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MeSH Review


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Disease relevance of Somatostatinoma


High impact information on Somatostatinoma


Chemical compound and disease context of Somatostatinoma


Biological context of Somatostatinoma


Anatomical context of Somatostatinoma


Gene context of Somatostatinoma

  • In somatostatinoma, a rare malignant somatostatin (SST)-secreting neoplasia, tumour regression is rarely observed, implying the need for novel antiproliferative strategies [20].
  • Pancreatic insulinomas had an heterogeneous SSTR expression, while 100% of somatostatinomas expressed SSTR5 and 100% gastrinomas and glucagonomas expressed SSTR2 [21].
  • One intestinal somatostatinoma contained gastrin cells as a minority cell population [22].
  • All of the tumors showed immunocytochemical evidence of somatostatinomas, and only one VRNF-associated tumor showed immunoreactivity for an additional regulatory substance, as opposed to three of those not associated with VRNF [2].
  • Twenty pancreatic endocrine tumors and one duodenal somatostatinoma were stained with polyclonal antisera against eight hormones, neuron-specific (NSE), and with a monoclonal antibody against the endocrine granule protein chromogranin [23].

Analytical, diagnostic and therapeutic context of Somatostatinoma


  1. Characterization of somatostatin-like components in the tumors and plasma of a patient with a somatostatinoma. Conlon, J.M., McCarthy, D., Krejs, G., Unger, R.H. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  2. Duodenal carcinoids in patients with and without neurofibromatosis. A comparative study. Dayal, Y., Tallberg, K.A., Nunnemacher, G., DeLellis, R.A., Wolfe, H.J. Am. J. Surg. Pathol. (1986) [Pubmed]
  3. Epidemiology, clinical features and diagnosis of gastroenteropancreatic endocrine tumours. Tomassetti, P., Migliori, M., Lalli, S., Campana, D., Tomassetti, V., Corinaldesi, R. Ann. Oncol. (2001) [Pubmed]
  4. Glucose turnover and gluconeogenesis in a patient with somatostatinoma. Lowry, S.F., Burt, M.E., Brennan, M.F. Surgery (1981) [Pubmed]
  5. Prevalence, characteristics and prognosis of MEN 1-associated glucagonomas, VIPomas, and somatostatinomas: study from the GTE (Groupe des Tumeurs Endocrines) registry. Lévy-Bohbot, N., Merle, C., Goudet, P., Delemer, B., Calender, A., Jolly, D., Thiéfin, G., Cadiot, G. Gastroenterol. Clin. Biol. (2004) [Pubmed]
  6. Comparative diagnostic value of the calcium-pentagastrin test versus the tolbutamide test in a patient with a somatostatinoma. Budmiger, H., Bühler, H., Häcki, W., Stamm, B., Streuli, R., Ammann, R. Gastroenterology (1987) [Pubmed]
  7. A case of duodenal somatostatinoma: diagnostic usefulness of calcium--pentagastrin test. Somers, G., Pipeleers-Marichal, M., Gepts, W., Pipeleers, D. Gastroenterology (1983) [Pubmed]
  8. NIH conference. Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut. Gorden, P., Comi, R.J., Maton, P.N., Go, V.L. Ann. Intern. Med. (1989) [Pubmed]
  9. Onset of rheumatoid arthritis following curative treatment of a somatostatinoma. Grasland, A., Pouchot, J., Vinceneux, P., Ruszniewski, P. Arthritis Rheum. (2002) [Pubmed]
  10. Use of the somatostatin analogue octreotide to localise and manage somatostatin-producing tumours. Angeletti, S., Corleto, V.D., Schillaci, O., Marignani, M., Annibale, B., Moretti, A., Silecchia, G., Scopinaro, F., Basso, N., Bordi, C., Delle Fave, G. Gut (1998) [Pubmed]
  11. The effects of sodium valproate on plasma somatostatin and insulin in humans. Kusunoki, M., Yamamura, T., Ichii, S., Fujita, S., Nakai, T., Utsunomiya, J. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  12. Pancreatic somatostatinoma: abundance of somatostatin-28(1-12)-like immunoreactivity in tumor and plasma. Patel, Y.C., Ganda, O.P., Benoit, R. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  13. Case report: somatostatin producing teratoma, causing rapidly alternating extreme hyperglycemia and hypoglycemia, and ovarian somatostatinoma. Gregersen, G., Holst, J.J., Trankjaer, A., Stadil, F., Mogensen, A.M. Metab. Clin. Exp. (2002) [Pubmed]
  14. Use of calcium provocative test in the diagnosis of gastroenteropancreatic endocrine tumors. Vezzadini, C., Poggioli, R., Casoni, I., Vezzadini, P. Panminerva medica. (1996) [Pubmed]
  15. Somatostatin receptor scintigraphy of malignant somatostatinoma with indium-111-pentetreotide. Schillaci, O., Annibale, B., Scopinaro, F., delle Fave, G., Colella, A.C. J. Nucl. Med. (1997) [Pubmed]
  16. Neuropeptide Y and neuropeptide Y 3-36: isolation from human pancreatic endocrine tumours. Shaw, C., Cormican, K., Thim, L., Maule, A.G., Sloan, J.M., Buchanan, K.D. Regul. Pept. (1993) [Pubmed]
  17. Somatostatin-secreting islet cell tumor (somatostatinoma): suppression of growth hormone (GH) release induced by GH-releasing hormone. Iguchi, H., Kumagai, S., Seo, I.H., Wakasugi, H., Hara, Y., Abe, M. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  18. von Recklinghausen's disease associated with somatostatin-rich duodenal carcinoid (somatostatinoma), medullary thyroid carcinoma and diffuse adrenal medullary hyperplasia. Yoshida, A., Hatanaka, S., Ohi, Y., Umekita, Y., Yoshida, H. Acta Pathol. Jpn. (1991) [Pubmed]
  19. Carcinoid syndrome due to a malignant somatostatinoma. Ozbakir, O., Keleştimur, F., Oztürk, F., Sözüer, E., Unal, A., Patiroğlu, T.E., Güven, K. Postgraduate medical journal. (1995) [Pubmed]
  20. Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma. Galli, G., Zonefrati, R., Gozzini, A., Mavilia, C., Martineti, V., Tognarini, I., Nesi, G., Marcucci, T., Tonelli, F., Tommasi, M., Raggi, C.C., Pinzani, P., Brandi, M.L. Endocr. Relat. Cancer (2006) [Pubmed]
  21. Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis. Papotti, M., Bongiovanni, M., Volante, M., Allìa, E., Landolfi, S., Helboe, L., Schindler, M., Cole, S.L., Bussolati, G. Virchows Arch. (2002) [Pubmed]
  22. Majority and minority cell populations in GEP and bronchial endocrine tumours. Sundler, F., Alumets, J., Håkanson, R. Scand. J. Gastroenterol. Suppl. (1979) [Pubmed]
  23. Immunohistochemical detection of chromogranin and neuron-specific enolase in pancreatic endocrine neoplasms. Lloyd, R.V., Mervak, T., Schmidt, K., Warner, T.F., Wilson, B.S. Am. J. Surg. Pathol. (1984) [Pubmed]
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