keratinocyte-specific Stat3-disrupted mice were born normal with intact skin and the first hair cycle, they exhibited retardation of wound healing and absence of the second hair cycle onward, leading to development of spontaneous skin ulcers and alopecia as they aged [23].
  • Expression of telomerase reverse transcriptase in radiation-induced chronic human skin ulcer [24].
  • Overexpression of MDM2, p53, and NCAM proteins in human radiation-induced skin ulcers [25].
  • It has been hypothesized that excessive activity of matrix metalloproteinases (MMPs), in particular the gelatinases MMP-9 and MMP-2, contributes to poor healing of chronic skin ulcers [26].

Analytical, diagnostic and therapeutic context of Skin Ulcer


  1. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Metcalf, D., Mifsud, S., Di Rago, L., Nicola, N.A., Hilton, D.J., Alexander, W.S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Xia, Y.P., Li, B., Hylton, D., Detmar, M., Yancopoulos, G.D., Rudge, J.S. Blood (2003) [Pubmed]
  3. Amantadine-induced peripheral neuropathy. Shulman, L.M., Minagar, A., Sharma, K., Weiner, W.J. Neurology (1999) [Pubmed]
  4. The angiogenic peptide vascular endothelial growth factor (VEGF) is expressed in chronic sacral pressure ulcers. Pufe, T., Paulsen, F., Petersen, W., Mentlein, R., Tsokos, M. J. Pathol. (2003) [Pubmed]
  5. Attenuation and immunogenicity in primates of vaccinia virus recombinants expressing human interleukin-2. Flexner, C., Moss, B., London, W.T., Murphy, B.R. Vaccine (1990) [Pubmed]
  6. Four novel PEPD alleles causing prolidase deficiency. Ledoux, P., Scriver, C., Hechtman, P. Am. J. Hum. Genet. (1994) [Pubmed]
  7. Enhancement of activity of 1alpha, 25-dihydroxyvitamin D3 for growth inhibition and differentiation induction of human myelomonocytic leukemia cells by tretinoin tocoferil, an alpha-tocopherol ester of all-trans retinoic acid. Makishima, M., Kanatani, Y., Yamamoto-Yamaguchi, Y., Honma, Y. Blood (1996) [Pubmed]
  8. Etiology and treatment of chemotherapeutic agent extravasation injuries: a review. Rudolph, R., Larson, D.L. J. Clin. Oncol. (1987) [Pubmed]
  9. Mitomycin C skin toxicity studies in mice: reduced ulceration and altered pharmacokinetics with topical dimethyl sulfoxide. Dorr, R.T., Soble, M.J., Liddil, J.D., Keller, J.H. J. Clin. Oncol. (1986) [Pubmed]
  10. Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection. Sawamura, D., Goto, M., Shibaki, A., Akiyama, M., McMillan, J.R., Abiko, Y., Shimizu, H. Gene Ther. (2005) [Pubmed]
  11. Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice. Perkins, S.N., Hursting, S.D., Phang, J.M., Haines, D.C. J. Invest. Dermatol. (1998) [Pubmed]
  12. Ultrastructure of doxorubicin (adriamycin)-induced skin ulcers in rats. Rudolph, R., Woodward, M., Hurn, I. Cancer Res. (1979) [Pubmed]
  13. Hepatic amyloidosis in intravenous drug abusers and AIDS patients. Osick, L.A., Lee, T.P., Pedemonte, M.B., Jacob, L., Chauhan, P., Navarro, C., Comer, G.M. J. Hepatol. (1993) [Pubmed]
  14. Assessment of skin ulcer healing capability by technetium-99m phosphate angiogram and blood-pool images. Alazraki, N., Dries, D., Lawrence, P., Morton, K., Datz, F., Taylor, A. J. Nucl. Med. (1985) [Pubmed]
  15. Topical application of CO2 increases skin blood flow. Ito, T., Moore, J.I., Koss, M.C. J. Invest. Dermatol. (1989) [Pubmed]
  16. New antitumor agents containing the anthracene nucleus. Wunz, T.P., Dorr, R.T., Alberts, D.S., Tunget, C.L., Einspahr, J., Milton, S., Remers, W.A. J. Med. Chem. (1987) [Pubmed]
  17. The interleukin-5 messenger RNA expression in a patient with idiopathic hypereosinophilic syndrome. Ho, K.K., Ho, A.S., Leung, R.C., Lai, C.K., Lai, K.N. Clin. Exp. Allergy (1998) [Pubmed]
  18. Effect of topical application of a stable prostacyclin analogue, SM-10902 on wound healing in diabetic mice. Yamamoto, T., Horikawa, N., Komuro, Y., Hara, Y. Eur. J. Pharmacol. (1996) [Pubmed]
  19. Clinicopathologic analysis of 22 cases of subcutaneous panniculitis-like CD56- or CD56+ lymphoma and review of 44 other reported cases. Takeshita, M., Imayama, S., Oshiro, Y., Kurihara, K., Okamoto, S., Matsuki, Y., Nakashima, Y., Okamura, T., Shiratsuchi, M., Hayashi, T., Kikuchi, M. Am. J. Clin. Pathol. (2004) [Pubmed]
  20. Nosocomial infection caused by methicillin-resistant Staphylococcus aureus in Palestine. Adwan, K., Abu-Hasan, N., Adwan, G., Jarrar, N., Abu-Shanab, B., Abu-Zant, A. Microb. Drug Resist. (2005) [Pubmed]
  21. Expression of natural antimicrobial peptide beta-defensin-2 and Langerhans cell accumulation in epidermis from human non-healing leg ulcers. Galkowska, H., Olszewski, W.L., Wojewodzka, U. Folia Histochem. Cytobiol. (2005) [Pubmed]
  22. Cytokeratin, filaggrin, and p63 expression in reepithelialization during human cutaneous wound healing. Kurokawa, I., Mizutani, H., Kusumoto, K., Nishijima, S., Tsujita-Kyutoku, M., Shikata, N., Tsubura, A. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2006) [Pubmed]
  23. Tissue regeneration: hair follicle as a model. Sano, S., Takeda, J., Yoshikawa, K., Itami, S. J. Investig. Dermatol. Symp. Proc. (2001) [Pubmed]
  24. Expression of telomerase reverse transcriptase in radiation-induced chronic human skin ulcer. Zhao, P., Zhijun, L., Yali, L., Zhong, M., Gu, Q., Wang, D. J. Environ. Pathol. Toxicol. Oncol. (2002) [Pubmed]
  25. Overexpression of MDM2, p53, and NCAM proteins in human radiation-induced skin ulcers. Zhao, P., Wang, D., Gao, Y., Yang, Z., Li, X. J. Environ. Pathol. Toxicol. Oncol. (1998) [Pubmed]
  26. Ectopic localization of matrix metalloproteinase-9 in chronic cutaneous wounds. Mirastschijski, U., Impola, U., Jahkola, T., Karlsmark, T., AGren, M.S., Saarialho-Kere, U. Hum. Pathol. (2002) [Pubmed]
  27. Dose-dependent skin ulcers in mice treated with DNA binding antitumor antibiotics. Soble, M.J., Dorr, R.T., Plezia, P., Breckenridge, S. Cancer Chemother. Pharmacol. (1987) [Pubmed]
  28. Prolidase deficiency: a multisystemic hereditary disorder. Bissonnette, R., Friedmann, D., Giroux, J.M., Dolenga, M., Hechtman, P., Der Kaloustian, V.M., Dubuc, R. J. Am. Acad. Dermatol. (1993) [Pubmed]
  29. Effect of beraprost sodium (TRK-100) on acetic acid-induced skin ulcer. Nishio, S., Yamaguchi, M., Yamada, N., Uenishi, N., Kageyama, Y., Umetsu, T. Res. Commun. Chem. Pathol. Pharmacol. (1989) [Pubmed]
  30. New strategies to identify patients harbouring antibiotic-resistant bacteria at hospital admission. Tacconelli, E. Clin. Microbiol. Infect. (2006) [Pubmed]
  31. Overexpression of c-erbB-2 and p21 oncoproteins in human radiation-induced skin ulcers. Zhao, P., Yang, Z., Wang, D.W., Gao, Y., Li, X., Li, G. J. Environ. Pathol. Toxicol. Oncol. (1995) [Pubmed]
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